A5072252967- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Nanoparticle-Based Drug Delivery
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Periodontal Regeneration and Treatments
- Systemic Lupus Erythematosus Research
- Cancer Research and Treatments
- Spine and Intervertebral Disc Pathology
- Tissue Engineering and Regenerative Medicine
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmacological Effects of Natural Compounds
- Bacterial Infections and Vaccines
- CAR-T cell therapy research
- Nerve injury and regeneration
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
Nanjing University of Posts and Telecommunications
2021-2025
Tianjin University
2024-2025
Southern Medical University
2021-2024
The Synergetic Innovation Center for Advanced Materials
2024
Soochow University
2018-2023
Sanofi (United States)
2020
Nanjing University of Chinese Medicine
2018
Xuzhou Medical College
2013-2015
Changzhi Medical College
2015
Affiliated Hospital of Xuzhou Medical College
2013-2015
Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen system based on the nanoerythrosomes derived from RBCs, inspired by splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto fusing tumor membrane-associated with nanoerythrosomes. This antigen-loaded (nano-Ag@erythrosome) elicited responses in vivo and, combination anti-programmed...
Autoimmune diseases are the third most common disease influencing quality of life many patients. Here, a programmed cell death-ligand 1 + (PD-L1) mesenchymal stem (MSC) derived extracellular vesicles (MSC-sEVs-PD-L1) using lentivirus-mediated gene transfection technology is developed for reconfiguration local immune microenvironment affected tissue in autoimmune diseases. MSC-sEVs-PD-L1 exhibits an impressive ability to regulate various activated cells immunosuppressed state vitro. More...
Abstract Microbe-based cancer immunotherapy has recently emerged as a hot topic for treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction anticancer immunity our formulations appears to inversely correlate with their size due the ability accumulate tumor-draining lymph...
Abstract Despite the remarkable progress in immune checkpoint blockade (ICB) therapy for cancer treatment, low objective response and immune‐related side effects (immune‐related adverse events, irAEs) limit further development of ICBs. To address these challenges enhance efficiency immunotherapy, emerging interest has focused on manipulating biomaterials to form innovational drug delivery systems that are necessary effectively deliver inhibitors. Such biomaterial‐based strategies can improve...
An implantable blood clot–based cancer vaccine is developed for enhanced immunotherapy.
Cancer vaccine platform has attracted great interest in the field of cancer immunotherapy. Here, 3D printed scaffolds loaded with immunoregulators are developed for enhanced The rapid manufacturing and precise molding based on printing can realize mass vaccines personalized design. Meanwhile, compared to traditional hydrogel, 3D-scaffold porous structure endows its similar functions real lymphoid organs by recruitment a number immune cells, leading formation "artificial tertiary structures,"...
Tumor hypoxia and acidity are well-known features in solid tumors that cause immunosuppression therapeutic resistance. Herein, we rationally synthesized a multifunctional fluorinated calcium carbonate (fCaCO3) nanoregulator by coating CaCO3 nanoparticles with dopamine-grafted perfluorosebacic acid (DA2-PFSEA) ferric ions utilizing their coordination interaction. After PEGylation, the obtained fCaCO3-PEG showed high loading efficacy to perfluoro-15-crown-5-ether (PFCE), type of...
<h3>Background</h3> Little research has been conducted regarding the implications of Sirt1 (a classic III HDAC) in neuropathic pain. The aim this study was to investigate variation expressions spinal and acetyl-histone H3 a rat model chronic constriction injury. <h3>Methods</h3> A pain injury (CCI) established unilateral hind limb Sprague-Dawley rats. <h3>Results</h3> Western blot analysis immunohistochemistry revealed that (silent information regulator) expression decreased, whereas...
Abstract The chronic inflammatory microenvironment is characterized by the elevated level of reactive oxygen species (ROS). Here, it hypothesized that developing an ROS‐scavenging scaffold loaded with rapamycin (Rapa@Gel) may offer a new strategy for modulating local to improve intervertebral disk tissue regeneration. therapeutic consisting ROS‐degradable hydrogel can be injected into injured degeneration site (IVD) and release therapeutics in programmed manner. ROS scavenged reduces...
The treatment of large-area bone defects still faces many difficulties and challenges. Here, we developed a blood clot delivery platform loaded with BMP-2 protein ([email protected]) for enhanced regeneration. Blood gel as natural biomaterials can be engineered from autologous blood. Once implanted into the large defect site, it used local delivery, well modulating osteoimmunology by recruiting great number macrophages regulating their polarization at different stages. Moreover, due to...
Tumor vaccines have been showing a relatively weak response rate in cancer patients, while deficiencies delivery efficiency to dendritic cells (DCs), as well DC-intrinsic immunosuppressive signals, contribute great extent. In this work, we report an implantable blood clot loaded with liposomes-protamine-hyaluronic acid nanoparticles (LPH NPs) containing vaccine (LPH-vaccine) and LPH NPs siRNA (LPH-siRNA) for synergistic DC recruitment activation. The subcutaneously implanted scaffold can...
Abstract Tumor hypoxia and acidity, two general features of solid tumors, are known to have negative effect on cancer immunotherapy by directly causing dysfunction effector immune cells promoting suppressive inside tumors. Herein, a multifunctional colloidosomal microreactor is constructed encapsulating catalase within calcium carbonate (CaCO 3 ) nanoparticle‐assembled colloidosomes (abbreviated as CaP CSs) via the classic double emulsion method. The yielded CCaP CSs exhibit well‐retained...
Lysosome targeting chimeras (LYTACs) have emerged as a powerful modality that can eliminate traditionally undruggable extracellular tumor-related pathogenic proteins, but their low bioavailability and nonspecific distribution significantly restrict efficacy in precision tumor therapy. Developing LYTAC system selectively target tissues enable modular design is crucial challenging. We here report programmable nanoplatform for tumor-specific degradation of multipathogenic proteins using an...
Abstract Radiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) known very effective radiosensitizer hypoxic tumor. NO cannot circulate in body concentration. Herein, an NIR light-responsive delivery system developed controlled precisely release to tumors during radiotherapy. Tert -Butyl nitrite, which efficient source, coupled Ag 2 S...
Immune checkpoint blockade (ICB) therapy has been considered as an effective way to boost immune cells recognize and attack tumors. However, side effects known immune-related adverse events (irAEs) should be carefully managed. Here, we engineer immunosuppressive nanoparticles by coating PD-L1 overexpressed mesenchymal stem (MSCs) plasma membrane on poly lactic-co-glycolic acid (MSC-PD-L1+ NPs) for managing reducing irAEs induced inhibitors. The can enrich at liver site after intravenous...