Wan Ting Kong
A5039525966- Immune cells in cancer
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Animal testing and alternatives
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- Fibroblast Growth Factor Research
- Liver Diseases and Immunity
- S100 Proteins and Annexins
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Diabetes and associated disorders
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
Singapore Immunology Network
2019-2024
Agency for Science, Technology and Research
2019-2024
Institut Gustave Roussy
2022-2024
Inserm
2022-2024
La Ligue Contre le Cancer
2022-2023
Université Paris-Saclay
2023
National University of Singapore
2018
Tissue macrophages have a split personality Resident tissue (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and homeostasis. Chakarov et al. used single-cell RNA sequencing fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, ontogeny (see the Perspective by Mildner Yona). In addition alveolar macrophages, they identified two different interstitial...
Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They orchestrators of chronic obstructive pulmonary disease (COPD), with their number significantly increased functions altered in COPD. However, it is unclear how AM function controlled a healthy if changes AMs without environmental assault sufficient to trigger inflammation We report here that absence isthmin 1 (ISM1) mice (Ism1-/- ) leads increase both functional heterogeneity, enduring inflammation,...
Abstract This article is part of the Dendritic Cell Guidelines series, which provides a collection state‐of‐the‐art protocols for preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization mouse human dendritic cells (DC) from lymphoid organs various non‐lymphoid tissues. Recent studies have provided evidence an increasing number phenotypically distinct conventional DC (cDC) subsets that on one hand exhibit certain plasticity, but...