A5015099972- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Advanced Queuing Theory Analysis
- Immune cells in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Autophagy in Disease and Therapy
- Probability and Risk Models
- Hemodynamic Monitoring and Therapy
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Calcium signaling and nucleotide metabolism
- Erythrocyte Function and Pathophysiology
- Adenosine and Purinergic Signaling
- Berry genetics and cultivation research
- Hemoglobin structure and function
- Mitochondrial Function and Pathology
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Central Hospital of Zibo
2025
Hunan Provincial Center for Disease Control and Prevention
2022-2024
Xiangtan University
2016-2024
China International Science and Technology Cooperation
2024
Henan Provincial People's Hospital
2022-2024
Anyang Hospital of Traditional Chinese Medicine
2024
Zhengzhou University
2016-2024
Zhejiang Chinese Medical University
2024
Abstract Rechargeable aqueous zinc (Zn) ion‐based energy storage systems have been reviving recently because of their low cost and high safety merits; however, they still suffer from the problems corrosion dendrite growth on Zn metal anodes that cause gas generation early battery failure. Unfortunately, problem has not received sufficient attention until now. Here, it is pioneeringly demonstrated decorating surface with a dual‐functional metallic indium (In) layer, acting as both inhibitor...
Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, atherosclerosis, addition to its recognized role metabolic syndrome diabetes. Numerous studies have presented contradictory findings about the of HO-1 diabetic cardiomyopathy (DCM). In this study, we explored myocardial myofibril structure, using a streptozotocin (STZ)-induced diabetes model mice systemically overexpressing (Tg-HO-1) or...
Abstract Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on immune function sepsis, an expert consensus focusing monitoring treatment sepsis-induced was developed. Literature related to sepsis were retrieved from PubMed, Web Science, Chinese National Knowledge Infrastructure design items opinions collected through online questionnaire. Then, Delphi method used form opinions, RAND...
Osteosarcoma is the most common primary bone cancer with a high propensity for local invasion and metastasis. An increasing number of research studies show that telomeres play an important role in occurrence development cancer. Thus, we established telomere-related signature osteosarcoma to comprehensively evaluate pathogenic roles this disease. The data on were collected from TARGET Gene Expression Omnibus databases. First, constructed using univariate LASSO Cox regression analyses....
Background: Sepsis and sepsis-associated encephalopathy (SAE) are common intensive care unit (ICU) diseases; the morbidity mortality high. The present study analyzed sensitivity of different diagnostic criteria sepsis 1.0 3.0, epidemiological characteristics SAE, explored its risk factors for death, short-term, long-term prognosis. Methods: retrospective included patients in ICU from January 2015 to June 2016. After excluding 58 patients, 175 were assigned either an SAE or a non-SAE group...
Intracellular tau aggregates composed of neurofibrillary tangles (NFTs) are a defining feature Alzheimer's disease (AD). Increased expression heme oxygenase-1 (HO-1) is common phenomenon in AD. Interestingly, the spatial distribution HO-1 essentially identical to that pathological accumulation In this study, we developed new transgenic mouse overexpressing HO-1, called CAG-HO-1 Tg mice, explore relationship between and aggregation. model, found long-term overexpression significantly promoted...
The pathogenesis of sepsis is complex. Mitochondrial dysfunction, which responsible for energy metabolism, intrinsic apoptotic pathway, oxidative stress, and systemic inflammatory responses, closely related with severe induced death. Mitochondria DNA (mtDNA) contain un-methylated cytosine phosphate guanine (CpG) motifs, exhibit immune stimulatory capacities. aim this study was to investigate the role mechanism mtDNA release on lipopolysaccharide (LPS) acute lung injury (ALI) inflammation....
The aim of the present study was to investigate whether methylation angiotensin I converting enzyme 2 (ACE2) promoter increases risk essential hypertension (EH). A total 96 patients with EH were recruited and sex‑ age‑matched healthy controls. Methylation 5 CpG dinucleotides in ACE2 quantified using bisulfite pyrosequencing. Logistic regression multiple linear used adjust for confounding factors generalized multifactor dimensionality reduction (GMDR) method applied high‑order interactions....
We investigated the role of dynamic changes serum levels S100B protein in brain injury and poor outcome sepsis. This is a prospective cohort study designed to include 104 adult patients with sepsis who are admitted ICU from Jan 2015 Aug 2016. Sepsis was defined as 3.0. Patients GCS score <15, or at least one positive CAM-ICU were thought have dysfunction. 59 diagnosed SAE rest 45 non-SAE. Serum measured on day 1 3 after admission. Primary outcomes included dysfunction 28-day/180-day...
Background: Since the coronavirus disease-2019 (COVID-19) outbreak, intensive care unit (ICU) healthcare workers were responsible for critical infected patients. However, few studies focused on mental health of ICU workers. This study aimed to investigate psychological impact COVID-19 in China. Methods: We distributed nine-item Patient Health Questionnaire (PHQ-9) and seven-item General Anxiety Disorder questionnaire (GAD-7) online Respondents divided into frontline second-line according...
Hypoxic-ischemic encephalopathy (HIE) is a severe anoxic brain injury that leads to premature mortality or long-term disabilities in infants. Neuroinflammation vital contributor the pathogenic cascade post-HIE and mediator secondary neuronal death. As plasma membrane G-protein-coupled receptor, GPR39, exhibits anti-inflammatory activity several diseases. This study aimed explore neuroprotective function of GPR39 through inhibition inflammation post-hypoxic-ischemic (HI) elaborate...
Abstract Background Patients with sepsis‐associated encephalopathy (SAE) often exhibit cognitive impairments. Despite this, the underlying mechanisms of SAE remain largely unexplored. Here, we explored role serotonergic neurotransmission in dysfunction two mouse models SAE. Methods The were established by injection lipopolysaccharide (LPS, 10 mg/kg, intraperitoneal) and cecal ligation puncture (CLP) respectively. Barnes maze, new object recognition test open field used to evaluate effects...
Bioimaging is a key technique for monitoring behavior and activity in vivo plays an important role the life science medical fields. In present work, first time, new, safe cellulose based hybrid hydrogel was constructed from solution containing rare-earth doped phosphor (PP) alkali/urea aqueous system using epichlorohydrin as crosslinker. Its structure properties were characterized by wide angle X-ray diffraction, FT-IR spectra, solid-state 13C NMR, field emission scanning electron...