A5082867664- Respiratory viral infections research
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Systemic Lupus Erythematosus Research
- Tracheal and airway disorders
- Rheumatoid Arthritis Research and Therapies
- Pneumonia and Respiratory Infections
- Atherosclerosis and Cardiovascular Diseases
- Respiratory and Cough-Related Research
- Breastfeeding Practices and Influences
- Diabetes Management and Education
- Pregnancy and Medication Impact
- Viral gastroenteritis research and epidemiology
- Birth, Development, and Health
- Child and Adolescent Health
- Inhalation and Respiratory Drug Delivery
- Delphi Technique in Research
- Vitamin D Research Studies
- Gestational Diabetes Research and Management
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
- HIV Research and Treatment
Vanderbilt University Medical Center
2016-2025
Vanderbilt University
2016-2025
Cohort (United Kingdom)
2024-2025
Cancer Research And Biostatistics
2006-2018
Monash University
2017
University of Tasmania
2017
The University of Melbourne
2017
University of Tennessee Health Science Center
2015
Pulmonary and Allergy Associates
2015
Center for Environmental Health
2010-2014
The influence of a patient's quantitative skills (numeracy) on the management diabetes is only partially understood.To examine association between diabetes-related numeracy and glycemic control other measurements.Cross-sectional survey.2 primary care 2 clinics at 3 medical centers.398 adult patients with type 1 or mellitus enrolled March 2004 November 2005.Health literacy, general numeracy, assessed by using Rapid Estimate Adult Literacy in Medicine; Wide Range Achievement Test, 3rd edition;...
Abstract Objective To compare the prevalence and severity of coronary‐artery atherosclerosis in patients with early established rheumatoid arthritis (RA) controls. Methods Electron‐beam computed tomography was used to measure extent calcification 227 subjects, whom 70 had RA, 71 86 were Coronary‐artery calculated according Agatston calcium score compared controls, its relationship clinical characteristics examined. Adjusted odds ratios (ORs) obtained use proportional logistic regression...
Bronchiolitis during infancy is associated with an increased risk of childhood asthma. Whether winter viral infections cause asthma or are a manifestation predisposition to development unknown.To study the relationship virus infection and asthma.We studied over 95,000 infants born between 1995 2000 followed through 2005 who were enrolled in Tennessee Medicaid program from birth early determine whether infant peak alters developing asthma.Among 95,310 children five seasons childhood, tracked...
<b>Background:</b> The metabolic syndrome is an independent risk factor for ischaemic heart disease. Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis; however, there are no controlled studies of the in patients SLE. <b>Objective:</b> To compare prevalence SLE and controls to evaluate its relationship other cardiovascular factors inflammation. <b>Methods:</b> 102 101 were studied. was compared using National Cholesterol Education Program Adult Treatment Panel...
Urine neutrophil gelatinase-associated lipocalin (uNGAL) has shown promise as a biomarker for the early detection of acute kidney injury (AKI) in fixed models injury, but its ability to predict AKI and provide prognostic information critically ill adults is unknown. We prospectively studied heterogeneous population 451 adults, 64 (14%) 86 (19%) whom developed within 24 48 h enrollment, respectively. Median uNGAL at enrollment was higher among patients who compared with those did not (190...
Abstract Objective Insulin resistance is increased by inflammation, but the mechanisms are unclear. The present study was undertaken to test hypothesis that decreased insulin sensitivity differentially associated with mediators of inflammation studying 2 chronic inflammatory diseases different pathogenesis, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Methods We measured fasting insulin, glucose, lipid levels, erythrocyte sedimentation rate (ESR), C‐reactive protein...
Abstract Objective Rheumatoid arthritis (RA) is an inflammatory disease associated with premature atherosclerosis. We hypothesized that mediators of inflammation atherosclerosis in other populations (interleukin‐6 [IL‐6], tumor necrosis factor α [TNFα], serum amyloid A [SAA], vascular endothelial growth factor, neutrophil count, IL‐1α, E‐selectin, intercellular adhesion molecule 1 [ICAM‐1], myeloperoxidase [MPO], matrix metalloproteinase 9, and cell 1) would be increased the severity...
Abstract Objective Obesity protects against radiographic joint damage in rheumatoid arthritis (RA) through poorly defined mechanisms. Adipocytokines are produced adipose tissue and modulate inflammatory responses animal models. The purpose of this study was to examine the hypothesis that adipocytokines inflammation patients with RA. Methods We compared serum concentrations leptin, resistin, adiponectin, visfatin 167 RA 91 control subjects. independent association between body mass index...
Prospective data on viral etiology and clinical characteristics of bronchiolitis upper respiratory illness (URI) in infants are limited.This prospective cohort enrolled previously healthy term during inpatient or outpatient visits for acute URI September to May 2004 2008. Illness severity was determined using an ordinal score. Common viruses were identified by real-time reverse-transcriptase polymerase chain reaction.Of 648 infants, 67% 33% visits. Seventy percent had bronchiolitis, 3% croup...
OBJECTIVE Diabetic patients with lower literacy or numeracy skills are at greater risk for poor diabetes outcomes. This study evaluated the impact of providing literacy- and numeracy-sensitive care within an enhanced program on A1C other RESEARCH DESIGN AND METHODS In two randomized controlled trials, we enrolled 198 adult diabetic most recent ≥7.0%, referred participation in program. For 3 months, control received from existing programs, whereas intervention programs that also addressed...
Rationale: Fluoroquinolones are the most commonly prescribed antibiotic class in United States. They have potential to become first-line antituberculosis therapy, but effect of fluoroquinolone use on resistance Mycobacterium tuberculosis is not well characterized.Objectives: To determine prevalence and risk factors for fluoroquinolone-resistant a large States population.Methods: We identified all people with culture-confirmed enrolled TennCare (Medicaid) reported Tennessee Department Health...
Background and objectives: Urine IL-18 (uIL-18) has demonstrated moderate capacity to predict acute kidney injury (AKI) adverse outcomes in defined settings. Its ability AKI provide prognostic information broadly selected, critically ill adults remains unknown. Design, setting, participants, & measurements: The study prospectively evaluated the of uIL-18 measured within 24 hours intensive care unit (ICU) admission AKI, death, receipt dialysis a large mixed-adult ICU population. Results: Of...
Abstract Objective Mobile health (mHealth) interventions may improve diabetes outcomes, but require engagement. Little is known about what factors impede engagement, so the authors examined relationship between patient and engagement in an mHealth medication adherence promotion intervention for low-income adults with type 2 (T2DM). Materials Methods Eighty patients T2DM participated a 3-month called MEssaging Diabetes that leveraged mobile communications platform. Participants received daily...
Respiratory syncytial virus (RSV) and human rhinovirus (HRV) are the most common viruses associated with acute respiratory tract infections in infancy. Viral interference is important understanding viral circulation impact of vaccines.
OBJECTIVE. Our goal was to determine whether maternal asthma and smoking during pregnancy are associated with the incidence severity of clinically significant bronchiolitis in term, otherwise healthy infants without confounding factors small lung size or underlying cardiac pulmonary disease. PATIENTS AND METHODS. We conducted a population-based retrospective cohort study non–low birth weight enrolled Tennessee Medicaid Program from 1995 2003. The followed through first year life as...
OBJECTIVES. The goals were to estimate the year-round burden of health care visits attributable bronchiolitis and identify risk factors for in term healthy infants. METHODS. We conducted a population-based, retrospective cohort study 103 670 term, non–low birth weight infants enrolled Tennessee Medicaid 1995–2003. monitored through first year life. Risk during infancy rates inpatient, emergency department, outpatient period calculated by using claims data. RESULTS. Over 9 years, 238 per 1000...