A5036663904- Foot and Ankle Surgery
- Lower Extremity Biomechanics and Pathologies
- Diabetic Foot Ulcer Assessment and Management
- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Erythropoietin and Anemia Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Sports injuries and prevention
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Bone fractures and treatments
- Glioma Diagnosis and Treatment
- Renin-Angiotensin System Studies
- PARP inhibition in cancer therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Polymer Synthesis and Characterization
- Renal Transplantation Outcomes and Treatments
- Lung Cancer Diagnosis and Treatment
- Dendrimers and Hyperbranched Polymers
- Eicosanoids and Hypertension Pharmacology
- Cell death mechanisms and regulation
- Teratomas and Epidermoid Cysts
- Skin Diseases and Diabetes
Fudan University
2016-2025
Huashan Hospital
2013-2025
The First Affiliated Hospital, Sun Yat-sen University
1997-2024
Sun Yat-sen University
1997-2024
Anhui Medical University
2024
Beijing Institute of Education
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
First People's Hospital of Chongqing
2024
Henan Provincial Institute of Cultural Heritage and Archaeology
2024
Opera Software (Norway)
2024
Abstract Erythropoietin (EPO) is a well-known hormone that clinically used for the treatment of anemia. Very recently, an increasing body evidence showed EPO could still regulate bioactivities macrophages. However, details about immunomodulatory effect on macrophages are not fully delineated, particularly in setting renal damages. Therefore, present study, we determined whether exert impact dynamics well-established model rhabdomyolysis-induced acute kidney injury and explored potential...
Telocytes (TCs), a distinct type of interstitial cells, have been identified in many organs via electron microscopy. However, their precise function organ regeneration remains unknown. This study investigated the paracrine effect renal TCs on tubular epithelial cells (TECs) vitro, regenerative tubules after ischaemia-reperfusion injury (IRI) vivo and possible mechanisms involved. In IRI model, transplantation was found to decrease serum creatinine blood urea nitrogen (BUN) levels, while...
FMS-like tyrosine kinase 3 (FLT3) inhibitors (TKIs) have activity in acute myeloid leukemia (AML) patients with FLT3 internal tandem duplication (ITD) mutations, but efficacy is limited by resistance-conferring domain mutations. This phase 1/2 study evaluated the safety, tolerability, and of oral inhibitor PLX3397 (pexidartinib), which has against TKI-resistant F691L gatekeeper mutation relapsed/refractory FLT3-ITD-mutant AML. Ninety were treated: 34 dose escalation (part 1) 56 expansion 2)....
A continuous anionic living process for the fast synthesis of dendrimer-like star polymers is described. The based on selective addition sec-butyllithium (s-BuLi) toward 1,3-bis(1-phenylethenyl)benzene (MDDPE), which gives stoichiometric monoadduct in tetrahydrofuran (THF). monoadduct, an inimer-like molecule, then used as branching agent polymers. Thus, α,ω-bifunctional polystyryllithium (G1.0), initiated by a difunctional initiator, undergoes reaction with to form tetrafunctional species,...
Various operative procedures have been reported for the treatment of Müller-Weiss disease (MWD). This study reports midterm results stages II to V MWD with derotation talus and arthrodesis.Thirty-four patients (36 feet) were treated by talonavicular (TN) or talonavicular-cuneiform (TNC) arthrodesis in our center from 2008 2015. The affected feet staged according Maceira staging system (stage II: 9; stage III: 10; IV: V: 8). American Orthopaedic Foot & Ankle Society (AOFAS) midfoot scale,...
Understanding the morphological variability of distal tibia can help design tibial components total ankle implants. This study aimed to assess shape bone, utilizing statistical modeling (SSM) technique. A 229 bones were analyzed through CT scans develop SSM models. Principal component analysis (PCA) was employed characterize variation across male, female, and overall groups. The geometric parameters resected surfaces at 10-mm level above articular surface compared. first seven principal...
Insulin is a potent medication for managing diabetes, yet its short half-life requires daily administration. Currently, Novo Nordisk's icodec the sole insulin available on market that administration only once week. icodec, developed by Nordisk through amino acid mutations and fatty side chain modifications, has demonstrated capability to control blood glucose levels once-weekly basis. To improve efficacy, we modified acylation of generate analogs appropriate weekly dosing. A promising...
Anionic macroinimer is prepared through selective monoaddition of polyisoprenyllithium (PILi) toward 1,3-bis(1-phenylvinyl)benzene (MDDPE) in THF/cyclohexane mixture. The resulting macroinimer, possessing a living anion and diphenylethylene (DPE) group at the same end PI chain, undergoes self-condensing vinyl copolymerization (SCVCP) with styrene after solvent has been switched from mixture into pure cyclohexane. Dendritic block copolymers isoprene are obtained, which chains linked to branch...
Implant loosening in tibia after primary total ankle replacement (TAR) is one of the common postoperative problems TAR. Innovations implant structure design may ideally reduce micromotion at bone-implant interface and enhance fixation initial stability, thus eventually prevents long-term loosening. This study aimed to investigate (1) biomechanical characteristics (2) influence features, such as radius, height, length.A 101 finite-element models were created based on four commercially...
BackgroundIn the central nervous system, glioma is most common malignant tumor, and patients have a poor prognosis. Identification of novel marker genes establishment prognostic models are important for early diagnosis prognosis determination.MethodsDownload data from CGGA TCG databases. Application bioinformatics to analyze impact CYBB on clinicopathological characteristics, immunological features gliomas. Using single-cell sequencing 7 glioblastoma in database, role tumor microenvironment...