A5049940913- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Diet, Metabolism, and Disease
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- Bone Metabolism and Diseases
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Connective tissue disorders research
- Bone health and treatments
- RNA Research and Splicing
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Biomarkers in Disease Prognosis
- Microtubule and mitosis dynamics
- Bladder and Urothelial Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Body Composition Measurement Techniques
- Genetic factors in colorectal cancer
University of Notre Dame
2017-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2024
Beijing Jishuitan Hospital
2021
Peking University
2021
Howard Hughes Medical Institute
2013
Princeton University
2009-2013
Ruijin Hospital
2004
Significance Immune checkpoint blockade (ICB) to reinvigorate cytotoxic T lymphocytes using antibodies against CTLA4 or PD1 generates durable therapeutic responses in patients across a variety of cancer types. However, some cancers such as castration-resistant prostate (CRPC) show overwhelming resistance ICB. Here, we develop nitroproteomic approach and uncover potential mechanism for the immunotherapy where key protein cell activation, lymphocyte-specific tyrosine kinase (LCK), is nitrated...
Resistance to immune checkpoint blockade (ICB) therapy represents a formidable clinical challenge limiting the efficacy of immunotherapy. In particular, prostate cancer poses for ICB due its immunosuppressive features. A ketogenic diet (KD) has been reported enhance response in some other models. However, adverse effects associated with continuous KD were also observed, demanding better mechanistic understanding and optimized regimens using as an immunotherapy sensitizer. this study, we...
One of the most prominent features at mid-blastula transition (MBT)observed in embryos is a pause cell cycle regulated by nucleocytoplasmic (N/C) ratio. By using chromosome rearrangements to manipulate DNA content embryos, we determined that threshold for this Drosophila about 70% normally present 14. Embryos with contents around value show intermediate behaviors. Some 14, some 15,and form patches arrested different mitotic cycles. A second feature MBT massive increase zygotic transcription...
Abstract Penile squamous cell carcinoma (PSCC) accounts for over 95% of penile malignancies and causes significant mortality morbidity in developing countries. Molecular mechanisms therapies PSCC are understudied, owing to scarcity laboratory models. Herein, we describe a genetically engineered mouse model PSCC, by co-deletion Smad4 Apc the androgen-responsive epithelium penis. Mouse fosters an immunosuppressive microenvironment with myeloid-derived suppressor cells (MDSCs) as dominant...
The noninflamed microenvironment in prostate cancer represents a barrier to immunotherapy. Genetic alterations underlying cell-intrinsic oncogenic signaling are increasingly appreciated for their role shaping the immune landscape. Recently, we identified Pygopus 2 (
SMAD4 constrains progression of Pten -null prostate cancer and serves as a common downstream node transforming growth factor β (TGFβ) bone morphogenetic protein (BMP) pathways. Here, we dissected the roles TGFβ receptor II (TGFBR2) BMP (BMPR2) using model. These studies demonstrated that molecular actions TGFBR2 result in both SMAD4-dependent constraint proliferation SMAD4-independent activation apoptosis. In contrast, BMPR2 deletion extended survival relative to alone, establishing its...
To review the outcomes of surgical management in pediatric patients with extremity chondroblastoma. Especially risk factors recurrence and growth disorder. And discuss a potential method to decrease rate disorder by preventing premature physeal closure.Fifteen girls twenty-seven boys aged from two 14 years (mean, 11 years) histologically proven chondroblastoma, who presented January 2011 June 2018 at our Hospital, were retrospectively reviewed. Clinical data, radiographic images,...
Advanced prostate cancer (PCa) is overwhelmingly resistant to immune checkpoint blockade (ICB) therapy, representing a formidable clinical challenge. In this study, we developed syngeneic murine PCa model with acquired ICB resistance. Using model, synergistic efficacy was achieved by combining anti-PD1 and anti-CTLA4 antibodies histone deacetylase inhibitor (HDACi) vorinostat, cyclic ketogenic diet (CKD), or supplementation of ketone body β-hydroxybutyrate (BHB, endogenous HDACi) via...
Abstract Advanced prostate cancer displays conspicuous chromosomal instability and rampant copy number aberrations, yet the identity of functional drivers resident in many amplicons remain elusive. Here, we implemented a genomics approach to identify new oncogenes involved progression. Through integrated analyses focal large genomic transcriptomic datasets as well genes upregulated metastasis, 276 putative were enlisted into an vivo gain-of-function tumorigenesis screen. Among top positive...
Abstract The purpose of this study is to investigate strategies for enhancing immune checkpoint blockade (ICB) therapy in prostate cancer (PCa). To achieve this, we established a series ICB-resistant PCa cell lines derived from previously sensitive line, which originated murine model metastatic PCa. Notably, observed reduction major histocompatibility complex (MHC) class I protein levels the resistant sublines. Our demonstrated synergistic efficacy through combination anti-PD1 and anti-CTLA4...
Myeloid-derived suppressor cells (MDSCs) play an essential role in suppressing the antitumor activity of T lymphocytes solid tumors, thus representing attractive therapeutic target to enhance efficacy immunotherapy. However, differences protein expression between MDSCs and their physiological counterparts, particularly polymorphonuclear neutrophils (PMNs), remain inadequately characterized, making specific identification targeting difficult. PMNs PMN-MDSCs share markers such as...
<div>Abstract<p>Resistance to immune checkpoint blockade (ICB) therapy represents a formidable clinical challenge limiting the efficacy of immunotherapy. In particular, prostate cancer poses for ICB due its immunosuppressive features. A ketogenic diet (KD) has been reported enhance response in some other models. However, adverse effects associated with continuous KD were also observed, demanding better mechanistic understanding and optimized regimens using as an immunotherapy...
<div>Abstract<p>Resistance to immune checkpoint blockade (ICB) therapy represents a formidable clinical challenge limiting the efficacy of immunotherapy. In particular, prostate cancer poses for ICB due its immunosuppressive features. A ketogenic diet (KD) has been reported enhance response in some other models. However, adverse effects associated with continuous KD were also observed, demanding better mechanistic understanding and optimized regimens using as an immunotherapy...
<p>Supplementary FIgure S1, S2, S3, S4, S5, S6</p>
<p>Supplementary FIgure S1, S2, S3, S4, S5, S6</p>