A5081121607- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Anomalies and Treatments
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Circular RNAs in diseases
- Cardiovascular and exercise physiology
- Liver Disease and Transplantation
- Cardiovascular Issues in Pregnancy
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Heart Disease Studies
- Cardiovascular and Diving-Related Complications
- Cardiovascular Effects of Exercise
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
Shanghai Pulmonary Hospital
2016-2025
Tongji University
2016-2025
Fu Wai Hospital
2014-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Creative Commons
2017
Abstract Background The coronavirus disease 2019 (COVID‐19) is a newly recognized illness that has spread rapidly all over the world. More and more reports highlight risk of venous thromboembolism (VTE) in COVID‐19. Our study aims to identify in‐hospital VTE bleeding COVID‐19 patients. Methods We retrospectively studied 138 consecutively enrolled patients with identified by Padua Prediction Score Improve bleed assessment model. clinical data features were analyzed Results findings 23 (16.7%)...
<h3>Background</h3> Although sildenafil has been shown to be safe and effective in idiopathic pulmonary arterial hypertension (PAH) PAH related connective tissue disease, its effects Eisenmenger syndrome are less clear. <h3>Objective</h3> To investigate whether long-term treatment (12 months) with the phosphodiesterase type 5 inhibitor improves clinical haemodynamic parameters patients syndrome. <h3>Design</h3> Prospective, open-label, multicentre study. <h3>Setting</h3> Four centres China....
Abstract Background The coronavirus disease 2019 (COVID-19) is a newly recognized illness that has spread rapidly all over the world. Severe hypoxemic respiratory failure from COVID-19 will bring high risk of venous thromboembolism (VTE). Our study aims to identify in-hospital VTE and bleeding in patients. Methods We retrospectively studied 138 consecutively enrolled patients with identified by Padua Prediction Score Improve bleed assessment model. clinical data features were analyzed...
Idiopathic pulmonary arterial hypertension (IPAH) is a fatal disease with high heritability; however, the bone morphogenetic protein receptor 2 (BMPR2) gene only accounts for 17% of IPAH. The genetic basis IPAH needs further investigation.To identify novel susceptibility genes other than BMPR2.This 2-stage, case-control association study enrolled 230 patients from referral centers in China. Eligible had no BMPR2 variants and were compared 968 healthy control participants. Data collected...
Studies have shown that vasodilators such as iloprost can be useful for treating pulmonary hypertension (PH). However, in patients with COPD, may inhibit hypoxic vasoconstriction and impair gas exchange. The efficacy safety of inhalation was assessed 67 PH associated COPD (COPD-PH), diagnosed by right heart catheterization. Of these, 37 had severe (mean arterial pressure [mPAP] >35 mmHg or mPAP 25-35 low cardiac index [<2.0 L⋅min-1⋅m-2]). All received a single 20 µg dose via nebulizer (4.4...
This study intended to search for potential correlations between anaemia in patients with severe chronic obstructive pulmonary disease (COPD; GOLD stage III) and function at rest, exercise capacity as well ventilatory efficiency, using test (PFT) cardiopulmonary testing (CPET).The was undertaken Shanghai Pulmonary Hospital, a tertiary-level centre affiliated Tongji University. It caters large population base within referrals from centres other cities well.157 Chinese stable COPD were divided...
Intact nitric oxide (NO) signalling is critical to maintaining appropriate pulmonary vascular tone. NO bioavailability reduced in patients with arterial hypertension. This study aimed examine the impact of plasma metabolites (NOx) relative haemodynamic dysfunction and mortality idiopathic hypertension (IPAH). A total 104 consecutive adult IPAH who had undergone genetic counselling when first diagnosed were enrolled this prospective study. The median concentration NOx (μmol·L −1 ) was...
This study aimed to evaluate the effectiveness and safety of an oral sequential triple combination therapy with selexipag after dual endothelin receptor antagonist (ERA) phosphodiesterase-5 inhibitor (PDE5I)/riociguat in pulmonary arterial hypertension (PAH) patients. A total 192 PAH patients from 10 centers had received being on dual-combination ERA PDE5i/riociguat for a minimum 3 months. Clinical data were collected at baseline 6 months treatment. The analyzed event-free survival all-cause...
Abstract Background and Aims This study aimed to evaluate the hemodynamic alterations right heart remodeling dynamics in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) undergoing treatment balloon angioplasty (BPA). Methods retrospective cohort involved a of 31 confirmed diagnosis CTEPH. Comprehensive clinical evaluations were systematically performed before BPA, at 3 6 months following procedure. Results Significant progress was evidenced by uplift percentage...