A5050871340- Mesenchymal stem cell research
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Glioma Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Muscle Physiology and Disorders
- Brain Metastases and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Neurogenesis and neuroplasticity mechanisms
- Proteoglycans and glycosaminoglycans research
- Exercise and Physiological Responses
- Plant Ecology and Soil Science
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Fibroblast Growth Factor Research
- Soil Carbon and Nitrogen Dynamics
- Extracellular vesicles in disease
- Forest, Soil, and Plant Ecology in China
- Gout, Hyperuricemia, Uric Acid
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
Nanchong Central Hospital
2025
Capital Medical University
2025
Soochow University
2020-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Qiqihar Medical University
2023-2024
First Affiliated Hospital of Soochow University
2020-2023
University of Rome Tor Vergata
2020-2023
Guilin Medical University
2021
University of Jinan
2019
Distinct metabolic programs, either energy-consuming anabolism or energy-generating catabolism, were required for different biological functions. Macrophages can adopt immune phenotypes in response to various cues and exhibit anti- pro-inflammatory properties relying on catabolic pathways associated with oxidative phosphorylation (OXPHOS) glycolysis. Spermidine, a natural polyamine, has been reported regulate inflammation through inducing anti-inflammatory (M2) macrophages. However, the...
Abstract Background Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue cells, especially mesenchymal (MSCs), can exert therapeutic effects on various degenerative inflammatory disorders based their immunoregulatory properties. Human (hMSCs) treated with interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) were reported to possess anti-inflammatory functions by producing...
Diabetic nephropathy (DN) is one of the main complications diabetes mellitus (DM), which leads to long-term loss kidney functions. Long noncoding RNAs (LncRNAs) can alleviate DN by interacting with microRNAs (miRNAs). In this work, we aimed explore effects MALAT1/miR-200c/NRF2 regulatory axis on pyroptosis and oxidative stress (Oxidative stress, OS) renal podocytes in high glucose (HG) environment whether lipid-lowering drug atorvastatin (AT) relieve OS through approach. MPC-5, a mouse...
Cytokines produced by immune cells have been demonstrated to act on muscle stem (MuSCs) and direct their fate behavior during repair regeneration. Nevertheless, it is unclear whether how MuSCs can also in turn modulate the properties of cells. Here, we showed that vitro expanded exhibited a potent anti-inflammatory effect when infused into mice suffering from inflammatory bowel disease (IBD). Supernatant conditioned similarly ameliorated IBD. This beneficial was not observed macrophages were...
Muscle stem cells (MuSCs) have been demonstrated to exert impressive therapeutic efficacy in disease settings through orchestrating inflammatory microenvironments. Nevertheless, the mechanisms underlying immunoregulatory property of MuSCs remain largely uncharacterized. Here, we showed that interleukin-4-induced-1 (IL4I1), an essential enzyme catalyzes indole metabolism humans, was highly expressed human exposed IFN-γ and TNF-α. Functionally, were found inhibit infiltration neutrophils into...
Bone marrow mesenchymal stem cell (BMSCs) -based therapies represent a promising treatment for neurological disorders. However, therapeutic effects and mechanisms of BMSCs transplantation radiation-induced brain injury (RIBI) have not been fully disclosed. In this article, we explored the functions on RIBI investigated protective BMSCS hippocampal neurons in as well related molecular mechanisms. 6–8 weeks-old rats were used to build model. Rats BMSC group treated with 3 × 106 injection...
Bone marrow mesenchymal stem cells (BMSCs) have demonstrated potential in the treatment of radiation-induced brain injury (RIBI); however, presence blood-brain barrier (BBB) limits their therapeutic efficacy. Additionally, precise mechanisms behind use BMSCs treating RIBI are still not well understood. This study aimed to investigate efficacy mannitol and on neuronal autophagy RIBI. In study, models were first established male Sprague-Dawley (SD) rats. Evans blue staining was performed...
Muscle stem cells (MuSCs) are effective in treating inflammatory diseases driven by overactive innate immune responses, such as colitis and acute lung injury, due to their immunomodulatory properties. However, potential adaptive responses is still uncertain. When primed with cytokines, MuSCs strongly suppressed T cell activation proliferation vitro co-culture activated splenocytes or peripheral blood mononuclear cells. Systemic administration of from both mice humans alleviated pathologies...
The role of bone marrow mesenchymal stem cells (BMSCs) in treating radiation-induced brain injury (RIBI) is not completely understood, and assessment methods to directly characterize neurological function are lacking. In this study, we aimed evaluate the effects BMSCs treatment on changes hippocampal neural Sprague–Dawley(SD) rats with RIBI, therapeutic effect by manganese-enhanced magnetic resonance imaging (MEMRI). First, assessed cognitive after RIBI using Morris water maze. Next, used...
Abstract Objective Single-cell technologies have revolutionized our understanding of the phenotypic and transcriptional diversity aortic leukocytes in atherosclerotic humans mice. However, enzymatically dissociated tissues lose spatial context plaque cells situ . Here we utilized imaging mass cytometry (IMC) combining with single-cell RNA sequencing (scRNA-seq) to characterize distribution dynamics, transitions, metabolic functional phenotypes, intercellular interaction networks during...
Abstract Muscle stem cells (MuSCs) have been demonstrated to exert impressive therapeutic efficacy in disease settings through orchestrating inflammatory microenvironments. Nevertheless, the mechanisms underlying immunoregulatory property of MuSCs remain largely uncharacterized. Here, we showed that interleukin-4-induced-1 (IL4I1), an essential enzyme catalyzes indole metabolism humans, was highly expressed human exposed IFN-γ and TNF-α. Functionally, were found inhibit infiltration...
Soil organic carbon (SOC) is one of the important properties to evaluate soil quality, which can indirectly reflect effect afforestation on saline-alkali land. In this study, 4 different forest types in Gudao Forestry Centre were selected as experimental plots, and bare land was set blank group. Spatial differentiation impact factors SOC between studied by field investigation laboratory experiment. The results show that (1) content study area lower than 1%. higher upper layer, Robinia...