Christian R. Pangilinan

ORCID: 0000-0003-3913-7912
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About
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Research Areas
  • Cancer Research and Treatments
  • Nanoplatforms for cancer theranostics
  • Autophagy in Disease and Therapy
  • Infection Control in Healthcare
  • Essential Oils and Antimicrobial Activity
  • Synthesis of Organic Compounds
  • Phagocytosis and Immune Regulation
  • Skin Protection and Aging
  • Plant-Microbe Interactions and Immunity
  • Transgenic Plants and Applications
  • Ginger and Zingiberaceae research
  • Korean Peninsula Historical and Political Studies
  • Proteoglycans and glycosaminoglycans research
  • Radiation Therapy and Dosimetry
  • Connexins and lens biology
  • Retinoids in leukemia and cellular processes
  • Plant Pathogens and Fungal Diseases
  • Plant tissue culture and regeneration
  • Marine Sponges and Natural Products
  • Aquaculture disease management and microbiota
  • Phytochemistry and Biological Activities
  • Redox biology and oxidative stress
  • Natural product bioactivities and synthesis
  • Migration, Ethnicity, and Economy
  • Antimicrobial Peptides and Activities

The Wistar Institute
2023-2025

National Sun Yat-sen University
2019-2022

Manila Central University
2017-2018

Pampanga State Agricultural University
2015

Immunotherapy is becoming a popular treatment modality in combat against cancer, one of the world's leading health problems. While tumor cells influence host immunity via expressing immune inhibitory signaling proteins, some bacteria possess immunomodulatory activities that counter symptoms tumors. The accumulation Salmonella sites influences protein expression, resulting T cell infiltration. However, molecular mechanism by which activates remains elusive. Many tumors have been reported to...

10.3390/cancers12010057 article EN Cancers 2019-12-24

Heparanase cleaves the extracellular matrix by degrading heparan sulfate that ultimately leads to cell invasion and metastasis; a condition causes high mortality among cancer patients.Many of anticancer drugs available today are natural products plant origin, such as hinokitiol.In previous report, it was revealed hinokitiol plays an essential role in anti-inflammatory anti-oxidation processes promote apoptosis or autophagy resulting inhibition tumor growth differentiation.Therefore, this...

10.7150/ijms.41177 article EN cc-by-nc International Journal of Medical Sciences 2020-01-01

Thyroid cancer has been known as the most common endocrine malignancy. Although majority of thyroid types respond well to conventional treatment including surgery and radioactive iodine therapy, about 10% those with differentiated will present distant metastasis have persistent or recurrent disease. Even more serious is a rare type called anaplastic (ATC), which accounts for 1%, demonstrated lethal aggressive form human Unfortunately, these tumors are also frequently resistant traditional...

10.7150/jca.75163 article EN cc-by-nc Journal of Cancer 2022-01-01

Context: The study investigated the medicinal properties of Spathiphyllum cannifolium (Dryand. ex Sims) Schott as a possible source antimicrobial compounds. Materials and Methods: phytochemical constituents were screened using qualitative methods antibacterial antifungal activities determined agar well diffusion method. Statistical Analysis: One-way analysis variance Fisher's least significant difference test used. Results: screening showed presence sterols, flavonoids, alkaloids, saponins,...

10.4103/jpbs.jpbs_95_17 article EN cc-by-nc-sa Journal of Pharmacy And Bioallied Sciences 2018-01-01

Chemotherapy is now in common use for the treatment of tumors; however, with tumor growth retardation comes severe side effects that occur after a chemotherapy cycle.Eicosapentaenoic acids (EPA) used combination has an additive and provides rationale using EPA tandem chemotherapy.To improve efficacy safety this therapy, further understanding modulates microenvironment necessary.Connexin 43 (Cx43) involved enhancing chemosensitivity was suppressed microenvironment.We aim to investigate role...

10.7150/ijms.30889 article EN cc-by-nc International Journal of Medical Sciences 2019-01-01

Targeting metastasis is a vital strategy to improve the clinical outcome of cancer patients, specifically in cases with high-grade malignancies. Here, we employed Salmonella-based treatment address metastasis. The potential Salmonella as an anticancer agent has been extensively studied; however, mechanism through which it affects remains unclear. This study found that epithelial-to-mesenchymal transition (EMT) inducer SNAI1 was markedly reduced Salmonella-treated melanoma cells, revealed by...

10.3390/cancers13122894 article EN Cancers 2021-06-09

Chemotherapy is a treatment method commonly used for cancer and that patients showing low to no response the often developed drug resistance via multiple mechanisms. Natural products have been shown reduce tumor resistance. Hinokitiol, natural tropolone derivative, has potential as an antitumor agent. To improve efficacy safety of hinokitiol, further understanding hinokitiol interactions with microenvironment necessary. The presence plasma membrane multidrug protein P-glycoprotein (P-gp)...

10.7150/jca.69449 article EN cc-by-nc Journal of Cancer 2022-01-01

Robust antimicrobial coatings featuring high transparency, strong bactericidal activity, and an easy application procedure on generic surfaces can be widely accepted by the public to prevent pandemics. In this work, we demonstrated hand-sprayer-based approach deposit complex oxide composed of Co-Mn-Cu-Zn-Ag screen protectors smartphones through acidic redox-assisted deposition (ARD). The as-obtained possess transparency (99.74% transmittance at 550 nm) long-lasting durability against swiping...

10.1021/acs.langmuir.2c02604 article EN Langmuir 2022-11-23

This descriptive research was undertaken to unveil the perception of local farmers in Magalang, Pampanga towards GM crops with aid a written survey instrument administered respondents from February March 2014.In general, it observed that despite inadequate information regarding crops, their implication and impact on human health, environment economy, ambivalent view about improved nutritional quality other health benefits consider safe for consumption solution food security. The are very...

10.14419/ijsw.v3i2.4688 article EN cc-by International Journal of Scientific World 2015-06-01

Introduction: The study was carried out to isolate and identify potential antibiotic-producing bacteria associated with water cabbage (Pistia stratiotes) roots collected from Pampanga River, Pampanga, Philippines. Seven (7) bacterial colonies were randomly chosen at the 10-6 dilution factor. Antibiotic sensitivity test using agar well method revealed that only one of 7 selected can inhibit growth organisms. Specifically, (namely T4) supernatant inhibited E. coli B. subtilis but not S....

10.5530/pj.2018.1.34 article EN cc-by Pharmacognosy Journal 2017-11-26

Abstract The expression of EMT inducer Snail in many cancer types has been implicated high-grade malignancies and correlated with poor prognosis. Tumor-intrinsic not only direct effects on metastasis but also impacts tumor microenvironment by altering secretomes. Our previous reports demonstrated that systemic administration Salmonella significantly reduced growth metastatic nodules tumor-bearing mice, part, coaxing changes the microenvironment. These led us to hypothesize targets inducers....

10.1158/1538-7445.am2020-5031 article EN cc-by-nc Cancer Research 2020-08-15

Robust antimicrobial coatings featuring high transparency, strong bactericidal activity, and easy application procedure on generic surfaces can be widely accepted by the public to prevent pandemics. In this work, we demonstrated hand sprayer-based approach deposit complex oxide composed of Co-Mn-Cu-Zn-Ag screen protectors smartphones through acidic redox-assisted deposition (ARD). The as-obtained possess transparency (99.74% transmittance at 550 nm) long-lasting durability against swiping...

10.26434/chemrxiv-2022-6jkg0 preprint EN cc-by 2022-07-11

Robust antimicrobial coatings featuring high transparency, strong bactericidal activity, and easy application procedure on generic surfaces can be widely accepted by the public to prevent pandemics. In this work, we demonstrated hand sprayer-based approach deposit complex oxide composed of Co-Mn-Cu-Zn-Ag screen protectors smartphones through acidic redox-assisted deposition (ARD). The as-obtained possess transparency (99.74% transmittance at 550 nm) long-lasting durability against swiping...

10.26434/chemrxiv-2022-6jkg0-v2 preprint EN cc-by 2022-11-09
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