A5047352852- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Ginseng Biological Effects and Applications
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Biochemical effects in animals
- Neurological and metabolic disorders
- Medicinal Plants and Bioactive Compounds
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- RNA modifications and cancer
- RNA Research and Splicing
- Cardiovascular Disease and Adiposity
- Restless Legs Syndrome Research
- Advanced Technologies in Various Fields
Taizhou Central Hospital
2014-2025
Taizhou University
2019-2024
The purpose of the present study was to effects resveratrol on cognitive function in rats with vascular dementia and investigate molecular mechanisms its neuroprotective effects. Forty‑five SD were randomly divided into 3 groups: control group (Con group, n=15), model (VD n=15) resveratrol‑treated VD (Res n=15). (the Res group) generated by bilateral common carotid artery occlusion. received daily treatment intraperitoneally for 4 weeks. Cognitive tested using Morris water maze test. levels...
The effects and risks of the use intravenous thrombolysis between 4.5 24 hours after onset a posterior circulation ischemic stroke are not well studied. In trial conducted in China, we randomly assigned patients with stroke, without extensive early hypodensity on computed tomography no planned thrombectomy, to receive alteplase (0.9 mg per kilogram body weight; maximum dose, 90 mg) or standard medical treatment symptoms. primary outcome was functional independence (defined as score 0 2...
Dysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the role circHIVP2 in Parkinson's disease (PD) and its molecular mechanism is not well understood.
Parkinson's disease (PD) is characterized by a prodromal phase preceding the onset of classic motor symptoms. The duration and clinical manifestations PD vary widely, indicating underlying heterogeneity within this stage. This discrepancy prompts question whether specific factors contribute to divergent rates progression in PD.
Atherosclerosis (AS), as a complex chronic inflammatory disease, is 1 of the main causes cardiovascular and cerebrovascular diseases. This study aimed to confirm direct interaction between miR-146a-3p NF-κB, explore role miR-146a-3p/NF-κB in regulation inflammation AS.
Background The importance of ferroptosis and the immune system has been mentioned in pathogenesis α-synucleinopathy. α-synuclein-immunoreactive inclusions that primarily affect oligodendrocytes are hallmark multiple atrophy (MSA). Limited evidence implicates iron responses involved MSA, which is associated with neurodegeneration α-synuclein aggregation. Methods RNA sequencing data were collected from Gene Expression Omnibus database. MSA-C-related module genes identified through weighted...
Current evidence on management of impulse control disorders (ICDs) in Parkinson's disease (PD) remains scarce, and exploring modifiable risk factors is crucial.We evaluated the profiles ICDs PD patients aimed to determine associations between ICDs, metabolic syndrome components other clinical features.We enrolled diagnosed with this study conducted comprehensive assessments.We recruited 39 66 without ICDs. Out 19 (48.7%) had one disorder, while 20 (51.3%) two or more. The most commonly...
To investigate the association between thromboxane A2 receptor (TXA2R) gene promoter rs2271875, rs768963 polymorphism and acute cerebral infarction in Chinese Han population.A prospective study was conducted. From October 2009 to May 2013, 223 patients with (cerebral group) 142 cohorts normal physical examination results (control from Taizhou City Central Hospital Zhejiang Province were enrolled. Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C) low (LDL-C)...
To explore the mechanism of gypenoside XVII against cerebral ischemia/reperfusion (I/R) through nuclear factor erythroid 2-related 2/antioxidant responsive element (Nrf2/ARE) signaling pathway.Forty SPF Sprague Dawley (SD) rats were randomly divided into sham operated group, I/R model 25, 50 and 100 mg/kg groups (n = 8). Gypenoside administered or (0.01 mL/g) by intragastric administration for 14 days; other two received same dose saline. Rat was established modified line bolt method; in...
Perivascular adipose tissue plays roles in vascular inflammation and atherosclerosis. The present study aimed to evaluate the association between pericarotid fat density (PFD) circulatory inflammatory indicators, internal carotid artery (ICA) stenosis, vulnerable plaques. We retrospectively screened 498 consecutive patients who underwent both computed tomography angiography of neck January 2017 December 2020. PFD, ICA plaques were analyzed using established approaches. Laboratory data...
Impulse control disorders (ICDs) are an increasingly recognized complication in Parkinson disease (PD). The pathogenesis of ICDs is currently unclear. Few genetic studies have been conducted this area.
Objective To study the application of precise management on controlling door-to-needle (DTN) time in patients with acute ischemic stroke (AIS). Methods A consecutive two-way cohort was conducted. The AIS treated recombinant tissue-type plasminogen activator (rt-PA) for thrombolytic therapy admitted to Department Neurology Taizhou Central Hospital Zhejiang Province were enrolled. Conventional thrombolysis process (conventional control group, n = 22) from January 2013 March 2014...