A5100641647- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- interferon and immune responses
- Marine and coastal ecosystems
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Microbial Community Ecology and Physiology
- SARS-CoV-2 and COVID-19 Research
- Marine Toxins and Detection Methods
- Phagocytosis and Immune Regulation
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Mast cells and histamine
- Animal Virus Infections Studies
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Traditional Chinese Medicine Studies
- Invertebrate Immune Response Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Identification and Quantification in Food
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and Medication Impact
Duke Medical Center
2014-2025
Fudan University Shanghai Cancer Center
2025
Beijing Forestry University
2024
Capital Medical University
2024
Southern Medical University
2011-2023
Nanfang Hospital
2014-2023
Hebei Medical University
2012-2023
Fourth Hospital of Hebei Medical University
2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
Abstract Epidemiologic investigations showed that 2 of 4 patients with severe acute respiratory syndrome (SARS) identified in the winter 2003–2004 were a waitress at restaurant Guangzhou, China, served palm civets as food and customer who ate short distance from animal cages. All 6 positive for SARS-associated coronavirus (SARS-CoV). Partial spike (S) gene sequences SARS-CoV identical to 5 S viral civets. Phylogenetic analysis was most closely related isolates. SARS cases result recent...
ABSTRACT Massive numbers of palm civets were culled to remove sources for the reemergence severe acute respiratory syndrome (SARS) in Guangdong Province, China, January 2004, following SARS coronavirus detection market animals. The virus was identified all 91 and 15 raccoon dogs animal origin sampled prior culling, but not 1,107 later at 25 farms, spread over 12 provinces, which claimed be source traded Twenty-seven novel signature variation residues (SNVs) on spike gene analyzed their...
Emergence of severe acute respiratory syndrome (SARS) from the winter 2002 to spring 2003 has caused a serious threat public health.To evaluate safety and immunogenicity inactivated SARS coronavirus (SARS-CoV) vaccine, 36 subjects received two doses 16 SARS-CoV units (SU) or 32 SU placebo control.On day 42, seroconversion reached 100% for both vaccine groups. On 56, participants in group receiving 91.1% had seroconverted. The geometric mean titre neutralizing antibody peaked 2 weeks after...
<h3>Objectives</h3> Although myeloid-derived suppressor cells (MDSCs) have been linked to T cell tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we investigate the potential association of MDSCs with disease pathogenesis using a preclinical model RA and specimen collected from patients RA. <h3>Methods</h3> The frequency blood, lymphoid tissues, inflamed paws or synovial fluid severity, tissue inflammation levels pathogenic helper (Th) 17 were examined...
Drug resistance is a major obstacle to treating cancers because it desensitizes cancer cells chemotherapy. Recently, attention has been focused on changes in the tumor immune landscape after acquisition of drug resistance. Programmed death-ligand-1 (PD-L1) an suppressor that inhibits T cell-based immunity. Evidence shown acquired chemoresistance associated with increased PD-L1 expression cells. However, underlying mechanism still largely unknown.PD-L1 three drug-resistant A549/CDDP, MCF7/ADR...
To evaluate the efficacy of cytokine-induced killer (CIK) cell therapy in treatment hepatocellular carcinoma.Randomized phase II and III trials on CIK cell-based were identified by electronic searches using a combination "hepatocellular carcinoma" "cytokine-induced cells".The analysis showed significant survival benefit (one-year survival, p < 0.001; two-year median overall 0.001) favor CIK-based therapy. Comparison group versus non-CIK resulted significantly prolonged progression-free (PFS)...
This study aimed to investigate whether specific medications used in the treatment chronic diseases affected either development and/ or severity of coronavirus disease 2019 (COVID-19) a cohort 610 COVID-19 cases and 48,667 population-based controls from Zhejiang, China. Using 578 China, we tested role usage cardiovascular, antidiabetic, other on risk COVID-19. Analyses were adjusted for age, sex, body mass index presence relevant comorbidities. Individuals with hypertension taking calcium...
Glioma is the most prevalent and fatal primary tumor of central nervous system in adults, while development effective therapeutic strategies clinical practice remain a challenge. Nucleotide-binding domain leucine-rich family pyrin-containing 3 (NLRP3) has been reported to be associated with tumorigenesis progression; however, its expression function human glioma unclear. The present study was designed explore biological role potential mechanism NLRP3 glioma. results demonstrated that...
Terminal maturation of invariant NKT (iNKT) cells from stage 2 (CD44+NK1.1–) to 3 (CD44+NK1.1+) is accompanied by a functional acquisition predominant IFN-γ–producing (iNKT-1) phenotype; however, some develop into IL-17–producing iNKT (iNKT-17) cells. iNKT-17 are rare and restricted CD44+NK1.1– lineage. It unclear how terminal regulated what factors mediate the predominance iNKT-1 compared with iNKT-17. The tumor suppressor tuberous sclerosis 1 (TSC1) an important negative regulator mTOR...
Abstract Objective The spectrum of clinical manifestations and serological phenomena SLE is heterogeneous among patients even changes over time unpredictably in individual patients. For this reason, diagnosis especially complicated or atypical cases often difficult delayed leading to poor prognosis. Despite the medical progress nowadays understanding pathogenesis, disease-specific biomarkers for remain an outstanding challenge. Therefore, we undertook study investigate potential diagnosis....
Abstract Background: The widespread threat of severe acute respiratory syndrome (SARS) to human health has made urgent the development fast and accurate analytical methods for its early diagnosis a safe efficient antiviral vaccine preventive use. For this purpose, we investigated antigenicity different regions SARS coronavirus (SARS-CoV) nucleocapsid (N) protein. Methods: cDNA full-length N protein various from SARS-CoV was cloned expressed in Escherichia coli. After purification, all...
Abstract Negative feedback immune mechanisms are essential for maintenance of hepatic homeostasis and prevention immune-mediated liver injury. We show here that scavenger receptor A (SRA/CD204), a pattern recognition molecule, is highly up-regulated in the livers patients with autoimmune or viral hepatitis, mice during concanavalin (Con A)-induced hepatitis (CIH). Strikingly, genetic SRA ablation strongly sensitizes to Con A-induced loss, increased mortality pathology correlate excessive...
Regulatory T cells (Tregs) actively engage in immune suppression to prevent autoimmune diseases but also inhibit anti-tumor immunity. Although Tregs express a TCR repertoire with relatively high affinities self, they are normally quite stable and their inflammatory programs intrinsically suppressed. We report here that diacylglycerol (DAG) kinases (DGK) ( crucial for homeostasis, of proinflammatory programs, stability enforcing dependence on CD28 costimulatory signal. Treg-specific...