A5079396982- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- HIV, Drug Use, Sexual Risk
- Data-Driven Disease Surveillance
- Bacillus and Francisella bacterial research
- Infection Control and Ventilation
- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- RNA modifications and cancer
- Poxvirus research and outbreaks
- COVID-19 and healthcare impacts
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Occupational Health and Safety Research
- Obesity, Physical Activity, Diet
- Animal Disease Management and Epidemiology
- Sex work and related issues
- COVID-19 diagnosis using AI
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
Southern Medical University
2016-2025
Zhujiang Hospital
2016-2025
Soochow University
2025
UNSW Sydney
2016-2024
Chongqing Medical University
2008-2024
Anhui Medical University
2024
Capital Medical University
2019-2024
Beijing Tongren Hospital
2022-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Viral proteases are essential for pathogenesis and virulence of severe acute respiratory syndrome coronavirus (SARS-CoV). Little information is available on SARS-CoV papain-like protease 2 (PLP2), development inhibitors against PLP2 attractive antiviral therapy. Here, we report the characterization (from residues 1414 to 1858) purified from baculovirus-infected insect cells. We demonstrate that by itself differentially cleaves between amino acids Gly180 Ala181, Gly818 Ala819, Gly2740 Lys2741...
Emergence of severe acute respiratory syndrome (SARS) from the winter 2002 to spring 2003 has caused a serious threat public health.To evaluate safety and immunogenicity inactivated SARS coronavirus (SARS-CoV) vaccine, 36 subjects received two doses 16 SARS-CoV units (SU) or 32 SU placebo control.On day 42, seroconversion reached 100% for both vaccine groups. On 56, participants in group receiving 91.1% had seroconverted. The geometric mean titre neutralizing antibody peaked 2 weeks after...
To estimate influenza-associated mortality in urban China.Influenza-associated excess for the period 2003-2008 was estimated three cities temperate northern China and five subtropical south of country. The estimates were derived from models based on negative binomial regressions, vital statistics results weekly influenza virus surveillance.Annual mortality, all causes, 18.0 (range: 10.9-32.7) deaths per 100,000 population 11.3 7.3-17.8) southern cities. Excess respiratory circulatory disease...
Summary Background Currently, the prevention and control of novel coronavirus disease (COVID-19) outside Hubei province in China, other countries have become more critically serious. We developed validated a diagnosis aid model without computed tomography (CT) images for early identification suspected COVID-19 pneumonia (S-COVID-19-P) on admission adult fever patients made available via an online triage calculator. Methods Patients admitted from Jan 14 to February 26, 2020 with...
Currently, the need to prevent and control spread of 2019 novel coronavirus disease (COVID-19) outside Hubei province in China internationally has become increasingly critical. We developed validated a diagnostic model that does not rely on computed tomography (CT) images aid early identification suspected COVID-19 pneumonia (S-COVID-19-P) patients admitted adult fever clinics made available via an online triage calculator.Patients from January 14 February 26, 2020 with epidemiological...
The origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is contentious. Most studies have focused on a zoonotic origin, but definitive evidence such as an intermediary animal host lacking. We used established risk analysis tool for differentiating natural and unnatural epidemics, the modified Grunow-Finke assessment (mGFT) to study SARS-COV-2. mGFT scores 11 criteria provide likelihood or origin. Using published literature publicly available sources information, we applied...
MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) 2012 and has spread to 26 countries. However, 80% all cases have occurred KSA. The largest outbreak outside KSA South Korea (SK) 2015. In this report, we describe an epidemiological comparison two outbreaks. Data from 1299 (2012-2015) 186 SK (2015) were collected publicly available resources, including FluTrackers, World Health Organization (WHO) news MOH (MOH). Descriptive analysis, t-tests, Chi-square tests binary logistic...
<h3>BACKGROUND:</h3> Despite the high prevalence of weight loss in subjects with COPD, 2011 COPD management guidelines do not include an index measuring nutritional status. Fat-free mass (FFMI) can accurately determine status and may be closely correlated severity. We aimed to evaluated by FFMI according Global Initiative for Chronic Obstructive Lung Disease (GOLD) levels stable association between respiratory symptoms, exercise capacity, muscle function. <h3>METHODS:</h3> included 235 this...
The new 2019 coronavirus disease (COVID-19), according to the World Health Organization (WHO), has been characterized as a pandemic. As more is being discovered about this virus, we aim report findings of complete blood count (CBC) COVID-19 patients. This would serve in providing physicians with important knowledge on changes that can be expected from CBC mild and normal A total 208 common patients were admitted at Dongnan Hospital located city Xiaogan, Hubei, China. CBCs these patients,...
Vaccine derived poliovirus (VDPV) remains a major barrier to polio eradication, and recent growing emergences are concerning. This paper presents the global epidemiology of circulating VDPV (cVDPV) by exploring associations between demographic socioeconomic factors with its rise.Data on reported cVDPV cases isolates January 1 2016 June 30 2021 were compiled from EPIWATCH, an open-source observatory for outbreak scanning analysis, World Health Organisation (WHO) ProMed, analysed...
Human metapneumovirus (hMPV) is the main pathogen causing respiratory tract infection in susceptible populations, particularly children and elderly. Specimens were collected from hospitalized with acute lower infections (ALRTI), hMPV was detected by using real-time reverse transcription-PCR (RT-PCR). The full-length G gene of amplified RT-PCR. A total 1,410 nasopharyngeal aspirates (NPAs) April 2008 to March 2011, 114 (10.2%) positive for hMPV. Most hMPV-positive <5 years age. rate peaked...
Objective The goal of this study was to understand the knowledge about AIDS, identify correlates and determine prevalence HIV infection, syphilis, HCV among migrant workers in Zhejiang, China. Methods A cross-sectional using face-to-face anonymous questionnaire interviews conducted blood samples were collected for HIV, syphilis Hepatitis C infection screening. Results 17,377 (92.8%) 18,730 approached interviewed. Among participants, HIV/AIDS rate 66.2%. total 12,694 (73%) participants...
Abstract Background and Purpose Right ventricular (RV) function is the key prognostic determinant of pulmonary hypertension (PH). In PH patients, imatinib treatment decreases vascular resistance improves exercise capacity, but does not change mortality or duration to clinical worsening. Imatinib has been reported be cardiotoxic in left heart. We hypothesise that damages pressure overloaded RV via its direct effects within heart, which may counteract therapeutic haemodynamic improvement PH....
We built a SEIR (susceptible, exposed, infected, recovered) model of smallpox transmission for New York, USA, and Sydney, South Wales, Australia, that accounted age-specific population immunosuppression residual vaccine immunity conducted sensitivity analyses to estimate the effect these parameters might have on reemergence. At least 19% York's 17% Sydney's are immunosuppressed. The highest infection rates were in persons 0-19 years age, but death those >45 age. Because low level immunity,...
Human metapneumovirus (hMPV) has been reported to cause both upper and lower respiratory tract diseases in susceptible populations, particularly children the elderly. In this study, we describe a hospital-based epidemiological study of hMPV patients presenting children's hospital show demographic clinical characteristics associated with infection China, retrospectively. Specimens were collected over 2-year period from hospitalized acute infections (ALRTI) analyzed for presence using...
Background The coronavirus disease (COVID-19) outbreak in China was first reported to the World Health Organization (WHO) on December 31, 2019, and cases were officially identified around 8, 2019. Although origin of COVID-19 has not been confirmed, approximately half early linked a seafood market Wuhan. However, two documented patients did visit market. News reports, social media, informal sources may provide information about outbreaks prior formal notification. Objective aim this study...