A5035499526- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Mechanical Circulatory Support Devices
- Anesthesia and Neurotoxicity Research
- Hemoglobin structure and function
- Thyroid Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Acute Kidney Injury Research
- Blood transfusion and management
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Trauma Management and Diagnosis
- Anesthesia and Pain Management
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Sedative Agents
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traumatic Brain Injury and Neurovascular Disturbances
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Cardiac tumors and thrombi
- Metabolomics and Mass Spectrometry Studies
Sichuan University
2015-2025
West China Hospital of Sichuan University
2015-2025
University of Notre Dame
2024-2025
West China Medical Center of Sichuan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Nanjing Agricultural University
2025
Suzhou Traditional Chinese Medicine Hospital
2024
Huazhong Agricultural University
2010-2019
Hebei Provincial Center for Disease Control and Prevention
2002
Septic cardiomyopathy is a life-threatening complication of severe sepsis and septic shock. Oxidative stress mitochondrial dysfunction have been identified as significant abnormalities in cardiomyopathy. However, specific treatments are rare. This study aims to investigate the impact β-hydroxybutyrate (β-OHB) on explore underlying mechanism(s). We found that pretreatment D-β-hydroxybutyrate-(R)-1,3 butanediol monoester (ketone ester, 3 mg/g body weight, once daily) by gavage for three days...
Emerging evidence suggests that Toll-like receptors (TLRs) ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion (I/R) injury. As ligand TLR3, polyinosinic-polycytidylic acid (poly(I:C)), synthetic double-stranded RNA, whether its preconditioning can exhibit cardioprotective phenotype remains unknown. Here, we report protective effect poly(I:C) acute I/R injury by activating TLR3/PI3K/Akt signaling pathway. Poly(I:C) leads to significant reduction...
Abstract Background Primary malignant cardiac tumors are rare in clinic, and surgical resection under cardiopulmonary bypass (CPB) remains the main treatment. The non-physiological perfusion process of CPB leads to contact activation, resulting coagulopathy systemic inflammatory response syndrome (SIRS) common complications. However, it is difficult predict impact foreign tumor fragments on this pathophysiological once they enter bloodstream, making phenomenon more complex challenging. Case...
The aberrant vascular architecture in solid tumors is the key limiting factor known to ameliorate hypoxia and increase circulating anticancer drugs, thus resulting resistance radiotherapy chemotherapy tumor treatment. Previous experiments have reported hemoglobin-based oxygen carriers (HBOCs) that are effective improve oxygenation, thereby serving as potential agents target-oriented hypoxic tumor. Herein, we draw hypothesis HBOCs combined with an drug may bioavailability retention turn...
ABSTRACT Niemann‐Pick disease, type C1 (NPC1) is an inborn error of intracellular cholesterol transport. Impaired function NPC1 leads to endolysosomal accumulation unesterified cholesterol, which results in progressive neurodegeneration. Although the age onset variable, classical a pediatric disease. Identification biomarkers that correlate with clinical phenotype and respond therapeutic interventions will be essential for developing effective interventions. Aβ peptides Tau protein are...
Chemerin is a novel adipokine which abundant in adipose tissue to promote adipocyte differentiation and with significant relativity BMI insulin sensitivity. We report here the molecular characterization of porcine chemerin its receptors ChemR23 GPR1, as well their transcriptional regulation during lipogenesis. was mainly expressed liver, intestine, kidney tissue, consistent expression pattern but not ChemR23, predominantly present spleen temperately tissue. further investigated...
Background: Extracorporeal membrane oxygenation (ECMO) is increasingly used in patients undergoing complex thoracic surgical procedures. However, studies reporting the clinical outcomes of these are limited to case reports, without real consensus. Our aim was evaluate perioperative use ECMO as respiratory and/or circulatory support surgery: indications, benefits, and management. Methods: Between May 2013 December 2018, we reviewed data 15 (11 males 4 females; mean age: 47 years old; range,...
<h3>Objective</h3> This study was conducted to determine whether the administration of intralipid just before aortic cross-unclamping would reduce myocardial injury in patients undergoing valve replacement surgery. <h3>Methods</h3> Seventy-three adult patients, scheduled for elective or mitral surgery without significant coronary stenosis (>70%), were randomly assigned postconditioning (ILPC) group (n=37) control (n=36): ILPC received an intravenous infusion 20% (2 mL/kg) 10 min...
Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in up to 40%~60% of paediatric patients and increases postoperative morbidity mortality. A goal-directed perfusion (GDP) strategy aimed at maintaining indexed oxygen delivery (DO2i) above the critical threshold (reported be 260~300 mL/min/m2 adults) during cardiopulmonary bypass (CPB), is effective reducing incidence CS-AKI. However, no clear standards DO2i exist. Our prior prospective cohort study exploring CPB has found nadir...