A5024425958- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- CAR-T cell therapy research
- Hemoglobinopathies and Related Disorders
- Fibroblast Growth Factor Research
- Viral Infectious Diseases and Gene Expression in Insects
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Immune cells in cancer
- Acute Kidney Injury Research
- Angiogenesis and VEGF in Cancer
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Hip and Femur Fractures
- Dermatologic Treatments and Research
- Nitric Oxide and Endothelin Effects
- Chronic Kidney Disease and Diabetes
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Pelvic and Acetabular Injuries
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
China Three Gorges Corporation (China)
2025
Xiamen University
2025
Fujian Medical University
2025
Wenzhou Medical University
2015-2024
State Key Laboratory of Natural Medicine
2024
China Pharmaceutical University
2024
Zhongshan Hospital
2014-2022
Shanghai Institute of Organic Chemistry
2014-2021
The First Affiliated Hospital, Sun Yat-sen University
2014-2021
Fudan University
2014-2021
Vascular endothelial growth factor (VEGF) is a heparin-binding, cell-specific mitogen. Previous studies have suggested that VEGF regulator of naturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis angiogenic potential sufficient to constitute therapeutic effect. The soluble 165-amino acid isoform was administered as single intra-arterial bolus internal iliac artery rabbits in which ipsilateral femoral excised induce severe, unilateral hind...
Ischemia-reperfusion injury (IRI) is one of the major causes postoperative renal allograft dysfunction, which mainly result proinflammatory reactions including inflammatory responses, oxidative stress, and metabolic disorders. Resveratrol (RSV) plays an important role in protecting various organs IRI because it reduces lessens response, exerts anti-apoptotic effects. The aim this study was to demonstrate renoprotective effect RSV inhibiting reducing decreasing cell apoptosis vivo vitro.RSV...
Abstract The mammalian target of rapamycin (mTOR) signal controls innate and adaptive immune response in multiple immunoregulatory contexts. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population myeloid potent immunosuppressive capacity. In this study, we aimed to investigate the role MDSCs protection acute kidney injury (AKI) regulation mTOR on MDSC’s protective context. mice AKI model, administration was associated with improved renal function, restored histological...
Abstract Erythropoietin (EPO) is a well-known hormone that clinically used for the treatment of anemia. Very recently, an increasing body evidence showed EPO could still regulate bioactivities macrophages. However, details about immunomodulatory effect on macrophages are not fully delineated, particularly in setting renal damages. Therefore, present study, we determined whether exert impact dynamics well-established model rhabdomyolysis-induced acute kidney injury and explored potential...
To study whether endogenous endothelial progenitor cells (EPCs) are involved in neovascularization after stroke.Animal stroke models were established by subjecting male SD rats to permanent middle cerebral artery occlusion (pMCAO). Vessels ischemic boundary zone (IBZ) stained with antibody against laminin at 1 21 days pMCAO. EPCs and newly formed vessels identified staining special markers. After inhibiting recruitment of AMD3100, a CXCR4 antagonist, EPCs, capillary density, blood flow (CBF)...
Renal ischemia-reperfusion injury plays a key role in renal transplantation and greatly affects the outcome of allograft. Our previous study proved that Baicalin, flavonoid glycoside isolated from Scutellaria baicalensis, protects kidney injury. This aimed to underlying mechanism vitro. Human proximal tubular epithelial cell line HK-2 cells were stimulated by H2O2 with without Baicalin pretreatment. The viability, apoptosis oxidative stress level measured. expression endoplasmic reticulum...
Mesenchymal stem cell (MSC) has been widely explored in the past decade as a cell-based treatment for various diseases. However, poor survival of adaptively transferred MSCs limits their clinical therapeutic potentials, which is largely ascribed to nutrient starvation. In this study, we determined whether novel kidney protective peptide CHBP could protect against starvation and invested underlying mechanisms. were subjected serum deprivation graded concentrations was administered. Cell...
Complement activation is involved in the pathogenesis of ischemia reperfusion injury (IRI), which an inevitable process during kidney transplantation. Therefore, complement-targeted therapeutics hold great potential protecting allografts from IRI. We observed universal deposition C3d and membrane attack complex human renal with delayed graft function or biopsy-proved rejection, confirmed involvement complement Using
Abstract Purpose: The murine Lym-1 mAb targets a discontinuous epitope (Lym-1 epitope) on several subtypes of HLA-DR, which is upregulated in majority human B-cell lymphomas and leukemias. Unlike CD19, the does not downregulate upon crosslinking, may provide an advantage as target for CAR T-cell therapy. T cells with conventional 4-1BB CD3ζ (BB3z) signaling domain exhibited impaired ex vivo expansion. This study aimed to identify underlying mechanisms develop strategies overcome this effect....
The offshore wind industry is increasingly moving towards larger turbines. growth in rotor size and aerodynamic loads necessitates monopile foundations. This increased foundation height results a that exhibits pronounced slenderness flexibility. Consequently, the fixed-bottom becomes more susceptible to wave loads, which can induce nonlinear vibrations complex environments. Extensive physical model experiments have been conducted tank study vibration characteristics of under regular action....
Chronic pancreatitis (CP) is an inflammatory disease of progressive pancreatic fibrosis, and stellate cells (PSCs) are key involved in fibrosis. To date, there no clinical therapies available to reverse damage or fibrosis associated with CP. Sodium Aescinate (SA) a natural mixture triterpene saponins extracted from the dried ripe fruits horse chestnut tree. It has been shown have anti-inflammatory anti-edematous effects. This study aims explore therapeutic potential SA CP molecular mechanism...
Previous studies have demonstrated the potential antifibrotic effects of baicalin in vitro, via examination 21 compounds isolated from plants. However, its biological activity and underlying mechanisms action vivo remain to be elucidated. The present study aimed evaluate effect on renal fibrosis vivo, signaling pathways involved. A unilateral ureteral obstruction (UUO)‑induced model was established using Sprague‑Dawley rats. Baicalin administrated intraperitoneally every 2 days for 10 days....
Previous studies imply that telocytes may have a protective effect on fibrosis in various organs, including the liver, colon, and heart. The of renal remains unknown. Herein, this study was designed to investigate potential mechanisms involved.In unilateral ureteral obstruction (UUO)-induced model, were injected via tail vein every other day for 10 days. degree damage determined using histological assessment. expression collagen I, fibronectin, epithelial-mesenchymal transition markers,...
Abstract Background Intracarotid injection of mannitol has been applied for decades to support brain entry therapeutics that otherwise do not effectively cross the blood–brain barrier (BBB). However, elaborate and high-risk nature this procedure kept its use restricted well-equipped medical centers. We are developing a more straightforward approach safely open BBB, based on intra-arterial (IA) NEO100, highly purified version natural monoterpene perillyl alcohol. Methods In vitro permeability...
Motor-sparing regional anesthesia modalities, such as periarticular infiltration (PAI) and pericapsular nerve group (PENG) block, have become the mainstay of multimodal approaches used during total hip arthroplasty (THA). We hypothesized that postoperative analgesia PENG block was non-inferior to PAI.Sixty patients were randomly allocated into two groups. The PAI injected with 100 mL cocktail solution (ropivacaine 20 mL, ketorolac 2 epinephrine 1 mixed normal saline) in tissues directly by...
Background The definition of deep tissue injury was derived from multiple clinical cases as "A purple or maroon localized area discolored intact skin blood-filled blister due to damage underlying soft pressure and/or shear". Acidic fibroblast growth factor (aFGF) significantly improves wound healing under diabetic conditions. However, date, the therapeutic application aFGF has been limited, its low delivery efficiency and short half-life. Methodology/Principal Findings Using an animal model...
The purpose of this study was to determine the prevalence symptomatic femoroacetabular impingement (FAI) in athletic patients.From July 2003 May 2013, 388 patients (422 hips) who underwent arthroscopic surgery for FAI were evaluated demographic characteristics. patients' age, gender, diagnosis, and type sports analyzed using medical records radiography.Among 422 hips patients, 156 involved with sports. Among hips, 86, 43, 27 categorized as cam, pincer, mixed type, respectively. Types soccer,...
Bromodomain-containing protein 4 (BRD4) is the most promising target for treatment of triple-negative breast cancer (TNBC). However, its inherent resistant and acquired drug resistance limits potential clinical application. Recently it has been shown that cyclin-dependent kinases 4/6 (CDK4/6) inhibitors can reincrease sensitivity TNBC cells to BRD4 by combination therapy, so we designed a series dual CDK6/BRD4 inhibitors. Among newly synthesized compounds,
NKT cells play a protective role in ischemia reperfusion (IR) injury, of which the trafficking body and recruitment injured organs can be influenced by immunosuppressive therapy. Therefore, we investigated effects rapamycin on kidneys exposed to IR injury early stage murine model.Balb/c mice were subjected kidney 30 min followed 24 h reperfusion. Rapamycin (2.5 ml/kg) was administered gavage daily, starting 1 day before operation. Renal function histological changes assessed. The proportion...