A5028404148- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
- Neurogenesis and neuroplasticity mechanisms
- Cancer Genomics and Diagnostics
- Immune responses and vaccinations
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Renal and related cancers
Weizmann Institute of Science
2019-2023
Aix-Marseille Université
2021-2022
Inserm
2016-2022
Centre National de la Recherche Scientifique
2016-2022
University of Freiburg
2019-2022
Centre d’Immunologie de Marseille-Luminy
2016-2019
Genetic programming for self-renewal Instead of repopulating themselves from tissue-resident stem cell pools like most types differentiated cells, tissue macrophages maintain by self-renewing. The underlying genetic programs that allow this, however, are unknown. Soucie et al. now report in at homeostasis, a pair transcription factors (MafB and c-Maf) bind to repress the enhancers genes regulating self-renewal. When need replenish their stocks, example response injury, they transiently...
Alveolar macrophages (AM) are tissue-resident that colonize the lung around birth and can self-maintain long-term in an adult organism without contribution of monocytes. AM located pulmonary alveoli be harvested by washing lungs using method bronchoalveolar lavage (BAL). Here, we compared different conditions BAL to obtain high yields murine for vitro culture expansion AM. In addition, describe specific conditions, under which proliferate liquid presence granulocyte-macrophage...
Abstract Alveolar macrophages (AM) are tissue resident of the lung that can be expanded in culture, but it is unknown to what extent culture affects their vivo identity. Here we show long-term ex mouse AM (exAM) maintain core gene expression adaptations related adhesion, metabolism and proliferation. Strikingly, even after several months exAM reacquired full transcriptional epigenetic identity upon transplantation into could self-maintain natural niche long-term. Changes open chromatin...