A5100395664- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
- Liver Disease and Transplantation
- Respiratory viral infections research
- Cancer, Stress, Anesthesia, and Immune Response
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Food Allergy and Anaphylaxis Research
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Drug-Induced Hepatotoxicity and Protection
- Health and Wellbeing Research
- Multiple and Secondary Primary Cancers
- Antibiotic Resistance in Bacteria
Beijing University of Chinese Medicine
2023-2025
Peking University People's Hospital
2011-2025
Peking University
2006-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
The First People's Hospital of Changde
2025
Huazhong University of Science and Technology
2023-2024
Nanchang University
2024
First Affiliated Hospital of Guangzhou Medical University
2022-2024
State Key Laboratory of Respiratory Disease
2022-2024
Guangzhou Medical University
2010-2024
The burden of asthma in terms premature death or reduced quality life remains a huge issue. It is great importance to evaluate geographically and time trends from 1990 2019 assess the contributions age, period, cohort effects at global level.Asthma prevalence, deaths, disability adjusted years (DALYs) as well risk-attributable were collected Global Burden Diseases, Injuries, Risk Factors Study (GBD) database compared by age sex. Smoothing Splines models used estimate relationship between...
Population aging and the obesity epidemic are important global public health problems that pose an unprecedented threat to physical mental of elderly systems worldwide. Sarcopenic (SO) is a new category high-risk geriatric syndrome in elderly. SO associated with many adverse consequences such as frailty, falls, disability, increased morbidity mortality. The core mechanism vicious circle between myocytes adipocytes. In order implement effective prevention treatment strategies reduce clinical...
As cancers progress, they become increasingly aggressive—metastatic tumours are less responsive to first-line therapies than primary tumours, acquire resistance successive and eventually cause death1,2. Mutations largely conserved between metastatic from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression therapy resistance3–5. However, we lack an understanding of cell states mechanisms by which transition. Here, cohort biospecimen...
The alarmin cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) play a critical role in asthma pathogenesis by inducing mucosal Th2-type cytokine production. Although environmental exposure to aeroallergens has been proposed as an trigger asthma, there no systematic parallel study of the effects allergen on expression these airways human asthmatics. Using single sequential double immunohistochemistry, we evaluated numbers phenotypes IL-25-, IL-33-, TSLP-immunoreactive cells...
<h3>BACKGROUND:</h3> Despite the high prevalence of weight loss in subjects with COPD, 2011 COPD management guidelines do not include an index measuring nutritional status. Fat-free mass (FFMI) can accurately determine status and may be closely correlated severity. We aimed to evaluated by FFMI according Global Initiative for Chronic Obstructive Lung Disease (GOLD) levels stable association between respiratory symptoms, exercise capacity, muscle function. <h3>METHODS:</h3> included 235 this...
Background Chronic obstructive pulmonary disease (COPD) has been considered a of the elderly, but it could also occur in young people aged 20–50 years. However, characteristics and prognosis COPD such remain unclear. Methods Our retrospective cohort study was based on National Health Nutrition Examination Survey (NHANES). Participants who years old at baseline completed function test were enrolled our cohort. These participants followed up to 31 December 2019. The sample weight Taylor...
Metastasis is the principal cause of cancer death, yet we lack an understanding metastatic cell states, their relationship to primary tumor and mechanisms by which they transition. In a cohort biospecimen trios from same-patient normal colon, colorectal cancer, show that while tumors largely adopt LGR5 + intestinal stem-like metastases display progressive plasticity. Loss states accompanied reprogramming into highly conserved fetal progenitor state, followed non-canonical differentiation...
Abstract Corneal neovascularization (CoNV) is a major cause of visual impairment worldwide. Currently, available treatment options have limited efficacy and are associated with adverse effects due to biological barriers clearance mechanisms. To address this challenge, novel topical delivery system developed—Gel 2_1&Eylea —an aflibercept‐loaded eye‐drop hydrogel mediated cell‐penetrating peptide 1 . Gel demonstrates superior membrane permeability, increased stability, prolonged drug...
Severe asthma is a complex and heterogeneous chronic airway inflammatory disease. Current treatment strategies are increasingly focused on disease classification, facilitating the transition towards personalized medicine by integrating biomarkers monoclonal antibodies for tailored therapeutic approaches. Several approved biological agents, including anti-immunoglobulin E (IgE), anti-interleukin (IL)-4, anti-IL-5, anti-thymic stromal lymphopoietin (TSLP) antibodies, have demonstrated...
Abstract Background and Objective The use of small airway parameters generated by spirometry, namely forced expiratory flow between 25% 75% vital capacity (FVC) (FEF 25%–75% ) at 50% FVC FEF , respectively), is widely discussed. We evaluated the importance these spirometric in a large Chinese population. Methods conducted cross‐sectional observational study which spirometry bronchodilator responsiveness (BDR) data were collected healthcare centre from May 2021 to August 2022 tertiary...
Objectives The objective of this study was to compare the image quality and radiation dose chest CT images reconstructed with a blend adaptive statistical iterative reconstruction (ASIR) filtered back-projection (FBP) generated using conventional FBP. Methods Patients re-examinations were alternately assigned two scanners different techniques. groups included noise index (NI) 11 30% ASIR (A30), NI 13 40% (A40), 15 50% (A50) 17 60% (A60), sequentially changed every 2 months. control obtained...
During gestation, placental blood flow, endothelial nitric oxide (NO) production, and cell synthase (eNOS) expression are elevated dramatically. Shear stress can induce flow-mediated vasodilation, NO eNOS expression. Both the activity of closely regulated because it is rate-limiting enzyme essential for synthesis. The authors adapted CELLMAX artificial capillary modules to study effects pulsatile flow/shear on ovine fetoplacental artery (OFPAE) expression, phosphorylation. This model allows...
Abstract The effect of antigen specific immunotherapy (SIT) on asthma is supposed to be improved. Published data indicate that administration probiotics alleviates allergic diseases. B cells play important roles in the pathogenesis This study aims modulate cell property by Clostridium butyrate ( CB ) combination with SIT. results showed after a 3-month treatment, total clinical score and serum IgE were improved patients treated SIT, which was further those both SIT , but not alone. Treatment...
In the 2021 ERS/ATS interpretive strategies for routine lung function tests, a positive bronchodilator response (BDR) was updated as change of >10% relative to predicted value in forced expiratory volume 1 second (FEV1) or vital capacity (FVC). We aimed explore differences between 2005 and criteria applied patients with asthma well chronic obstructive pulmonary disease (COPD).BDR test data about aged 6-80 years COPD 18-80 were derived from National Respiratory Medicine Center, First...
Introduction The well-being of patients with chronic diseases is an issue widespread concern in public health. While social support thought to have a positive effect on it, the mechanisms its influence not been fully addressed. Thus, we explored possible mediating effects self-efficacy and perceived stress determine relationship between these patients. Methods A cross-sectional study was conducted among 4,657 China. PROCESS Macro model 6 SPSS employed explore intermediary role variables....
Abstract This study was performed to assess how the degree of uterine prolapse affects anterior pelvic compartment using transperineal ultrasound. single-center, retrospective included 287 patients with as assessed by The were categorized into mild and severe groups based on severity prolapse. All underwent floor ultrasonography, during which bladder neck descent, lowest point bladder, retrovesical angle, urethral tilt rotation angle observed classify cystocele types. In group, 38.2% (37/97)...
Lymphovascular invasion (LVI) has not been included in the tumor-node-metastasis (TNM) staging manual of non-small-cell lung cancer (NSCLC). We aimed to investigate predictive value LVI on stage IA NSCLC and proposed a method incorporating into T category based latest TNM manual.The least absolute shrinkage selection operator (LASSO)-penalized Cox multivariable regression model was performed identify prognostic factors. The Kaplan-Meier used compare overall survival (OS) disease-free (DFS)...