A5101615099- Plant Growth Enhancement Techniques
- Phosphodiesterase function and regulation
- Plant Physiology and Cultivation Studies
- Receptor Mechanisms and Signaling
- Date Palm Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Plant tissue culture and regeneration
- Computational Drug Discovery Methods
- Evaluation and Performance Assessment
- Algorithms and Data Compression
- Protein Kinase Regulation and GTPase Signaling
- Text and Document Classification Technologies
- Flowering Plant Growth and Cultivation
- Bioinformatics and Genomic Networks
- T-cell and B-cell Immunology
- Nanocomposite Films for Food Packaging
- Biopolymer Synthesis and Applications
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Fiber Laser Technologies
- Silicon Effects in Agriculture
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry Medicinal Plant Applications
- Ubiquitin and proteasome pathways
- Immunodeficiency and Autoimmune Disorders
University of Eastern Finland
2023-2025
University of Gothenburg
2023
University of Connecticut
2004-2009
University of Glasgow
2005-2008
Minia University
2002
PDE4B and PDE4D provide >90% of PDE4 cAMP phosphodiesterase activity in human embryonic kidney (HEK293B2) cells. Their selective small interference RNA (siRNA)-mediated knockdown potentiates isoprenaline-stimulated protein kinase A (PKA) activation. Whereas endogenous co-immunoprecipitates with βarrestin, does not, even upon knockdown. Ectopic overexpression PDE4B2 confers co-immunoprecipitation βarrestin. Knockdown PDE4D, but not PDE4B, amplifies phosphorylation the β2-adrenergic receptor...
The cAMP-specific phosphodiesterase PDE4D5 can interact with the signalling scaffold proteins RACK (receptors for activated C-kinase) 1 and β-arrestin. Two-hybrid co-immunoprecipitation analyses showed that RACK1 β-arrestin in a mutually exclusive manner. Overlay studies scanning peptide array libraries at overlapping sites within unique N-terminal region of distinct conserved PDE4 catalytic domain. Screening alanine substitution arrays, coupled mutagenesis truncation studies, allowed...
We identify a compartmentalized signaling system that identifies functional role for the GTP exchange factor, protein activated by cAMP (EPAC) coupled to Rap2 in nucleus. In this system, regulates nuclear/cytoplasmic trafficking of DNA-dependent kinase (DNA-PK), critical acts repair double-stranded breaks (DSBs) damaged DNA and phosphorylate cell survival kinase, PKB/Akt. Intersecting regulatory inputs employ EPAC transduce positive effects, namely Rap2-dependent nuclear exit activation...
The Patient Similarity Network paradigm implies modeling the similarity between patients based on specific data. can summarize patients’ relationships from high-dimensional data, such as biological omics. end PSN undergo un/supervised learning tasks while being strongly interpretable, tailored for precision medicine, and ready to be analyzed with graph-theory methods. However, these benefits are not guaranteed depend granularity of summarized clarity measure, complexity network’s topology,...
Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired vaccine responses. Autoimmune manifestations are common, but B cell central peripheral selection mechanisms in CVID incompletely understood. Here, we find that receptor editing, measure tolerance, increased transitional cells from patients these have higher immunoglobulin κ:λ ratio with autoimmune than those infection only....
Aims: This study was aimed to produce biodegradable cellulose acetate films impregnated with bacteriocin-like inhibitory substances be used in food packaging.Methodology and results: Bacterial isolates were isolated from different sources tested for their antimicrobial activity by agar well diffusion assay.The isolate that showed the highest against Staphylococcus aureus ATCC 29213, Escherichia coli 51659, Pseudomonas aeruginosa MG847103 Streptococcus mutans 25175 identified as...
Summary: Several papers have been published about the prediction of hepatitis C virus (HCV) polyprotein cleavage sites, using symbolic and non-symbolic machine learning techniques. The achieved different Levels accuracy. results depends on used technique availability adequate accurate HCV sequences with known sites. We tried here to achieve more results, Informative knowledge protein sites Decision tree algorithm. There are several factors that can affect overall One most important is...
We propose a novel design of commercially realizable BOFDR system with new perspective on the signal processing that relies digital envelope detection to increase spatial resolution and spectral Brillouin gain spectra spontaneous scattering sinusoidally, amplitude modulated pump laser.
In this paper we present a survey of techniques and strategies that can be utilized to process high-volumes data in support counter-terrorism. Data reduction is critical problem for counter-terrorism; there are large collections documents must analyzed processed, raising issues related performance, lossless reduction, polysemy (i.e., the meaning individual words being influenced by their surrounding words), synonymy possibility same term described different ways). Our main objective provide...
During 2015 and 2016 seasons, Zebda mango trees treated once (at the beginning of growth), twice growth again just after fruit setting), or thrice start, setting at one month later) with Royal Jelly 0.0125 up to 0.05 %. The effects jelly treatments on fruiting were investigated. Treating once, twice, 0.05% caused a remarkable promotion all characteristics, leaf pigments various nutrients, yield as well both physical chemical characteristics fruits compared control treatment. There was...
Abstract Fuel cells, as highly efficient and environment-friendly power sources, have attracted ever-increasing research development in the past few decades. Mathematical modeling simulation are applied to examine influence of different physical electrochemical phenomena occurring structure fuel cell during operation. Such programs take a very long time (of order days or even weeks) run, especially when accurate results called for. To achieve more insight, we need complex models (two-...
Abstract INTRODUCTION: The androgen receptor (AR) dysfunctions contribute to prostate cancer (CaP) development and progression. Earlier we defined the regulation of AR protein levels by a negative feed-back loop between regulated PMEPA1, NEDD4 E3 ubiquitin ligase binding protein. Our data also revealed decreased or absent PMEPA1 transcripts in 65% tumors. This study focuses on relationship with its transcriptional targets (PSA) human CaP, as well impact silencing growth PMEPA1-shRNA LNCaP...
The present investigation was carried out during 2017 and 2018 seasons.Barhee date palms grown under Aswan region conditions produced via tissue culture received three sprays of four plant extracts namely oils moringa, garlic onion extract green tea each at 0.05 to 0.2%.The merit elucidating the effect these on fruiting setting, yield fruit quality.Carrying garlic, 0.2% had an announced promotion quality relative control treatment.Using extract, in ascending order very effective promoting...