A5042283138- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Histone Deacetylase Inhibitors Research
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Neurological Disorders and Treatments
- Heat shock proteins research
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autophagy in Disease and Therapy
- Traumatic Brain Injury Research
- Nanoparticles: synthesis and applications
- Freezing and Crystallization Processes
- Phagocytosis and Immune Regulation
- Refrigeration and Air Conditioning Technologies
- Advanced Glycation End Products research
- Intracerebral and Subarachnoid Hemorrhage Research
- MXene and MAX Phase Materials
- Apelin-related biomedical research
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
State Key Laboratory of Medical Neurobiology
2020-2025
Brigham and Women's Hospital
2024-2025
Eye & ENT Hospital of Fudan University
2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Zhejiang A & F University
2025
State Forestry and Grassland Administration
2025
Huashan Hospital
2020-2024
Fudan University
2020-2024
Beijing Institute of Fashion Technology
2024
The secondary injury caused by traumatic brain (TBI), especially white matter (WMI), is highly sensitive to neuroinflammation, which further leads unfavored long-term outcomes. Although the cross-talk between three active events, immune cell infiltration, BBB breakdown, and proinflammatory microglial/macrophage polarization, plays a role in vicious cycle, its mechanisms are not fully understood. It has been reported that cordycepin, an extract from Cordyceps militaris, can inhibit...
The accumulation of self-renewed polarized microglia in the penumbra is a critical neuroinflammatory process after ischemic stroke, leading to secondary demyelination and neuronal loss. Although known regulate tumor cell proliferation neuroinflammation, HDAC3's role microgliosis microglial polarization remains unclear. We demonstrated that HDAC3 knockout (HDAC3-miKO) ameliorated poststroke long-term functional histological outcomes. RNA-seq analysis revealed mitosis as primary affected...
Microglia play essential roles in neuroinflammatory responses after traumatic brain injury (TBI). Our previous studies showed that phenotypes of microglia, as well infiltrating macrophages, altered at different stages CNS injury, which was correlated to functional outcomes. IL-13 is an anti-inflammatory cytokine has been reported protect against demyelination and spinal cord through immunomodulation. The effects microglia/macrophage-mediated immune TBI remain unknown. In this study, we...
Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- anti-inflammatory properties. Interleukin-13 (IL-13) is an cytokine that regulates polarization toward phenotype. However, it not clear whether IL-13 beneficial long-term the underlying molecular mechanism(s) remain unknown. Thus, we examined effect of on in mice transient middle artery...
As one of the most widely used materials, plastic polymer fragments can abrasively degrade into microplastic (MP) and smaller nanoplastic (NP) particles. The present study aimed to investigate influence particle size on neurodevelopmental toxicity induced by polystyrene nanoplastics (PS-NPs) in Caenorhabditis elegans explore underlying potential mechanism. C. were exposed different concentrations PS-NPs with various sizes (25, 50, 100 nm) for 72 h. Our results showed that all these could...
Lymphocytes play an important role in the immune response after stroke. However, our knowledge of circulating lymphocytes ischemic stroke is limited. Herein, we collected blood samples clinical patients to detect change from admission 3 months by flow cytometry. A total 87 healthy controls and 210 were enrolled, percentages T cells, CD4 + CD8 double negative cells (DNTs), regulatory (Tregs), Tregs, B (Bregs) measured. Among patients, Bregs Tregs increased significantly, while dropped soon...
Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for detrimental effects and cell types involved remain unknown, which may hinder development of specific targeting strategies that boost therapeutic efficacy while minimizing side effects. Microglia important mediators post-TBI neuroinflammation critically impact TBI outcome. HDAC3 was reported be essential inflammatory program...
Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), key player in various central nervous system (CNS) diseases, has garnered interest for its potential neuroprotective effects against ischemic stroke and epilepsy when deleted. Nonetheless, the specific impact of ASK1 on TBI underlying mechanisms remain elusive. Notably, mutation ATP-binding sites, such as lysine residues, can lead to...
Background: Stroke is the second leading cause of death in human life health, but current treatment strategies are limited to thrombolytic therapy, and because tight time window, many contraindications, only a very small number people can benefit from it, new therapeutic needed solve this problem. As physical barrier between central nervous system blood, blood-brain (BBB) maintains homeostasis system. Maintaining integrity BBB may emerge as strategy. Liquiritin (LQ) flavonoid isolated...
Autophagy is a promising target for promoting neural regeneration, which essential sensorimotor recovery following traumatic brain injury (TBI). Whether neuronal heat shock protein B2 (HSPB2), small molecular protein, reduces and promotes TBI remains unclear. In this study, we demonstrated that HSPB2 was significantly increased in the neurons of mouse model, patients, primary neuron cultures subjected to oxygen/glucose deprivation reperfusion treatment. Upon creating tamoxifen-induced...
ABSTRACT Aims Caloric restriction is a health‐promoting lifestyle that has been reported to protect both white and gray matter in cases of ischemic stroke. This study will explore the underlying mechanism restricted feeding (RF) provide theoretical basis for precise clinical treatment Methods In this study, we pretreated C57BL/6J mice with 70% RF continuous 28‐day period prior 60 min transient focal cerebral ischemia (tFCI). Histological staining, diffusion tensor imaging (DTI), behavioral...
Forest ecosystems are crucial in mitigating air pollution and improving quality. Therefore, investigating the relationships between quality, forest structure, environmental factors different types is of significant importance. This study conducted three months continuous monitoring (June–September 2023) quality (particulate matter (PM2.5 PM10), ozone (O3), negative ions (NAI)) (air temperature (TA), relative humidity (RH), light intensity (LI), wind speed (WS)) four subtropical types, along...
Previous studies suggested that anti-inflammatory microglia/macrophages (Mi/MΦ) play a role in "normal phagocytosis," which promoted the rapid clearance of necrotic substances and apoptotic cells. More recently, few have found Mi/MΦ also "pathological phagocytosis" form excessive or reduced phagocytosis, thereby worsening damage induced by CNS diseases. However, underlying mechanisms subtypes related to this pathological phagocytosis are still unknown. Salt-inducible kinase 3 (SIK3), member...
Compared to men, women often develop COPD at an earlier age with worse respiratory symptoms despite lower smoking exposure. However, most preventive, and therapeutic strategies ignore biological sex differences in COPD. Our goal was better understand sex-specific gene regulatory processes lung tissue the molecular basis for onset severity. We analyzed expression DNA methylation data from 747 individuals Lung Tissue Research Consortium (LTRC), 85 independent dataset. identified...
The Class-I histone deacetylases (HDACs) mediate microglial inflammation and neurological dysfunction after traumatic brain injury (TBI). However, whether the individual HDACs play an indispensable role in TBI pathogenesis remains elusive. HDAC2 has been shown to upregulate pro-inflammatory genes myeloid cells under injuries such as intracerebral hemorrhage, thereby worsening outcomes. Thus, we hypothesized that drives microglia toward a neurotoxic phenotype murine model of controlled...
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous, chronic inflammatory process of the lungs and, like other complex diseases, caused by both genetic and environmental factors. Detailed understanding molecular mechanisms diseases requires study interplay among different biomolecular layers, thus integration omics data types. In this study, we investigated COPD-associated through correlation-based network lung tissue RNA-seq DNA methylation COPD cases (n = 446) controls 346)...