A5114137583- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Associations and Epidemiology
- Lipid metabolism and disorders
- Advanced Neuroimaging Techniques and Applications
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Herpesvirus Infections and Treatments
- Chronic Myeloid Leukemia Treatments
- Nuclear Receptors and Signaling
- Diet, Metabolism, and Disease
- Genetics and Neurodevelopmental Disorders
- Erythropoietin and Anemia Treatment
- Amoebic Infections and Treatments
- Dermatology and Skin Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Remote Sensing and Land Use
- Hemoglobinopathies and Related Disorders
- Histone Deacetylase Inhibitors Research
- Endoplasmic Reticulum Stress and Disease
- Microbial Natural Products and Biosynthesis
- Abdominal Trauma and Injuries
- Genetic Neurodegenerative Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Chengdu University of Traditional Chinese Medicine
2025
Ruijin Hospital
2022-2024
Shanghai Jiao Tong University
2023-2024
Center for Excellence in Brain Science and Intelligence Technology
2022-2024
Jiangsu Province Hospital
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Guangxi Medical University
2024
Anhui Polytechnic University
2024
ABSTRACT This study aims to elucidate the potential genetic commonalities between metabolic syndrome (MetS) and rheumatic diseases through a disease interactome network, according publicly available large‐scale genome‐wide association studies (GWAS). The analysis included linkage disequilibrium score regression analysis, cross trait meta‐analysis colocalisation identify common overlap. Using modular partitioning, network‐based two proteins in protein–protein interaction set was divided...
Abstract Background Inflammations play crucial role in the pathogenesis of Parkinson’s disease (PD), however, their possible value diagnosis or tracking progress PD is still limited, because discordant results literature and a lack information regarding its reproducibility. Thus, overall longitudinal cross-sectional studies are needed. This multicentre study was designed to investigate association between multiple peripheral immune biomarkers development progression PD. Methods study. First,...
Abstract Nervous system diseases are among the most common globally, posing a severe threat to patients' quality of life and placing considerable burden on families society. With improvements in miniaturization, intelligence, safety biosensors, combination machinery organisms is becoming increasingly common. In neuroscience research, biosensors different macroscopic dimensions have been uniquely utilized harness their relevant properties. One‐dimensional (1D) can achieve situ real‐time...
Motor neurons are highly polarized, and their axons extend over great distances to form connections with myofibers via neuromuscular junctions (NMJs). Local translation at the NMJs in vivo has not been identified. Here, we utilized motor neuron-labeled RiboTag mice TRAP (translating ribosome affinity purification) technique spatiotemporally profile translatome NMJs. We found that mRNAs associated glucose catabolism, synaptic connection, protein homeostasis enriched presynapses. synapse...
Gout is an inflammatory arthritis resulting from urate crystal deposition, now recognized as part of metabolic syndrome. Hyperuricemia, a hallmark gout, associated with various health complications, including liver cancer. Observational studies indicate link between gout and increased cancer incidence. However, the causal relationship hepatocellular carcinoma remains uncertain. This study utilizes Mendelian randomization (MR) to explore this connection, minimizing confounding factors...
ABSTRACT In patients with Parkinson’s disease (PD), cognitive impairment is common and substantially exacerbates severity. The objective of this study to investigate whether decline affects severity structural network disruption contributes in PD patients. (n = 146) receiving functional magnetic resonance imaging from Progression Markers Initiative (PPMI) database were included. Based on the scores Symbol Digit Modalities Test (SDMT), classified into lower quartile group (SDMT score rank:...
Abstract Background A multitude of genetic variants confer a risk Parkinson’s disease (PD), however, whether these affected the motor symptoms PD patients remain largely elusive. The objective this study is to investigate effects BCKDK rs14235 (G > A), variant associated with risk, on manifestations and brain networks patients. Methods (n = 146) receiving magnetic resonance imaging from Progression Markers Initiative (PPMI) database were investigated. systematically evaluated. Results...
To the Editor: Parkinson's disease (PD) is one of most common neurodegenerative movement disorders.[1] The severity PD-related motor symptoms usually semiquantitatively ("normal", "slight", "mild", "moderate", and "severe") evaluated by expert physicians according to Movement Disorder Society-sponsored revision Unified Disease Rating Scale Part III (MDS-UPDRS III).[2] However, MDS-UPDRS semiquantitative subjective, which might mask mild treatment effects or even provide false-positive...
Abstract At present, the adjustment of power flow non-convergence in large grid is still mostly based on manual trial and error, which relies heavily expert experience inefficient. Therefore, an intelligent analysis method index system image feature fusion proposed. Firstly, constructed according to actual demand, can provide data support for following convergence judgment problems. Secondly, taking into account constraints similarity ternary loss, information used guide output...
Background Brain network dysfunction has been characterized by resting-state electroencephalography (EEG) and magnetic resonance imaging (MRI) in the prodromal stage. This study aimed to identify multi-modal electrophysiological neuroimaging biomarkers for differential diagnosis synucleinopathies phenoconversion isolated rapid eye movement sleep behavior disorder (iRBD). Methods We enrolled 35 patients with multiple system atrophy (MSA), 32 Parkinson's disease (PD), 30 iRBD matched healthy...
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<title>Abstract</title> <bold>Background:</bold> Accumulating studies have suggested associations between peripheral inflammation and neurodegenerative disorders, including Parkinson’s disease (PD). <bold>Objective: </bold>To evaluate the causal 91 plasma inflammatory proteins 4 disorders. <bold>Methods: </bold>Two-sample Mendelian randomization were performed using summary statistics extracted from genome-wide association of <bold>Results: </bold>Genetically proxied tumor necrosis factor...
Knowledge distillation (KD) enhances the performance of a student network by allowing it to learn knowledge transferred from teacher incrementally. Existing methods dynamically adjust temperature enable adapt varying learning difficulties at different stages KD. KD is continuous process, but when adjusting temperature, these consider only immediate benefits operation in current phase and fail take into account its future returns. To address this issue, we formulate adjustment as sequential...
Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph(+)B-ALL) is a hematological malignancy with poor prognosis. Epigenetic abnormalities, especially abnormal histone acetylation and microRNAs (miRNAs) dysregulation, are group of epigenetic patterns that contribute to progression. However, their regulatory mechanisms in Ph(+)B-ALL have not been fully elucidated. In this study, we identified miR-183-5p significantly downregulated associated Moreover, found the BCR-ABL...
Numerous lines of evidence suggest that neuropeptide Y (NPY) is critically involved in the modulation neuropathic pain. Postherpetic neuralgia (PHN) characterized by prolonged duration, severe pain, and significant treatment resistance, substantially impairing patients' quality life. This study aims to evaluate potential plasma NPY levels patients with PHN as a predictive biomarker for development this condition.