A5028408413- Phagocytosis and Immune Regulation
- Multiple Sclerosis Research Studies
- Myasthenia Gravis and Thymoma
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Peripheral Neuropathies and Disorders
- Natural product bioactivities and synthesis
- Acute Myeloid Leukemia Research
- Lung Cancer Research Studies
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Polyomavirus and related diseases
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- interferon and immune responses
- Catalytic C–H Functionalization Methods
- GDF15 and Related Biomarkers
- Neuroblastoma Research and Treatments
- Ferroptosis and cancer prognosis
- Antifungal resistance and susceptibility
- Sleep and Work-Related Fatigue
- Curcumin's Biomedical Applications
Capital Medical University
2025
Zunyi Medical University
2025
Lanzhou University Second Hospital
2019-2024
Lanzhou University
2019-2024
Second Affiliated Hospital of Nanjing Medical University
2017-2023
Nanjing Medical University
2015-2022
Northeast Normal University
2022
Nanjing Children's Hospital
2016
With the aging population, incidence of neurodegenerative diseases increases yearly, seriously impacting human health. Various journals have published studies on pathogenesis ferroptosis in diseases. However, bibliometric analysis this field is still lacking. The study aims to visually analyze global research trends over past decade.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Our research aimed to find immunomodulatory therapy for MS. An experimental autoimmune encephalomyelitis (EAE) mouse model MS was established induced with syntheticmyelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55). Fifty C57BL/6 mice were randomly divided into Normal group, EAE and Rapamycin group (EAE treated three different doses rapamycin). Hematoxylin eosin staining Weil...
Curcumin is widely used as a traditional drug in Asia. Interestingly, curcumin and its metabolites have been demonstrated to influence the microbiota. However, effect of on gut microbiota patients with myasthenia gravis (MG) remains unclear. This study aimed investigate effects community, short-chain fatty acids (SCFAs) levels, intestinal permeability, Th17/Treg balance Torpedo acetylcholine receptor (T-AChR)-induced MG mouse model. The results showed that significantly alleviated clinical...
Abstract Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). The present study explored role intestinal microbiota in initiation and propagation mice induced by experimental autoimmune encephalomyelitis (EAE), animal model multiple sclerosis. 48 C57BL/6 were randomly divided into control group EAE group. changes body weight scores neurological function recorded. mRNA expression receptor tyrosine kinase subfamily (AXL) was detected real-time quantitative...
Background Anoikis resistance (AR) plays an important role in the process of metastasis, which is factor affecting risk stage neuroblastoma (NB). This study aims to construct anoikis-related prognostic model and analyze characteristics hub genes, pathways tumor microenvironment subtypes NB, so as provide help for clinical diagnosis, treatment research NB. Methods We combined transcriptome data GSE49710 E-MTAB-8248, screened genes (Args) closely related prognosis NB by univariate cox...
Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, effect and underlying mechanism of on myasthenia gravis (MG) remain unclear. The changes in gut microbiota fecal contents SCFAs MG patients were examined. R97-116 peptide was used induce experimental autoimmune (EAMG) mice sodium (NaB) gavaged EAMG mice. Gut microbiota, frequency Th1, Th17, Treg, Tfh, B cells, levels IFN-γ, IL-17 A, IL-10, IL-21, anti-R97-116 IgG, RNA-seq total...
Abstract: The objective of this study was to investigate the anticancer efficacy dimercaptosuccinic acid-modified iron oxide magnetic nanoparticles coloaded with anti-CD22 antibodies and doxorubicin (anti-CD22-MNPs-DOX) on non-Hodgkin's lymphoma cells. physical properties anti-CD22-MNPs-DOX were studied its antitumor effect Raji cells in vitro evaluated using Cell Counting Kit-8 assay. Furthermore, cell apoptosis intracellular accumulation determined by flow cytometry. results revealed that...
Background The prognosis of MYCN positive NB is poor, and there no targeted drug for N-myc at present. This study aims to screen out hub genes closely related , analyze the relationship between microenvironment, provide basis molecular therapy NB. Methods We combined microarray data GSE45547 (n=649) GSE49710 (n=498), screened DEGs (n=185) negative (n=951), performed WGCNA, Lasso regression Roc analyses on merged matrix, obtained in training group. ssGSEA experimental group calculate...
Background Microglia participants to neuronal loss during brain development, inflammation, ischemia, and neurodegeneration. This bibliometric visualized study aimed confirm the top 100 cited original research in field analyze their characteristics. Methods The Web of Science database (WOS) was retrieved using specific search strategy. articles that focused on role microglia neurodegenerative diseases (NDs) were filtered by two researchers independently. trend yearly publications citations,...
Almost all hepatoblastomas are isolated to the liver. Hepatoblastoma arising from and limited extrahepatic tissue is an extremely rare clinical entity. Here we present a case of 7-year-old Chinese boy Han ethnicity with hepatoblastoma originating hepatogastric ligament. A complete resection was performed entire course uneventful. He received six cycles postoperative chemotherapy had no signs recurrence for 3 years after surgery. rare. pedunculated prone hemorrhage tumor metastasis. The best...
The imbalance in immune homeostasis plays a crucial role the pathogenesis of myasthenia gravis (MG). MicroRNAs (miRs) have been identified as key regulators homeostasis. B-cell lymphoma/leukemia 10 (BCL10) has implicated activation and suppressive function regulatory T cells (Tregs). This study aimed to investigate potential miR-155-5p modulating Tregs MG. To achieve this objective, blood samples were collected from MG patients assess expression levels BCL10, well proportion circulating...