A5071631536- Herpesvirus Infections and Treatments
- Infectious Diseases and Tuberculosis
- Autoimmune Neurological Disorders and Treatments
- Traditional Chinese Medicine Studies
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Pharmacological Effects of Natural Compounds
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
- Cerebrovascular and Carotid Artery Diseases
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Acute Ischemic Stroke Management
- Cytomegalovirus and herpesvirus research
- Genomics and Rare Diseases
- Neurological Disease Mechanisms and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Rheumatoid Arthritis Research and Therapies
Third Xiangya Hospital
2021-2023
Central South University
2021-2023
Shanxi Province Hospital of Traditional Chinese Medicine
2013
Shanxi University of Traditional Chinese Medicine
2013
Shanxi Datong University
2013
To explore the autoimmune response and outcome in central nervous system (CNS) at onset of viral infection correlation between autoantibodies viruses. Methods A retrospective observational study was conducted 121 patients (2016–2021) with a CNS confirmed via cerebrospinal fluid (CSF) next-generation sequencing (cohort A). Their clinical information analysed CSF samples were screened for against monkey cerebellum by tissue-based assay. In situ hybridisation used to detect Epstein-Barr virus...
This study provides significant new data on the application of metagenomic next-generation sequencing (mNGS) to clinical diagnostics central nervous system (CNS) viral infections, which can have high mortality rates and severe sequelae. Conventional diagnostic procedures for identifying viruses be inefficient rely preconceived assumptions about pathogen, making mNGS an appealing alternative. However, effectiveness is affected by presence human DNA contamination, minimized using cell-free...
Varicella-zoster virus (VZV) is one of the most common etiologies viral meningitis/encephalitis. The early clinical manifestations and cerebrospinal fluid (CSF) changes VZV meningitis/encephalitis lack specificity, it easy to be misdiagnosed as other encephalitides or tuberculous meningitis. This study aims investigate whether characteristics, CSF analysis findings, cytokine levels could distinguish from central nervous system (CNS) herpes simplex (HSV)
Abstract TMEM151A , located at 11q13.2 and encoding transmembrane protein 151A, was recently reported as causative for autosomal dominant paroxysmal kinesigenic dyskinesia (PKD). Here, through comprehensive analysis of sporadic familial cases, we expand the clinical mutation spectrum PKD. In doing so, clarify genetic features Chinese PKD patients harboring variants further explore relationship between mutations Whole exome sequencing performed on 26 nine pedigrees without PRRT2 variants....
Background: In clinical practice, autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) and tuberculous meningitis (TBM) are difficult to discriminate. Many GFAP-A patients have been misdiagnosed as TBM unnecessarily administered antituberculosis therapy. This study aimed establish a diagnostic model that could distinguish between TBM.Methods: We conducted an observational on multi-center data from 396 73 control patients. randomly divided our dataset into validation training...
Objective To explore the clinical application value of blood routine examination in judgment activity inflammatory bowel diseases. Methods 102 patients with disease were selected as main research objects, 60 healthy persons same period control group, all subjects received testing blood, C-reactive protein and erythrocyte sedimentation rate, relationships between indexes compared. Results In UC PLT, WBC RDW index levels remission higher than those differences statistically...