A5100435291- Traditional Chinese Medicine Analysis
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Crop Yield and Soil Fertility
- Flavonoids in Medical Research
- Plant-based Medicinal Research
- Metabolomics and Mass Spectrometry Studies
- COVID-19 and Mental Health
- Angiogenesis and VEGF in Cancer
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Phytochemistry and Biological Activities
- Psychosomatic Disorders and Their Treatments
- Cell Adhesion Molecules Research
- Long-Term Effects of COVID-19
- Innovative Teaching and Learning Methods
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Lipid metabolism and disorders
- Sarcoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Monoclonal and Polyclonal Antibodies Research
- Scoliosis diagnosis and treatment
Peking University
2021-2025
Peking University Sixth Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Tobacco Research Institute
2022-2025
China Tobacco
2022-2025
Chengdu University of Traditional Chinese Medicine
2025
Yanshan University
2024
Guangdong University of Technology
2024
China Agricultural University
2023
China Academy of Chinese Medical Sciences
2008-2022
Gastrointestinal stromal tumors (GIST) occur primarily in the wall of intestine and are characterized by activating mutations receptor tyrosine kinases genes KIT or PDGFRA. The diagnosis GIST relies heavily on demonstration KIT/CD117 protein expression immunohistochemistry. However, is absent ∼4% to 15% this can complicate patients who may benefit from treatment with kinase inhibitors. We previously identified DOG1/TMEM16A as a novel marker for using conventional rabbit antipeptide antiserum...
ABSTRACT This study aims to elucidate the potential genetic commonalities between metabolic syndrome (MetS) and rheumatic diseases through a disease interactome network, according publicly available large‐scale genome‐wide association studies (GWAS). The analysis included linkage disequilibrium score regression analysis, cross trait meta‐analysis colocalisation identify common overlap. Using modular partitioning, network‐based two proteins in protein–protein interaction set was divided...
The Submillimeter Wave Astronomy Satellite (SWAS), launched in 1998 December, is a NASA mission dedicated to the study of star formation through direct measurements (1) molecular cloud composition and chemistry, (2) cooling mechanisms that facilitate collapse, (3) large-scale structure UV-illuminated surfaces. To achieve these goals, SWAS conducting pointed observations dense [n(H2) > 103 cm-3] clouds throughout our Galaxy either ground state or low-lying transition five astrophysically...
Immunotherapy that block PD-1–PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder cancers. However, these responses only occur a subset patients. We study gene expression profiles 1763 muscle-invasive cancers (MIBCs) 11,835 solid tumors from TCGA. establish an immune-based classification on basis composition microenvironment identify six distinct phenotypes. The class F was characterized by strong tertiary lymphoid structures...
•First systematic research of ChatGPT in healthcare with reliable data sources•Novel and effective perspective from digital media (i.e., 89 selected online news articles)•Summarization 26 applications, 21 opportunities, 17 challenges health age IntroductionThe emergence application generative artificial intelligence/large language models (hereafter GenAI LLMs) have the potential for significant impact on industry. However, there is currently a lack LLMs based data. This article aims to...
Objective Abdominal adipose is closely related to many endocrine and metabolic diseases. The aim of this study was analyze the distribution abdominal tissue in a healthy population northern China determined by computed tomography (CT). Methods Data for were obtained from multicenter, retrospective, cross-sectional that collected CT scans 1787 individuals 4 representative cities China. Areas visceral (VATA) subcutaneous (SATA) measuring images at level 3rd lumbar vertebra. Visceral index...
No AccessJournal of UrologyInvestigative urology1 May 2007Up-Regulation Estrogen Responsive Genes in Hypospadias: Microarray Analysis Zhong Wang, Ben Chun Liu, Gui Ting Lin, Ching-Shwun Tom F. Lue, Emily Willingham, and Laurence S. Baskin WangZhong Wang More articles by this author , LiuBen Liu LinGui Lin LinChing-Shwun LueTom Lue WillinghamEmily Willingham BaskinLaurence View All Author Informationhttps://doi.org/10.1016/j.juro.2007.01.014AboutFull TextPDF ToolsAdd to favoritesDownload...
Background: The novel coronavirus 2019 (COVID-19) pandemic and related compulsory measures have triggered a wide range of psychological issues. However, the effect COVID-19 on mental health in late-middle-aged adults remains unclear. Methods: This cross-sectional, web-based survey recruited 3,730 participants (≥ 50 years old) between February 28 March 11 2020. Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Insomnia Severity Index, Acute Stress Disorder Scale were used to...
The search for effective in-feed antibiotic alternative is growing due to the global trend reduce or ban utilization of antibiotics as growth promotors in poultry diets. This study was processed assess effect dietary refined functional carbohydrates (RFCs) replacing promoters (AGP) on performance, intestinal morphologic structure and microbiota, well immune function barrier broilers reared a commercial farm. Trials contained 3 treatments with 4 replicate broiler houses, about 25,000 birds...
Abstract As one of the most vital methods in drug development, repositioning emphasizes further analysis and research approved drugs based on existing large amount clinical experimental data to identify new indications drugs. However, didn’t achieve enough prediction performance, these do not consider effectiveness information drugs, which make it difficult obtain reliable valuable results. In this study, we proposed a framework termed DRONet, full use comparative relationships (ECR) among...
Sucrose phosphate synthase (SPS) is an important enzyme in the sucrose synthesis of plants, governing accumulation and distribution photosynthetic assimilates, which essential for plant growth stress tolerance. This study successfully identified eight NtSPS genes within genome cultivated tobacco. Phylogenetic analysis revealed that these are categorized into three subfamilies, a classification supported by examination their gene structures conserved domains. The promoters NtSPSs contained...
The West Nile virus (WNV) is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on novel gene expression analysis, RNA-Seq, to give global picture differential by primary human macrophages 10 healthy donors infected in vitro with WNV. From total 28 million reads per sample, identified 1,514 transcripts that were differentially expressed after infection. Both predicted changes detected, as isoforms, while...
One of the most active fields in cancer immunotherapy is study bispecific antibodies, which engage immune cells to kill cells. However, a variety issues are associated with current antibody formats. In this study, we present novel antibody, BiSS (Bispecific Single domain, domain antibodies), was constructed by linking 2 single anti-CEA and anti-CD16, tandem. Unlike other can be expressed purified from E.coli large quantities. By recruiting natural killer (NK cells) CEA-positive cells, led...
Phenotypic plasticity, that is multiple phenotypes produced by a single genotype in response to environmental change, has been thought play an important role evolution and speciation. Historically, knowledge about phenotypic plasticity resulted from the analysis of static traits measured at time point. New insight into adaptive nature can be gained understanding how organisms alter their developmental processes range environments. Recent advances statistical modeling functional data genetics...
Analysis of the diverse interactions multiple signaling pathways is an emerging challenge in era networking pharmacology. To reveal imbalanced and pharmacological mechanisms involved ischemic process, we designed systemic experiments from top-down to bottom-up for investigating variations mouse hippocampal cells. A total 711 focal cerebral ischemia-reperfused animals (504 mice 207 rats), induced by occlusion middle artery, were obtained conduct 4 experiments. The used analyze effects four...
Abstract In recent years, more and studies focus on the roles of genes or miRNAs in stroke. However, molecular mechanism connecting their targetgenes remains unclear. The aim this study was to determine differential regulation correlations between human Stroke-related were obtained from Human MicroRNA Disease Database (HMDD) generated three independent sources. Kappa score used create network functional modules. A total 11 stroke-related identified HMDD 441 overlapping extracted databases....
Accurate evaluation of morphological and physiological traits is critical for selection wheat (Triticum aestivum L.) cultivars exhibiting high yield, which stable over different growing conditions. In order to use index based on grain quality drought tolerance in wheat, a set 145 CIMMYT Wheat Physiological Germplasm Screening Nursery lines seven local spring varieties were phenotyped evaluated yield under two irrigation regimes during the 2011 2012 seasons Xinjiang, China. The results showed...