A5100357089- Gut microbiota and health
- Diet and metabolism studies
- Effects of Radiation Exposure
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Animal Nutrition and Physiology
- Metabolomics and Mass Spectrometry Studies
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Traditional Chinese Medicine Studies
- Nanoplatforms for cancer theranostics
- Tryptophan and brain disorders
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Environmental Toxicology and Ecotoxicology
- NF-κB Signaling Pathways
Second Hospital of Shandong University
2025
Gansu University of Traditional Chinese Medicine
2019-2024
Sun Yat-sen University
2024
Second Affiliated Hospital of Soochow University
2017-2024
Soochow University
2017-2024
Weifang Medical University
2017-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
Dalian University of Technology
2023
First Hospital of Lanzhou University
2022
Lanzhou University
2022
Akkermansia muciniphila is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes. However, whether A. can improve inflammatory bowel diseases (IBD), which a form of chronic intestinal dysbiosis, unknown. Hence, we used an isolated murine (designated 139) ATCC, to investigate their anti-inflammatory properties cell models Dextran Sulfate Sodium (DSS)-induced colitis mice. In vitro, the two strains exerted similar as they both reduced IL-8...
Calorie restriction (CR), which has a potent anti-inflammaging effect, been demonstrated to induce dramatic changes in the gut microbiota. Whether modulated microbiota contributes attenuation of inflammation during CR is unknown, as are members microbial community that may be key mediators this process. Here, we report unique Lactobacillus-predominated was rapidly attained mice within 2 weeks CR, decreased levels circulating antigens and systemic inflammatory markers such tumour necrosis...
Carbon ion radiotherapy (CIRT) is an emerging type of for the treatment solid tumors. In recent years, evidence accumulated that CIRT improves therapeutic outcome in patients with otherwise poor response to immune checkpoint blockade. Here, we aimed at identifying underlying mechanisms CIRT-induced tumor immunogenicity and efficacy. We used human U2OS osteosarcoma cells vitro assessment immunogenic cell death established several vivo models melanoma mice. treated animals conventional...
In our previous study, we provided evidence that Astragalus mongholicus Bunge(AM) and its extracts possess a protective capability against radiation-induced damage, potentially mediated through the reduction of reactive oxygen species (ROS) nitric oxide (NO). However, were pleasantly surprised to discover during experimentation AM not only offers protection radiation damage but also exhibits sensitization effect. This effect may be attributed specific small molecule present in known as...
Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need be further clarified, and associated treatment approaches require exploration. The NOD‑like receptor thermal protein domain 3 (NLRP3) inflammasome serves an important role in causing CIRI, its activation exacerbates underlying injury. Activation NLRP3 triggers maturation production inflammatory molecules IL‑1β IL‑18, as well gasdermin‑D‑mediated...
Ischemic stroke is a refractory disease wherein the reperfusion injury caused by sudden restoration of blood supply main cause increased mortality and disability. However, current therapeutic strategies for inflammatory response induced cerebral ischemia-reperfusion (I/R) are unsatisfactory. This study aimed to develop functional nanoparticle (MM/ANPs) comprising apelin-13 (APNs) encapsulated in macrophage membranes (MM) modified with distearoyl phosphatidylethanolamine-polyethylene...
MicroRNAs (miRNAs) play important roles in the cancer development and progression; overexpression of miR-103 has been identified various tumors. However, its biological function regulatory mechanism involved modulation human gastric (GC) remain largely unknown. This study aimed to confirm clinical significance investigate role underlying GC. Real-time quantitative PCR (qRT-PCR) revealed was highly expressed GC tissues cell lines. expression correlated closely with tumor size, Lauren's...
Abstract CD73, an ecto‐enzyme overexpressed in breast‐cancer cells, catalyzes the dephosphorylation of adenosine monophosphates into adenosine. Anti‐CD73 slows breast cancer growth and its spread both vivo vitro . In this study, we investigated relation CD73 to epidermal factor receptor (EGFR) expression using tissue array cell lines. We found that correlated positively EGFR ( n = 80, r 0.425, P < 0.01) can be decreased by suppressing with inhibitor or small shRNA, effect was reversed...
Metabolic syndrome (MetS) is a constellation of cardiovascular risk factors, including central obesity, dysglycemia, hypertension, and dyslipidemia. The anti-inflammatory properties high density lipoprotein (HDL) can be compromised in MetS. Exercise recognized as an important factor the prevention treatment MetS.This study was designed to investigate whether walk/run training without any specific diet could enhance anti-inflammation capacity HDL from MetS patients.This case control study.The...
Abstract Glucocorticoids (GC) are widely used clinically, despite the presence of significant side effects, including glucocorticoid-induced osteoporosis (GIOP). While GC believed to act directly on osteoblasts and osteoclasts promote osteoporosis, detailed underlying molecular mechanism GC-induced is still not fully elucidated. Here, we show that lymphocytes play a pivotal role in regulating osteoporosis. We GIOP could be induced SCID mice lack T cells, but it re-established by adoptive...
Introduction. To investigate the effects of acupuncture on endogenous metabolites in liver type 2 diabetes mellitus (T2DM) with nonalcoholic fatty disease (NAFLD) mice-based metabolomics. Methods. Proton nuclear magnetic resonance (1H-NMR) metabolomics combined multivariate statistical analysis and univariate were used to analyze changes mice each group provide new clinical ideas for treatment glycolipid metabolism disorders caused by T2DM NAFLD. Results. After 4 weeks continuous treatment,...
BACKGROUND The tumor microenvironment in lung cancer plays an important role progression and metastasis. Bone marrow-derived mesenchymal stem cells (MSCs) co-cultured with A549 show changes morphology, increase cell proliferation, migration. This study aimed to investigate the effects of Astragalus polysaccharide (APS), a traditional Chinese herbal medicine, on induced bone MSCs by vitro. MATERIAL AND METHODS were (Co-BMSCs). Co-cultured treated 50 μg/ml APS (Co-BMSCs + APS) compared...
Numerous studies have shown that carbon ion radiotherapy (CIRT) induces anti-cancer immune responses in melanoma patients, yet the mechanism remains elusive. The abundance of myeloid-derived suppressor cells (MDSC) tumour microenvironment is associated with therapeutic efficacy and disease outcome. This study analysed changes contexture response to treatment. murine B16, MelanA, S91 models were established syngeneic immunocompetent mice. Then, tumours irradiated beams, flow cytometry was...
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), a novel contaminant derived from tire wear, has raised concerns due to its potential neurotoxicity, yet long-term effects on mammalian neurological health remain poorly understood. This study investigates the neurotoxic and neuroinflammatory impacts of prolonged 6-PPDQ exposure using male C57BL/6 mice. Behavioral assessments revealed significant cognitive deficits, while biochemical analyses demonstrated increased levels...
Traditional Chinese acupuncture has been demonstrated to be beneficial for treatment of type 2 diabetes mellitus (T2DM). The mechanism on T2DM is crucial their biological activity as well usefulness tools in biology and medicine. However, its poorly understood.In an effort explore the mechanism, eight db/db mice (a spontaneous mouse) were treated with adjusting internal organs dredging channel electroacupuncture (AODCEA) weeks. Another fed group (T2DMG), db/m set normal control (NCG)....
This study was conducted to investigate the effects of 1,8-cineole on antioxidant capacity, immunity, and intestinal health broilers. A total 540 1-day-old Arbor Acres (AA) male broilers were randomly divided into five treatments with six replicates per treatment, 18 replicate for 42 days. Dietary a corn−soybean meal basal diet supplemented 0, 10, 20, 30, 40 mg/kg 1,8-cineole, respectively. supplementation 20~30 increased ADG from d 22 1 (p < 0.05), decreased FCR 0.05). 10~40 capacity (TAOC)...
The in vivo and vitro metabolism of genipin was systematically investigated the present study. Urine, plasma, feces, bile were collected from rats after oral administration at a dose 50 mg/kg body weight. A rapid sensitive method using ultraperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF MS) developed for analysis metabolic profile rat biological samples (urine, bile). total ten metabolites detected...
Abstract Background and purpose Intestinal inflammation gut microbiota dysbiosis contribute to Parkinson disease (PD) pathogenesis, growing evidence suggests associations between inflammatory bowel diseases (IBD) PD. Considered as markers of chronic gastrointestinal inflammation, elevated serum anti‐ Saccharomyces cerevisiae antibody (ASCA) levels, against certain fungal components, are related IBD, but their effect on PD is yet be investigated. Methods Serum ASCA IgG IgA levels were...
Abstract Aging is always accompanied by chronic diseases which probably attribute to long‐term inflammation in the aging body. Whereas, mechanism of body still obscure. Mesenchymal stem cells (MSCs) are capable local chemotaxis sites and play a powerful role immune regulation. Whether degeneration MSCs associated with unbalanced not clear. In this study, immunosuppressive properties aged found be repressed. The impaired function lower expression Hippo effector Yes‐associated protein 1 (YAP1)...
Abstract Functional activation of T cells requires ligation Ag receptors with specific peptides presented by MHC molecules on APCs concurrent appropriate contacts cell surface accessory molecules. Among these molecules, interactions between CD28/CTLA-4 B7 family members (CD80 and CD86) CD40 ligand (CD40L) play a decisive role in regulating the progression balanced immune responses. However, most information regarding responses has been derived context signals from TCRs. Little understanding...