A5100770543- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Retinal Imaging and Analysis
- Gestational Trophoblastic Disease Studies
- Neuroendocrine Tumor Research Advances
- Retinal Diseases and Treatments
- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Osteoarthritis Treatment and Mechanisms
- Birth, Development, and Health
- Folate and B Vitamins Research
- Glaucoma and retinal disorders
- RNA modifications and cancer
- Airway Management and Intubation Techniques
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Colorectal and Anal Carcinomas
- Anesthesia and Pain Management
- Tracheal and airway disorders
- Effects and risks of endocrine disrupting chemicals
- Photodynamic Therapy Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
Northwest University
2024-2025
Qilu Hospital of Shandong University
2022-2025
Central China Normal University
2021-2025
National Health and Family Planning Commission
2017-2025
Peking University
2013-2025
Southern Medical University
2025
Nanfang Hospital
2025
Shanghai Pesticide Research Institute
2025
First Affiliated Hospital of Fujian Medical University
2003-2024
Sun Yat-sen University
2016-2024
ObjectiveTo examine the psychological distress and associated predictor factors of 2019 corona-virus disease (COVID-19) on survivors in early convalescence Shenzhen.MethodA survey questionnaire consisting post-traumatic stress disorder self-rating scale (PTSD-SS), depression (SDS), anxiety (SAS) was presented to COVID-19 still quarantine. Scores each subscale were dependent variables Mann-Whitney test stepwise regression analysis.ResultsA total 126 subjects included study, mean scores...
Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression human chondrocytes. The aim this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p assessed mesenchymal stem cell (hMSC) model chondrogenesis, interleukin-1β (IL-1β)-treated primary chondrocytes (PHCs), non-degraded degraded cartilage. hMSCs PHCs were transfected with or its antisense...
We have developed a new web application for peptide matching using Apache Lucene-based search engine. The Peptide Match service is designed to quickly retrieve all occurrences of given query from UniProt Knowledgebase (UniProtKB) with isoforms. matched proteins are shown in summary tables rich annotations, including sequence region(s) and links corresponding number proteomic/peptide spectral databases. results grouped by taxonomy can be browsed organism, taxonomic group or tree. supports...
Abstract Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic diseases lacks effective treatment. Tamoxifen has been proven to be the first-line chemotherapy for several solid tumors in clinics, however, its therapeutic role NAFLD never elucidated before. In vitro experiments, tamoxifen protected hepatocytes against sodium palmitate-induced lipotoxicity. male and female mice fed with normal diets, continuous administration inhibited lipid accumulation liver, improved...
Objective:The aim of this study was to observe the liver function recovery COVID-19 patients after discharge.Patients and Methods: A total 253 discharged in Shenzhen city, China were selected.The clinical characteristics these assessed.A 2-month follow-up laboratory hematology test performed examine status patients' function.Results: Patients combined with diseases, especially fatty liver, are more likely progress severe condition (P<0.05).Patients those diseases have higher rates injuries...
Exposure to environmental endocrine disruptors (EDCs) may lead abnormal glucose metabolism and, potentially, gestational diabetes mellitus (GDM). We investigated the association between five endocrine-disrupting heavy metals (EDHMs), i.e., arsenic (As), cadmium (Cd), (Pb), mercury (Hg), and tin (Sn), in maternal hair risk of GDM. conducted a nested case-control study including 335 GDM cases 343 controls without based on prospective birth cohort established Beijing, China. Concentrations...
Purpose To investigate the micro-vascular changes in choroidal structures patients with pre- and early-stage clinical diabetic retinopathy (DR) using wide-field Swept-Source Optical Coherence Tomography Angiography (SS-OCTA). Method This observational cross-sectional study included 131 eyes of 68 subjects that were divided into healthy controls (group 1, n = 46), pre-DR 2, 43), DR 3, 42) cohorts. All participants underwent SS-OCTA examination inpatients department Ophthalmology...
Abstract Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining liver homeostasis and influencing the pathological processes of various diseases. However, neither LSEC-specific hallmark genes nor LSEC promoter-driven Cre mouse line has been introduced before, which largely restricts study diseases with vascular disorders. To explore genes, we compared top 50 marker between (ECs) capillary ECs identified 18 overlapping genes. After excluding globally expressed those low...
Phthalates (PAEs) and polycyclic aromatic hydrocarbons (PAHs) are frequently detected in females of reproductive age. Many studies have found that environmental PAE PAH levels independent risk factors for gestational hypertension. However, exposure to both components is a more realistic scenario. To better assess the health effects PAEs PAHs pregnant women, we explored associations individual combined with This nested case-control study was component prospective cohort conducted Beijing,...
Cortisol, a steroid hormone, is secreted by the hypothalamic-pituitary-adrenal system. It well-known biomarker of psychological stress and hence known as "stress hormone." If cortisol overexpression prolonged repeated, dysfunction in regulation eventually occurs. Therefore, rapid point-of-care assay to detect needed. Salivary electrochemical analysis non-invasive method that potentially useful enabling measurement levels. In this study, multilayer films containing two-dimensional tin...
The aim of this analysis was to study the impact marital status on inflammatory breast cancer (IBC) patients, as prognostic is yet be studied in detail.Data IBC patients from 2004 2010 were sorted out database surveillance, epidemiology, and end results (SEER), overall survival (OS) rates cancer-specific (CSS) compared between a group married unmarried patients. comparison performed by Kaplan-Meier method with log-rank test, multivariate CSS OS using Cox proportional hazard model.Data 1342...
To investigate the phenotypic heterogeneity of tissue-resident synovial fibroblasts and their role in inflammatory response rheumatoid arthritis (RA). We used single-cell spatial transcriptomics to profile cells gene expressions tissues identify changes patients with osteoarthritis, RA sustained remission active state. Immunohistology, multiplex immunofluorescence flow cytometry were subsets. Deconvolution methods further validated our findings two cohorts (PEAC R4RA) treatment response....
To investigate the alterations in retinochoroidal parameters measured by optical coherence tomography (OCT) and OCT angiography (OCTA) patients with carotid artery stenosis (CAS) assess their associations digital subtraction (DSA) data. This study enrolled diagnosed CAS age-matched healthy controls. Both groups underwent OCTA examinations. DSA assessment of were performed only group. The evaluated various from OCTA, including linear vessel density (LVD), foveal avascular zone (FAZ),...
Geniposide, as a type of iridoid glycoside, has antioxidative capacity. However, the mechanism underlying effect geniposide in cadmium (Cd)‑induced osteoblast injury remains only partly elucidated. In present study, Cell Counting Kit‑8 (CCK‑8) was used to determine MC‑3T3‑E1 cell viability. Flow cytometry rate apoptosis and levels reactive oxygen species (ROS). Oxidative stress‑related factors were assessed using enzyme‑linked immunosorbent method (ELISA). Quantitative real‑time polymerase...
In this study, erianin was found to reduce the viability of cancer cells, inhibit their proliferation and migration, induce G2/M phase arrest, enhance cell apoptosis, promote an increase in levels intracellular reactive oxygen species a decrease mitochondrial membrane potential, regulate expression anti- pro-apoptosis-related proteins HepG2 SMMC-7721 cells. Erianin inhibited tumor growth HepG2- SMMC-7721-xenograft nude mouse models, reduced anti-apoptosis enhanced pro-apoptosis tissues....
The aim of the present study was to explore antitumor effects sinoporphyrin sodium (DVDMS)‑mediated photodynamic therapy (PDT) and sonodynamic (SDT) in glioma, reveal underlying mechanisms. uptake DVDMS by U‑118 MG cells detected flow cytometry (FCM). A 630‑nm semiconductor laser 1‑MHz ultrasound were used perform PDT SDT, respectively. Cell proliferation apoptosis evaluated using Counting Kit‑8 assay, FCM Hoechst 33258 staining, Western blot analysis detect protein expression...
Background This study was designed to investigate the clinicopathological characteristics, treatment and survival of patients with pulmonary large cell neuroendocrine carcinoma (LCNEC). Methods The Surveillance, Epidemiology End Results database utilized identify diagnosed LCNEC between 2004 2013. Kaplan–Meier analysis conducted determine overall (OS) cancer-specific (CSS) rate. Univariate along log-rank test, Cox proportional hazards model were employed detect independent prognostic...
Introduction: Long non-coding RNAs (lncRNAs) have obtained increasing attention due to their regulatory functions in many cancers. This work aimed investigate the functional roles of lncRNA TTN-AS1 colorectal cancer (CRC) and explore underlying mechanisms. Methods: The expression profiles miR-497 CRC tissues cell lines were determined by RT-qPCR analysis. MTT assay, transwell western blot analysis, xenograft tumors nude mice employed analyze effects on proliferation, migration, invasion,...
Abstract The overall survival rate of patients with hepatocellular carcinoma (HCC) has remained unchanged over the last several decades. Therefore, novel drugs and therapies are required for HCC treatment. Isoliquiritigenin (ISL), a natural flavonoid predominantly isolated from traditional Chinese medicine Glycyrrhizae Radix (Licorice), high anticancer potential broad application value in various cancers. Here, we aimed to investigate role ISL cell line Hep3B. Functional analysis revealed...