A5030104317- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Lymphoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurological Complications and Syndromes
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Spine and Intervertebral Disc Pathology
- Chronic Lymphocytic Leukemia Research
- Spinal Dysraphism and Malformations
- Genetic and Kidney Cyst Diseases
Chuzhou University
2017-2025
Anhui Medical University
2018-2025
Peking University
2016-2025
Fuzhou University
2024-2025
Peking University First Hospital
2025
Weill Cornell Medicine
2019-2024
Fujian Provincial Hospital
2013-2024
Fujian Medical University
2013-2024
Cornell University
2015-2024
Presbyterian Hospital
2015-2024
Background Integration of data from clinical trials and advancements in technology predict a change selection for treatment patients with cerebral aneurysm. Objective To describe patterns use in-hospital mortality associated surgical endovascular treatments aneurysms over the past decade. Materials methods The are 34 899 hospital discharges diagnosis ruptured or unruptured aneurysm 1998 to 2007 identified Nationwide Inpatient Sample (NIS). rates coiling clipping among an examined decade by...
Thrombus characteristics, including Hounsfield unit (HU) value to measure density and thrombus volume length, can predict successful recanalization following IV thrombolysis with recombinant tissue plasminogen activator. Conflicting limited data exist regarding the of assessing properties in acute stroke cases treated endovascular IA approaches.We retrospectively reviewed anterior circulation ischemic which a Solitaire stent retriever (ev3-Covidien) was primary treatment device. We measured...
Utilization of the Pipeline embolization device (PED) in complex ruptured aneurysms has not been well studied. We evaluated safety and effectiveness data from five participating US centers.Records patients with cerebral who underwent PED treatment between 2011 2013 were retrospectively reviewed.26 (mean age 51.4 ± 13.2 years;16 women). At presentation, 8 (30.8%) had a Hunt-Hess grade IV or above; 11 required extraventricular drain placement. Aneurysm morphologies were: dissecting,...
p53 is an essential tumor suppressor, whose activity finely tuned by the posttranslational modifications. Previous research has reported that β-hydroxybutyrate (BHB) induces β-hydroxybutyrylation (Kbhb), which a novel histone modification. Here we report modified kbhb and this modification occurs at lysines 120, 319, 370 of p53. We demonstrate level dramatically increased in cultured cells treated with BHB thymus tissues fasted mice, CBP catalyze kbhb. show results lower levels acetylation...
OBJECT Pessimism exists regarding flow diversion for posterior circulation aneurysms because of reports perforator territory infarcts and delayed ruptures. The authors report the results patients who underwent Pipeline Embolization Device (PED) using novel strategies treatment fusiform aneurysms, compare these with those from previously reported series. METHODS conducted a retrospective review data consecutive vertebrobasilar artery treated PED. RESULTS This resulted in identification 12...
BACKGROUND: Coiling in conjunction with Pipeline embolization device (PED) placement could provide immediate dome protection and an intraaneurysmal scaffold to prevent prolapse for intracranial aneurysms high rupture risk complex anatomy. OBJECTIVE: To report results after treatment of PED coils (PED+coils group) or without (PED-only at a single-institution. METHODS: In this case-controlled study, records patients who underwent between 2011 2013 were retrospectively reviewed. RESULTS:...
BACKGROUND: Utilization of the Pipeline embolization device (PED) to treat distal carotid circulation aneurysms has not been well studied. OBJECTIVE: To report collective experience using PED anterior aneurysms. METHODS: We retrospectively reviewed clinical and radiographic records all patients who underwent at 10 US neurosurgical centers between 2011 2013. RESULTS: Twenty-eight (mean age 51.7 years; 18 women) with 28 were included in analyses. Fifteen fusiform, 5 dissecting, 8 saccular....
Abstract Objectives The aim of this study was to investigate the anti-tumor effect resveratrol (RSV) on glioblastoma (GBM) and its specific mechanism in improving inflammatory response tumor microenvironment. microenvironment GBM is highly neuroinflammatory, inducing immunosuppression. Therefore, ameliorating an important focus for research. Methods RSV demonstrated through vitro cellular assays, including CCK-8, EdU, PI staining, Transwell, wound healing assay, flow cytometry. Potential...
Background: Cerebral aneurysms (CAs) are a significant cerebrovascular ailment with multifaceted etiology influenced by various factors including heredity and environment. This study aimed to explore the possible link between different types of immune cells occurrence CAs. Methods: We analyzed connection 731 cell signatures risk CAs using publicly available genetic data. The analysis included four features, specifically median brightness levels (MBL), proportionate (PC), definite (DC),...
OBJECTIVE: Outcome studies in rodent tumor models rely on both histological and noninvasive study end points. Intracranial require special tools to observe growth over time noninvasively, such as magnetic resonance imaging (MRI), computed tomographic scanning, or cranial window techniques. These techniques share disadvantages terms of cost, technical expertise required, overall animal throughput for analysis. In this report, we sought validate the use relatively newer technique...
Background Integration of data from clinical trials and advancements in technology predict a change selection for treatment patients with cerebral aneurysm. Objective To describe patterns use in-hospital mortality associated surgical endovascular treatments aneurysms over the past decade. Materials methods The are 34 899 hospital discharges diagnosis ruptured or unruptured aneurysm 1998 to 2007 identified Nationwide Inpatient Sample (NIS). rates coiling clipping among an examined decade by...
Object Management of unruptured intracranial aneurysms remains controversial in neurosurgery. The contribution morphological parameters has not been included the treatment paradigm a systematic manner or for any particular aneurysm location. authors present large sample middle cerebral artery (MCA) that were assessed using variables to determine associated with rupture. Methods Preoperative CT angiography (CTA) studies evaluated Slicer software generate 3D models and their surrounding...
Enhancer of zeste homolog 2 (EZH2) is the catalytic unit polycomb repressive complex (PRC2) which epigenetically silences many genes involved in tumor-suppressive mechanisms via trimethylation lysine 27 histone H3 (H3K27me3). We recently found that overexpression EZH2 was associated with poor outcome glioblastoma (GBM). In this study, we examined antitumor effects inhibitor GSK343 on glioma cells vitro and vivo. The proliferation cell cycle measured. Wound healing assay transwell invasion...
Object Growth patterns of pituitary adenomas have been observed to vary by histopathological subtype. The authors aimed analyze variations in the extrasellar extension nonfunctional macroadenomas (NFMAs) and growth hormone (GH)–secreting macroadenomas. Methods A retrospective review was conducted data obtained 75 patients who underwent transsphenoidal operations for histologically confirmed NFMAs (50 patients) GH-secreting (25 at Brigham Women's Hospital over an 18-month period. Patients...
Object Limited data exist to guide management of incidentally discovered pediatric moyamoya. Best exemplified in the setting unilateral moyamoya, which unaffected side is monitored, this phenomenon also occurs populations undergoing routine surveillance cerebral vasculature for other conditions, such as sickle cell disease (SCD) or neurofibromatosis Type 1 (NF1). The authors present their experience with specific syndromic moyamoya better characterize natural history radiographic and...
Flow diversion via Pipeline Embolization Device (PED) represents the most recent advancement in endovascular therapy of intracranial aneurysms. This exploratory study aims at a proof concept for an advanced device-modeling tool conjunction with computational fluid dynamics (CFD) to evaluate flow modification effects by PED actual, treated cases.The authors performed modeling 3 PED-treated complex aneurysm cases. The patient Case 1 had fusiform vertebral single PED. In 2 giant internal...
The aim of this study was to investigate the effects glutamine on histomorphology liver, oxidative stress and nuclear factor-κB (NF-κB) expression in development nonalcoholic fatty liver disease (NAFLD). NAFLD induced rats by a high-fat diet, treatment group were subjected oral administration (1 g/kg/day). Rats from treatment, model normal control groups assessed after 8 12 weeks (n=6 per at each time-point). levels glutathione (GSH), malondialdehyde (MDA) tumor necrosis factor-α (TNF-α)...
Neoplastic meningitis (NM) is a debilitating and increasingly frequent neurological complication of cancer characterized by infiltration tumor cells into the leptomeninges subarachnoid space. Although NM rarely curable, combined intrathecal chemotherapy focal radiation can improve disease-related symptoms survival. Hydrocephalus occurs in significant proportion patients, associated with poor prognosis reduced quality life, usually precludes use therapy.Since January 2005, authors have used...
In contrast to size, the association of morphological characteristics intracranial aneurysms with rupture has not been established in a systematic manner. We present an analysis variables that are associated anterior communicating artery determine site-specific risk variables. One hundred and twenty-four were treated single institution from 2005 2010, CT angiograms (CTAs) or rotational angiography 79 patients (42 ruptured, 37 unruptured) analyzed. Vascular imaging was evaluated 3D Slicer©...
The safe treatment of children using catheter-based angiography and embolization poses unique challenges because the technical factors regarding size fragility access target vessels, as well pediatric cerebrovascular pathologies. complication rates for neurointerventional procedures in have not been established.The records a consecutive cohort patients who underwent neuroangiography and/or between 2007 2013 were reviewed retrospectively to identify both intraprocedural postprocedural...