A5101537033- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Cholesterol and Lipid Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Immune cells in cancer
- Global trade and economics
- Global Trade and Competitiveness
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Blood properties and coagulation
- Wound Healing and Treatments
- Economics of Agriculture and Food Markets
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Lipid metabolism and disorders
- Complement system in diseases
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- RNA modifications and cancer
First Affiliated Hospital of Soochow University
2015-2025
Soochow University
2015-2025
Institute of Geographic Sciences and Natural Resources Research
2024-2025
Chinese Academy of Sciences
2012-2025
University of Chinese Academy of Sciences
2024-2025
Xinjiang Institute of Ecology and Geography
2025
University of Rome Tor Vergata
2023-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Huazhong University of Science and Technology
2024
Nanjing Agricultural University
2010-2023
Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has been implicated in lung tumorigenesis. However, functional links between regulation and are not well understood. Here we identify RNA-binding protein QKI as a key regulator alternative cancer. We show that frequently down-regulated cancer, its down-regulation significantly associated with poorer prognosis. QKI-5 inhibits proliferation transformation cells both vitro vivo. Our results demonstrate...
Abstract Despite the widespread use of blockade immune checkpoints, for a significant number cancer patients, these therapies have proven ineffective, presumably due to immunosuppressive nature tumor microenvironment (TME). Critical drivers escape in TME include tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), which not only mediate suppression, but also facilitate metastatic dissemination impart resistance immunotherapies. Thus, strategies that convert them...
Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Here we find that lung mesenchymal stromal (LMSCs) at pre-metastatic stage possess potent metastasis-promoting activity. RNA-seq reveals an upregulation complement 3 (C3) those LMSCs. C3 found to promote neutrophil recruitment and extracellular traps (NETs), which facilitate cell metastasis lungs. expression LMSCs induced sustained by Th2 cytokines a STAT6-dependent manner....
TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits increases the flow of pentose phosphate pathway (PPP), which generates NADPH pentose. We hypothesized that TIGAR plays a neuroprotective role in brain ischemia as neurons do not rely on but are vulnerable to oxidative stress. found was highly expressed rapidly upregulated response ischemia/reperfusion insult TP53-independent manner. Overexpression normal mice with lentivirus reduced ischemic neuronal injury, whereas...
Distinct metabolic programs, either energy-consuming anabolism or energy-generating catabolism, were required for different biological functions. Macrophages can adopt immune phenotypes in response to various cues and exhibit anti- pro-inflammatory properties relying on catabolic pathways associated with oxidative phosphorylation (OXPHOS) glycolysis. Spermidine, a natural polyamine, has been reported regulate inflammation through inducing anti-inflammatory (M2) macrophages. However, the...
The human Y box-binding protein-1 (YB-1) is a deoxyribonucleic acid (DNA)/ribonucleic (RNA)-binding protein with pleiotropic functions. Besides its roles in the regulation of transcription and translation, several recent studies indicate that YB-1 spliceosome-associated involved alternative splicing, but underlying mechanism has remained elusive. Here, we define both CAUC CACC as high-affinity binding motifs for by systematic evolution ligands exponential enrichment (SELEX) demonstrate these...
Sitosterolemia (phytosterolemia) is a rare inherited sterol storage disorder, characterized by significantly elevated plasma levels of plant sterols. The clinical features sitosterolemia are xanthomas, premature atherosclerosis, arthritis, and, occasionally, liver function impair and hematologic abnormalities. This disorder caused mutations ABCG5/ABCG8 genes. We report here the clinical, laboratory, molecular genetic 13 patients with from eight unrelated families who had specific problems...
• Villin is one of the major actin filament bundling proteins in plants. The function Arabidopsis VILLINs (AtVLNs) still poorly understood living cells. In this report, biochemical activity and cellular AtVLN4 were examined. property was characterized by co-sedimentation assays, fluorescence microscopy spectroscopy pyrene fluorescence. vivo analysed ectopically expressing it tobacco pollen examining phenotypes its T-DNA insertional Recombinant protein exhibited multiple activities on actin,...
Our previous study has defined a role of TP53-induced glycolysis and apoptosis regulator in neuroprotection against ischemic injury through increasing the flow pentose phosphate pathway. We hypothesized that pathway product nicotinamide adenine dinucleotide (NADPH) could be novel drug for treatment stroke.The NADPH was given before, at onset, or after stroke onset with single repeated intravenous (mice rats) intraperitoneal injections (monkey). The short- long-term therapeutic effects were...
Purpose The outbreak of the novel COVID-19 virus has spread throughout world, causing unprecedented disruption to not only China's agricultural trade but also world's at large. This paper attempts provide a preliminary analysis impact pandemic on importing and exporting from both short- long-term perspectives. Design/methodology/approach study seeks analyze how could potentially trade. With respect exports, authors have pinpointed major disruptive factors arising which affected exports in...
Abstract Skin is the largest organ of human body. wound one most common forms wound. Mesenchymal stromal cells (MSCs) have been used to aid skin healing via their paracrine factors. Because secretome MSCs can be greatly enriched and amplified by treatment with IFN-γ TNF-α (IT), we here tested whether supernatant derived from pretreated IT, designated as S-MSCs-IT, possesses improved effect using a murine model cutaneous excision, S-MSCs-IT was found more potent in promoting angiogenesis,...
Abstract Background Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue cells, especially mesenchymal (MSCs), can exert therapeutic effects on various degenerative inflammatory disorders based their immunoregulatory properties. Human (hMSCs) treated with interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) were reported to possess anti-inflammatory functions by producing...
Apoptosis delimits platelet life span in the circulation and leads to storage lesion, which severely limits shelf of stored platelets. Moreover, accumulating evidence indicates that apoptosis provoked by various pathological stimuli results thrombocytopenia many common diseases. However, little is known about how initiated or regulated. Here, we show PKA activity markedly reduced platelets aged vitro, platelets, from patients with immune (ITP), diabetes, bacterial infections. Inhibition...
Abstract The dome-shaped cornea is a transparent, non-vascularized, and epithelialized highly organized tissue. Physical chemical injuries may trigger corneal wound healing (CWH) response result in neovascularization that impairs the visual function. CWH involves not only migration, proliferation, differentiation of cells different layers cornea, but also mobilization immune cells. We demonstrated here human adipose-derived mesenchymal stromal (ADSCs) could effectively inhibit during...
The immune reconstitution after initiation of highly active antiretroviral therapy (HAART) among HIV-infected individuals substantially affects patients' prognosis. However, the dynamic characteristics and predictors outcome remain unclear. In this study, HIV/AIDS patients with sustained virological suppression (viral load < 50 copies/ml) HAART were enrolled. subgrouped into immunological non-responders (INRs) (< 200 cells/μl), inadequate responders (IIRs) (200 ~ 500 cells/μl) (IRs) (>...
Abstract Glucocorticoids (GC) are widely used clinically, despite the presence of significant side effects, including glucocorticoid-induced osteoporosis (GIOP). While GC believed to act directly on osteoblasts and osteoclasts promote osteoporosis, detailed underlying molecular mechanism GC-induced is still not fully elucidated. Here, we show that lymphocytes play a pivotal role in regulating osteoporosis. We GIOP could be induced SCID mice lack T cells, but it re-established by adoptive...
We conducted this randomized trial to investigate the efficacy and safety of rapamycin treatment in adults with chronic immune thrombocytopenia (ITP). Eighty-eight patients were separated into control (cyclosporine A plus prednisone) experimental (rapamycin groups. The CD4 + CD25 CD127 low regulatory T (Treg) cells level, Foxp3 mRNA expression, relevant cytokines levels measured before after treatment. overall response (OR) was similar both groups (experimental group versus group: 58%...