A5115594891- Systemic Lupus Erythematosus Research
- Acute Myeloid Leukemia Research
- Smart Grid Energy Management
- Electric Power System Optimization
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Dementia and Cognitive Impairment Research
- Chromosomal and Genetic Variations
- Catalytic Processes in Materials Science
- Air Quality and Health Impacts
- Electrocatalysts for Energy Conversion
- T-cell and Retrovirus Studies
- Erythrocyte Function and Pathophysiology
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Hematopoietic Stem Cell Transplantation
- Neurological Disease Mechanisms and Treatments
- Cancer and Skin Lesions
- interferon and immune responses
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Surgical Sutures and Adhesives
- Cytomegalovirus and herpesvirus research
- Electrochemical Analysis and Applications
Sichuan University
2016-2025
Harbin Medical University
2024-2025
Shanghai Jiao Tong University
2015-2024
Shanghai Zhangjiang Laboratory
2024
Dalian Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Institute of Hematology & Blood Diseases Hospital
2024
China Medical University
2024
Qingdao University
2024
Shanghai Sixth People's Hospital
2024
Abstract Introduction Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. The aim this study was to detect the levels four (ENST00000500949: linc0949, ENST00000500597: linc0597, ENST00000501992: linc1992, ENST00000523995: linc3995) involved innate immunity peripheral blood mononuclear cells...
Type I interferon (IFN) is a critical pathogenic factor during the progression of lupus nephritis (LN). Although microRNAs (miRNAs) have been shown to control IFN response in immune cells LN, role miRNAs resident renal remains unclear. We undertook this study investigate microRNA-130b (miR-130b) pathway as well its therapeutic effect LN.Kidney tissues from patients and (NZB × NZW)F1 lupus-prone mice were collected for detecting miR-130b levels. Primary mesangial (RMCs) used determine...
Organoids are approved by the US FDA as an alternative to animal experiments guide drug development and for sensitivity screening. Stable organoids models of gastric cancer desirable personalized medicine Tumor tissues from a primary stomach metastatic lymph node were collected 3D culture. By long-term culture over 50 generations in vitro, we obtained stably growing organoid lines. We analyzed short tandem repeats (STRs) karyotypes cells, tumorigenesis nude mice, well multi-omics profiles...
Objective Type I interferon (IFN) signaling is regarded as a central pathogenic pathway in systemic lupus erythematosus (SLE). Specific inhibition of this core area for the development new therapies SLE. This study was undertaken to clarify mechanism involved and identify therapeutic targets, using high‐throughput screening platform determine novel regulators that contribute overactivation type IFN Methods A IFN‐stimulated response element (ISRE)–luciferase assay used screen candidate genes...
Abstract Background The physical function of elderly individuals reflects whether they have had a history regular activity over the long term. Such indicators been found to certain connection with cognitive these years. However, there is limited research that associates it mechanisms such as cerebral Aβ deposition. We aim investigate this relationship and unveil underlying mechanisms. Method Physical cognition data 4189 participants were obtained from Chinese preclinical Alzheimer's disease...
Abstract Renal mesangial cells (RMCs) constitute a population of in glomerular mesangium. Inflammatory cytokines produced by RMCs play vital role renal inflammation. miRNAs are key regulators inflammatory cytokine expression. The abnormal expression and the consequent changes signal transduction closely associated with However, our knowledge functions is still limited. In this study, we investigated miR-744 type I interferon (IFN) signaling pathway primary human RMCs. We show that...
Unique Co 3 O 4 /Fe 0.3 0.7 P heterostructures with abundant interfaces were elaborately designed and fabricated as effective electrocatalysts for the urea oxidation reaction.
The rapid growth of energy demand has put tremendous pressure on the power system. In order to ease system and balance supply in peak periods, we devise an integrated response (IDR) program by taking different types consumers into consideration. Different from most existing works that model responsive without classification, classify clusters using method k-means. Based classification result, models are obtained through historical data. proposed IDR is modeled as a nonlinear programming...
This study aims to establish a new prognostic index using machine learning models predict the clinical outcomes of triple-negative breast cancer (TNBC) patients receiving neoadjuvant therapy. In this study, we collected data from electronic medical records system Harbin Medical University Cancer Hospital training set 501 who received therapy January 2017 December 2021. Additionally, Affiliated Hospital, Second and Sixth validation 1533 during same period. All underwent blood tests, following...
INTRODUCTION AND AIMS: Conflicting data exists on the role of complement lectin pathway and its recognition molecules in disease progression IgA nephropathy (IgAN), underlying mechanism is not elucidated.The aim this study to investigate associations underline variations mannose binding (MBL), L-ficolin IgAN based an extend cohort Chinese patients.METHODS: we enrolled 613 patients carried out a two stage genetic study.Renal outcomes were defined as End-stage renal (ESRD; dialysis or...