A5100775823- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- Pharmacogenetics and Drug Metabolism
- Invertebrate Immune Response Mechanisms
- Bacteriophages and microbial interactions
- Vitamin K Research Studies
- Advanced oxidation water treatment
- Aquaculture Nutrition and Growth
- Fungal Biology and Applications
- RNA and protein synthesis mechanisms
- Steroid Chemistry and Biochemistry
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Manufacturing Process and Optimization
- Advanced Photocatalysis Techniques
- Robot Manipulation and Learning
- Microbial Metabolism and Applications
- Probiotics and Fermented Foods
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
Nanjing Agricultural University
2025
Anhui Polytechnic University
2022-2024
Jiangnan University
2016-2024
Jiangsu Industry Technology Research Institute
2024
Minzu University of China
2022-2023
Hebei University of Science and Technology
2022
Chinese Academy of Sciences
2022
Northeast Forestry University
2019
State Key Laboratory of Food Science and Technology
2016
Wuxi Institute of Technology
2016
A comparative study of the anti-diabetic effects exerted by live and dead multi-strain probiotics in type 2 diabetes model mice.
To improve the screening efficiency of high-yield neomycin sulfate (NM) Streptomyces fradiae strains after mutagenesis, a high-throughput method using streptomycin resistance prescreening (8 μg/mL) and 24-deep well plates/microplate reader (trypan blue spectrophotometry) rescreening strategy was developed. Using this approach, we identified high-producing NM mutant strain, Sf6-2, via six rounds atmospheric room temperature plasma (ARTP) mutagenesis screening. The displayed potency 7780 ± 110...
Land degradation and agricultural pollution have been of great concern around the world in recent years, especially developing countries. It is necessary to expand some eco-friendly soil-management practices address serious environmental issues. Using data from 646 small-farm households Shandong, China, perceptions land degradation, adoption attitudes final decisions are all evaluated, factors affecting farmers' estimated by applying a logit model. The results show that perception levels...
<italic>Lactobacillus plantarum</italic> X1 is of potential beneficial utility to counter diabetes <italic>via</italic> five pathways, which including dyslipidemia, oxidative stress, α-glucosidase, gut microbiota, and inflammatory.
Bacillus cereus (B. cereus), a prevalent foodborne pathogen, constitutes substantial risk to food safety due its pronounced resilience under adverse environmental conditions such as elevated temperatures and ultraviolet radiation. This can be attributed capacity for biofilm synthesis sustained high viability. Our research aimed elucidate the mechanisms governing biosynthesis in B. cereus. To this end, we constructed 5088-mutant library of strain BC1 utilizing transposon TnYLB-1. Systematic...
High spontaneous mutation rate is crucial for obtaining ideal phenotype and exploring the relationship between genes phenotype. How to break genetic stability of organisms increase frequency has become a research hotspot. Here, we present practical controllable evolutionary tool (oMut-Cgts) based on dual level modification engineering Corynebacterium glutamicum. Firstly, transcription replication levels RNA polymerase α subunit DNA helicase Cgl0854 as 'dock' cytidine deaminase (pmCDA1)...
Lactoferrin is an iron-binding glycoprotein with antibacterial, antitumor, and immunomodulatory functions derived from milk mucosal secretions. used in various products, such as infant formula powder, nutritional supplements, cosmetics. Researchers have developed new technologies to produce lactoferrin because there are limitations the separation purification of that cannot compensate for market demand. Therefore, synthetic systems been development genetic engineering, structure expressed...
A new cellular model was established for screening the probiotics with direct effects on tight junction restoration efficiently.
Steroids, the second largest drug category ranked after antibiotics, find widespread use in treatments for reproductive health, endocrine regulation, and inflammation. Advances steroidal chemistry to date have led of sterols as starting substances development environmentally friendly biotechnologies steroid production, including biocatalysis, microbial transformations, biosynthesis using engineered micro-organisms. In this review, we synthesize some recent advancements biocatalysis...
Indigoidine, as a kind of natural blue pigment, is widely used in textiles, food, and pharmaceuticals mainly synthesized from l-glutamine via condensation reaction by indigoidine synthetases, most which originates Streptomyces species. However, due to the complex metabolic switches Streptomyces, researchers choose overexpress synthetases heterologous host achieve high-level production indigoidine. Considering advantages low-cost culture medium simple conditions during large-scale here, an...
The aminoglycoside antibiotic neomycin has broad antibacterial properties and is widely used in medicine agriculture. With the discovery of neomycin’s potential applications treating tumors SARS-CoV-2, it necessary to accelerate biosynthesis neomycin. In present study, we investigated effects various inorganic salts on B (the main active neomycin) Streptomyces fradiae SF-2. We found that 60 mM (NH4)2SO4 could promote cell growth most effectively. Further comparative transcriptomic analyses...