A5012405309- RNA modifications and cancer
- Animal Virus Infections Studies
- RNA Research and Splicing
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Advanced Cellulose Research Studies
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Quality Function Deployment in Product Design
- Advanced Decision-Making Techniques
- Polymer Nanocomposites and Properties
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Biomedical Research and Pathophysiology
- Eosinophilic Esophagitis
- Immune cells in cancer
- Viral gastroenteritis research and epidemiology
- Flow Measurement and Analysis
- Dielectric materials and actuators
- Neuroinflammation and Neurodegeneration Mechanisms
- Simulation and Modeling Applications
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Renal and related cancers
Shanghai University
2021-2023
Shanghai Jiao Tong University
2020-2023
Hainan University
2022
Shanghai Institute of Organic Chemistry
2017-2020
The First Affiliated Hospital, Sun Yat-sen University
2018-2020
Zhongshan Hospital
2017-2020
Fudan University
2017-2020
Sun Yat-sen University
2018-2020
Shanghai First People's Hospital
2020
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes differing from conventional T in having no antigen-specific receptors. ILCs include natural killer (NK) cells, helper-like ILC1s, ILC2s, and ILC3s, tissue-inducer (LTi) cells. Tumor frequently found various cancers, but their roles cancer immunity immunotherapy remain largely unclear. We report here the single-cell characterization of blood gut ILC subsets healthy conditions colorectal (CRC). The contains ILC3/NKs, ILC2s....
Previous studies imply that telocytes may have a protective effect on fibrosis in various organs, including the liver, colon, and heart. The of renal remains unknown. Herein, this study was designed to investigate potential mechanisms involved.In unilateral ureteral obstruction (UUO)-induced model, were injected via tail vein every other day for 10 days. degree damage determined using histological assessment. expression collagen I, fibronectin, epithelial-mesenchymal transition markers,...
Myeloid-derived suppressor cells (MDSCs) can prevent allograft rejection and induce immune tolerance in transplantation models. Previous studies have demonstrated that inhibition of mTOR signaling enhance the MDSC protective effect heart (HTx) by promoting expansion. In addition, is related to autophagy. The present study investigated mechanism mTOR-deficient monocytic MDSCs (M-MDSCs) mouse HTx. Myeloid-specific conditional knockout mice were generated obtain mTOR-/- M-MDSCs. proliferation...
Fundamental to viral biology is identification and annotation of genes their function. Determining the level coronavirus gene expression inherently difficult due positive stranded RNA genome subgenomic RNAs (sgRNAs) that are required for most genes. We developed a bioinformatic pipeline analyze metatranscriptomic data from 20 independent studies encompassing 588 individual samples 10 species. This comparative analysis defined core sgRNA repertoire SARS-CoV-2 found novel sgRNAs could encode...
In order to avoid the occlusion problems and missing important features of streamlines in flow field, this paper proposes a 3D streamline selection algorithm based on comprehensive similarity. The method starts with hierarchical clustering sets then extracts high similarity their requires calculation distance contour streamlines. paper, Hausdorff is improved by proposing partially matched reduce influence length calculation. Then calculated according ICP algorithm, entropy weighting used...
ABSTRACT The RNA decapping enzyme Dcp2 is a crucial involved in the process of turnover, which can post-transcriptionally regulate gene expression. has been found to be highly expressed embryonic, but not adult, kidneys. Here we showed that mRNA was expressed, proteins were absent, mouse kidneys after postnatal day 10 (P10). In adult Dcp2-IRES-EGFP knock-in mice, undetectable EGFP indicating completely silenced Using luciferase reporter assays, miR-141-3p/200a-3p directly targeted 3ʹ UTR...
ABSTRACT Background Fundamental to viral biology is identification and annotation of genes their function. Determining the level coronavirus gene expression inherently difficult due positive stranded RNA genome sub-genomic RNAs (sgRNAs) that are required for most genes. In COVID-19 epidemic so far, few genomic studies have looked at sgRNAs none systematically examined sgRNA profiles large numbers SARS-CoV2 datasets in conjuction with data other coronaviruses. Results We developed a...
In the visual simulation of surface dust concentration in virtual campus, data each grid point should be obtained. Because points are unknown, so through discrete sample around known properties unknown value interpolation estimation. Therefore, it is very important to select an algorithm that can satisfy requirement accuracy and have high computational efficiency process points. According characteristics campus value, this paper proposes inverse distance mixed for by combining advantages...
The evaluation of software quality involves many factors, therefore it is difficult to get a scientific and reasonable quantitative results. Based on the analysis advantages disadvantages AHP method EM method, this paper proposes fuzzy comprehensive model evaluate system. uses weight calculation based AHP-EM overcome defects single assignment method. By evaluating 3D visualization system web, can be seen that result closer subjective conclusion than results using which proves validity...
With the continuous development of scientific visualization, visualization has been applied to various fields. Flow field is an important part visual field, by using computer graphics, vision, and image processing technology, it can use intuitive graphical images describe flow structure complex, disorder, which makes in meteorology, aviation geography have great application prospect. This paper uses MATLAB App Designer design a software, mainly displays scalar or vector velocity two...