A5061037351- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Ion Transport and Channel Regulation
- Transplantation: Methods and Outcomes
- Cardiac Fibrosis and Remodeling
- Hybrid Renewable Energy Systems
- Cancer-related gene regulation
- Tea Polyphenols and Effects
- Renal Diseases and Glomerulopathies
- Poisoning and overdose treatments
- Plant and Fungal Interactions Research
- Traditional Chinese Medicine Analysis
- Liver physiology and pathology
- Chronic Kidney Disease and Diabetes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Eicosanoids and Hypertension Pharmacology
Daping Hospital
1999-2025
Army Medical University
1999-2025
Kunming Medical University
2023-2025
First Affiliated Hospital of Kunming Medical University
2023-2025
Fujian Medical University
2022-2024
Union Hospital
2022-2024
University of Chinese Academy of Sciences
2021-2024
Cardiovascular Research Center
2023
Chinese Academy of Sciences
2023
First People's Hospital of Chongqing
2022
Vascular smooth muscle cell (VSMC) phenotype switching is a pathological hallmark in various cardiovascular diseases. N4-acetylcytidine (ac4C) catalyzed by N-acetyltransferase 10 (NAT10) well conserved the enzymatic modification of ribonucleic acid (RNA). NAT10-mediated ac4C acetylation involved physiological and processes, including cardiac remodelling. However, biological functions underlying regulatory mechanisms mRNA modifications vascular diseases remain elusive.
Pulmonary ischemia/reperfusion (IR) injury is the leading cause of acute lung injury, which mainly attributed to reactive oxygen species (ROS) induced cell injuries and apoptosis. Since rosmarinic acid (RA) has been identified as an antioxidant natural ester, this compound might protect against pulmonary IR injury. In study, mice were given RA daily (50, 75, or 100 mg/kg) by gavage for 7 days before We found that hypoxemia, edema, serum inflammation cytokines aggravated in pretreatment (75...
Abstract Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoisobutyric acid (L-BAIBA), metabolite of BCAA, has multi-organ protective effects, but whether it protects lung unclear. Methods To assess the effect L-BAIBA an animal model was clamping hilum left...
Abstract Long noncoding RNAs (lncRNAs) are >200 nt RNA transcripts without protein-coding potential. LncRNAs can be categorized into intergenic, intronic, bidirectional, sense, and antisense lncRNAs based on the genomic localization to nearby genes. The current CRISPR-based lncRNA knockout strategy works efficiently for distant from gene, whereas it causes perturbance inevitably due technical limitations. In this study, we introduce a novel strategy, BESST, by deleting DNA fragment...
The formation of new and functional cardiomyocytes requires a 3-step process: dedifferentiation, proliferation, redifferentiation, but the critical genes required for efficient redifferentiation remain unknown. In our study, circular trajectory using single-nucleus RNA sequencing pericentriolar material 1 positive (PCM1+) cardiomyocyte nuclei from hearts 3 days after surgery-induced myocardial infarction (MI) on postnatal Day was reconstructed demonstrated that actin remodeling contributed...
Nonalcoholic fatty liver disease (NAFLD) is an emerging driver of cardiac arrhythmias. However, the relationship between NAFLD and malignant arrhythmia in non-ST-segment elevation myocardial infarction (NSTEMI) patients still unclear.In this study, 358 NSTEMI inpatients were enrolled. They all received 24-hour Holter monitoring after percutaneous coronary intervention. All divided into two groups: non-NAFLD group (236 cases, 65.9%) (122 34.1%). Compared with group, had a significantly higher...
Exercise has been recommended as a nonpharmaceutical therapy to treat insulin resistance (IR). Previous studies showed that dopamine D1-like receptor agonists, such fenoldopam, could improve peripheral sensitivity, while antipsychotics, which are antagonists, increased susceptibility Type 2 diabetes mellitus (T2DM). Meanwhile, exercise proved stimulate receptors. However, whether the D1 (D1R) is involved in exercise-mediated amelioration of IR remains unclear. We found antagonist, SCH23390,...
Hypertension is a leading cause of end-stage renal disease (ESRD), but currently, those at risk are poorly identified.To develop and validate prediction model for the development hypertensive nephropathy (HN).Individual data cohorts patients from Kailuan, China served to derive multivariable HN 12, 656 individuals enrolled January 2006 August 2007, with median follow-up 6.5 years. The developed was subsequently tested in both derivation external validation cohorts.Demographics, physical...
Abstract Background: Elevated lipoprotein(a) (Lp[a]) is a risk factor for first atherosclerotic thrombosis events, but the role of elevated Lp(a) in secondary prevention controversial. This study aimed to retrospectively investigate influence levels on prognosis patients with coronary artery disease. Methods: The team collected and compared clinical information hospitalized during percutaneous intervention (PCI). used multivariate logistic regression model evaluate relationships between...
Abstract Background To investigate the relationship between salt taste threshold and hypertensive nephropathy in patients with essential hypertension. Methods A cross-sectional study was conducted 346 Daping Hospital from 2017 to 2019. Among them 94 were 252 without renal damage served as controls. The of measured by taking different concentrations NaCl solution. difference 2 groups compared, correlation analyzed. Receiver operating characteristic (ROC) curve used analyze value predict...
Objective To apply the ‘organ-systems-based cmriculum' (OSBC) medical teaching method in clinical novitiate cmriculum,to conduct an OSBC oriented curriculum reform and to observe its effectiveness.Methods Daping Hospital of Third Military Medical University implemented cmriculum on undergraduates class 2010 during academic year 2012-2013.The traditional departments based disciplines were dissolved new groups built up organ/systems.The curriculums integrated jointed was carried out.The...
G protein-coupled receptor kinase 4 (GRK4) gene variants or increased GRK4 expression, via impairment of renal dopamine and enhancement renin angiotensin system function, impairs sodium excretion, resulting in retention an increase blood pressure. Increased aortic stiffness, a risk factor cardiovascular disease, may be related to activity the renin-angiotensin Whether not type 1 (AT R) interact aorta is known. We now report that expressed vascular smooth muscle cells (VSMCs) aorta. Exogenous...
The incidence of chronic kidney disease (CKD) has incrementally increased for decades and showed a positive correlation with pollutants, including the surging plastic pollution. Although reports suggested their adverse impact on kidney, no comprehensive study investigated effect microplastics renal function. In this study, we that oral gavage polystyrene caused functional impairment, albuminuria, elevation serum creatinine blood urea nitrogen. Microplastic exposure also hyperproliferation...
Abstract Background: Lung ischemia-reperfusion injury is a serious clinical problem and there no effective treatment. Ischemia-reperfusion (I/R) always accompanied with changed branched chain amino acid (BCAA) metabolism. Enhancing BCAA metabolism can protect against injury. We believe that this phenomenon related to bioactive molecules produced by And, L-β-aminoisobutyric (L-BAIBA) metabolite of valine, member BCAA. Methods: Adult C57BL/6 mouse were treated L-BAIBA (150mg/kg/day) in the...
Dopamine plays an important role in the regulation of blood pressure by inhibition sodium transport renal proximal tubules (RPTs) and relaxation vascular smooth muscles. The ETB receptor, like D1 D3 dopamine receptors, inhibits RPT; however, activation ETB, unlike these receptor subtypes, can directly constrict There is abundant expression receptors RPT, increase RPT cells from Wistar-Kyoto (WKY) cells. In addition, natriuretic effect agonist be blocked antagonist. Because regulate each...
Objectives: To investigate the effect of D4 dopamine receptor on Na+-K+-ATPase activity in renal proximal tubule (RPT) cells, underlying mechanism(s) is also determined this experiment. Methods: Immortalize RPT cells was used study to agonist PD168077 from Wistar-Kyoto (WKY) rats. The NO production were by nitrate reductase method. Results: inhibited Na+- K+-ATPase a concentration- and time-dependent manner WKY cells. blocked presence antagonist L745870 (10–6 mol/L) synthase inhibitor L-NAME...
Objectives: The dopaminergic and renin angiotensin systems interact to regulate blood pressure. Disruption of the D4 dopamine receptor gene in mice produces hypertension that is associated with increased renal AT1 expression. We hypothesize can inhibit expression function RPTscells from WKY rats, regulation on aberrant RPT cells SHRs. Methods: protein detected by immunoblotting. Na+-K+-ATPase activity was determined as rate inorganic phosphate released presence or absence ouabain. Results:...