A5053317931- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cholinesterase and Neurodegenerative Diseases
- Winter Sports Injuries and Performance
- Advanced Decision-Making Techniques
- Intensive Care Unit Cognitive Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Retinal Imaging and Analysis
- Liver Disease Diagnosis and Treatment
- Microgrid Control and Optimization
- Particle accelerators and beam dynamics
- Advanced Glycation End Products research
- Medicinal Plants and Neuroprotection
- Smart Grid and Power Systems
- Educational Technology and Pedagogy
- Insect-Plant Interactions and Control
- Pharmacological Effects and Toxicity Studies
University of Science and Technology of China
2022-2025
Zhengzhou University
2025
Sichuan University
2005-2025
Xuzhou Medical College
2020-2025
South China Agricultural University
2025
Guiyang Medical University
2025
Hangzhou Dianzi University
2024
Nanjing Agricultural University
2022-2024
Southwest Petroleum University
2024
Loma Linda University
2021-2023
The secondary injury caused by traumatic brain (TBI), especially white matter (WMI), is highly sensitive to neuroinflammation, which further leads unfavored long-term outcomes. Although the cross-talk between three active events, immune cell infiltration, BBB breakdown, and proinflammatory microglial/macrophage polarization, plays a role in vicious cycle, its mechanisms are not fully understood. It has been reported that cordycepin, an extract from Cordyceps militaris, can inhibit...
Population aging and smoking are both major challenges worldwide, particularly in developing countries. We preliminarily explored the relationship of cessation duration cognitive function among middle-aged older Chinese. The data comes from China Health Retirement Longitudinal Study (CHARLS) wave 4. Smoking information was collected by standardized questionnaire. Global memory-specific functions were assessed. used restricted cubic spline to explore curvilinear relationship. After...
Background . Albumin has been regarded as a potent antioxidant with free radical scavenging activities. Oxidative stress and neuronal apoptosis are responsible for its highly damaging effects on brain injury after intracerebral hemorrhage (ICH). Here, the present study investigated neuroprotective effect of albumin against early ICH potential underlying mechanisms. Methods Adult male Sprague‐Dawley rats were subjected to intrastriatal injection autologous blood induce ICH. Human serum was...
Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated with high mortality and morbidity. Neuroinflammation an important factor leading to ICH-induced neurological injuries. C-C Chemokine Receptor 4 (CCR4) plays role in enhancing hematoma clearance after ICH. However, it unclear whether CCR4 activation can ameliorate neuroinflammation apoptosis neurons following The aim the present study was examine effects recombinant CCL17 (rCCL17)-dependent on neuronal...
Serine-arginine protein kinases 2 (SRPK2) is a cell cycle-regulated kinase that phosphorylates serine/arginine domain-containing proteins and mediates pre-mRNA splicing with unclear function in neurons. Here, we show SRPK2 tau on S214, suppresses tau-dependent microtubule polymerization, inhibits axonal elongation Depletion of dentate gyrus phosphorylation APP/PS1 mouse alleviates the impaired cognitive behaviors. The defective LTP mice also improved after depletion. Moreover, active...
Hypoxic-ischemic encephalopathy (HIE) is a severe anoxic brain injury that leads to premature mortality or long-term disabilities in infants. Neuroinflammation vital contributor the pathogenic cascade post-HIE and mediator secondary neuronal death. As plasma membrane G-protein-coupled receptor, GPR39, exhibits anti-inflammatory activity several diseases. This study aimed explore neuroprotective function of GPR39 through inhibition inflammation post-hypoxic-ischemic (HI) elaborate...
Abstract Background Alzheimer’s disease (AD) is pathologically characterized by excessive accumulation of amyloid-beta (Aβ) fibrils within the brain and activation astrocytes microglial cells. In this study, we examined anti-inflammatory anti-amyloidogenic effects 2,4-bis(p-hydroxyphenyl)-2-butenal (HPB242), an compound produced tyrosine-fructose Maillard reaction. Methods 12-month-old Tg2576 mice were treated with HPB242 (5 mg/kg) for 1 month then cognitive function was assessed Morris...
When attacked by herbivores, plants release herbivore-induced plant volatiles (HIPV) that may function in direct defence repelling herbivores or reducing their growth. Emission of HIPV also contribute to indirect attracting natural enemies the herbivore. Here, cabbage (Brassica oleracea L.) (receiver plants) previously exposed and subsequently induced through feeding five Pieris brassicae L. caterpillars attracted more Cotesia glomerata parasitoids than control plants. HIPVs which receiver...
Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases. Herein, we investigated the role NK1R using Aprepitant to attenuate NLRC4-dependent neuronal pyroptosis after intracerebral hemorrhage (ICH), as well underlying mechanism.A total 182 CD-1 mice were used. ICH was induced injection autologous blood into right basal ganglia. Aprepitant, selective...
Our previous studies demonstrated that CCL17 and its receptor CCR4 play crucial roles in neuroinflammation microglial activation following intracerebral hemorrhage (ICH). However, the specific mechanisms by which CCL17/CCR4 axis regulates polarization hematoma clearance remain unclear. This study investigates how signaling pathway modulates phenotype transition enhances resolution after ICH, building upon our earlier findings showing CCR4's involvement neuroinflammatory responses. Using...
Acute kidney injury (AKI) is a common critical clinical disease with high morbidity and mortality rates. Ischemia-reperfusion (IR) the main cause of AKI, there no effective treatment or prevention. Therefore, it to screen for therapeutic agents find targets. DKS26 derivative oleanolic acid (OA) optimized bioavailability while retaining anti-inflammatory, antioxidant, anti-apoptotic properties OA. This study aimed investigate effects on AKI its underlying molecular mechanisms. We established...