A5007682162- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Enzyme Catalysis and Immobilization
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Combustion and Detonation Processes
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Protein Tyrosine Phosphatases
- Tryptophan and brain disorders
- Synthesis and biological activity
- Proteoglycans and glycosaminoglycans research
- Enzyme Production and Characterization
- Synthesis and Biological Evaluation
- Chemical Synthesis and Reactions
- Legume Nitrogen Fixing Symbiosis
- Bioactive Compounds and Antitumor Agents
- Fluorine in Organic Chemistry
- Energetic Materials and Combustion
- Cancer therapeutics and mechanisms
- Chemical synthesis and alkaloids
Peking University
2015-2025
Shandong University of Science and Technology
2011-2022
Shenzhen University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2019
State Administration of Traditional Chinese Medicine of the People's Republic of China
2018-2019
Ministry of Education of the People's Republic of China
2018-2019
China Pharmaceutical University
2018
Nanjing University
2018
State Key Laboratory of Natural and Biomimetic Drugs
2011-2018
Food and Drug Administration
2011-2018
Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 known inhibit cell vitro vivo. However, whether SHP099-mediated inhibition retards vivo via anti-tumor immunity remains elusive. To address this, CT-26 colon xenograft model was established mice since this line insensitive SHP099. Consequently, minimally affected immuno-deficient nude mice, but...
Diabetes is associated with a high risk of developing cognitive dysfunction and neuropsychiatric disabilities, these disease symptomsare termed diabetic encephalopathy (DEP). Inflammation involved in the development DEP. The cleavage maturation proinflammatory cytokine interleukin (IL)-1β regulated by NLRP3 inflammasome. Obese type 2 db/db mice show anxiety- depression-like behaviors disorders hippocampal inflammation. purpose this study was to explore role inflammasome Results showed that...
Abstract Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through production gut-derived metabolites. However, specific metabolites and their pathophysiological contribution cardiac hypertrophy or heart failure progression still remain unclear. N,N,N-trimethyl-5-aminovaleric acid (TMAVA), derived from trimethyllysine gut microbiota, was elevated with gradually increased risk mortality transplantation in a prospective...
A convenient, metal-free intramolecular aminofluorination of alkenes has been developed. Employing readily available PhI(OPiv)2 and hydrogen fluoride–pyridine in the presence BF3·OEt2, tosyl-protected pent-4-en-1-amines were converted to 3-F-piperidines one step good yields as well high stereoselectivity.
We have developed a new KI-catalyzed method for the imidation of an sp3 C–H bond adjacent to amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as oxidant. This novel procedure tolerated air and moisture provided series products in moderate excellent yields under mild conditions.
Selective syn and anti diacetoxylations of alkenes have been achieved using a PhI(OAc)(2)/BF(3)·OEt(2) system in the presence absence water, respectively. A broad range substrates including electron-deficient (such as α,β-unsaturated esters) could be elaborated efficiently at room temperature with this methodology, furnishing desired products good to excellent yields diastereoselectivity. In particular, multigram-scale diastereoselective diacetoxylation methyl cinnamate (5.00 g) was also...
A novel method for the organocatalytic syn diacetoxylation of alkenes has been developed using aryl iodides as efficient catalysts. broad range substrates, including electron-rich well electron-deficient alkenes, are smoothly transformed by new procedure, furnishing desired products in good to excellent yields with high diastereoselectivity (up >19:1 dr).
A metal-free method for the direct regioselective fluorination of anilides has been developed. In presence bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)(2)) and hydrogen fluoride-pyridine, para-fluorination products were obtained in moderate to good yields. Because its operational safety use readily available reagents, this new procedure provides facile access a variety para-fluorinated anilides.
Doxorubicin (Dox) is one of the most effective and widely used anthracycline antineoplastic antibiotics. Unfortunately, use Dox limited by its cumulative dose-dependent cardiac toxicity. Myricitrin, a natural flavonoid which isolated from ground bark Myrica rubra, has recently been found to have strong antioxidative effect. This study aimed evaluate possible protective effect myricitrin against Dox-induced cardiotoxicity underlying mechanisms. An in vivo investigation SD rats demonstrated...
Well-dispersed Ni and Sm<sub>2</sub>O<sub>3</sub> nanoparticles embedded in an ordered mesoporous Al<sub>2</sub>O<sub>3</sub> material simultaneously exhibit high catalytic activity stability for the CO methanation reaction.
Aberrant activation of the NLRP3 inflammasome contributes to onset and progression various inflammatory diseases, making it a highly desirable drug target. In this study, we screened series small compounds with anti-inflammatory activities identified novel inhibitor, AI-44, curcumin analogue that selectively inhibited signal 2 but not 1 activation. We demonstrated AI-44 bound peroxiredoxin (PRDX1) promoted interaction PRDX1 pro-Caspase-1 (CASP1), which led suppression association pro-CASP1...
Depression is a chronic and recurrent syndrome of mood disorder causing immense social economic burden; thus, treatment should be improved. Guanxin Danshen formula (GXDSF), natural botanical drug composition prescription, has significant cardiovascular protective effects widely used in the clinical myocardial ischaemic diseases. However, it still unclear seldom studied whether GXDSF neuroprotective against depressive disorders. This study explored antidepressant-like rats exposed to...
Abstract Fucosylated chondroitin sulfate (FuCS) is a structurally distinct glycosaminoglycan with excellent anticoagulant activity. Studies show that FuCS and its depolymerized fragments exhibit different mechanism from of heparin derivatives, decreased risks adverse effects bleeding. However, further exploitation has been hindered by the scarcity defined oligosaccharides. Herein, facile method reported for synthesis repeating trisaccharide unit based on degradation polymers. A series...
Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum pharmacological effects, has been achieved starting from 2,3,4,6-tetra-O-benzyl-α/β-d-glucopyranose. The key steps involve stereoselective Lewis acid promoted C-glycosylation protected phloroglucinol tetrabenzylglucopyranosyl acetate highly regioselective base-induced cyclization for the construction core skeleton.
An improved method for the synthesis of large and complex oligosaccharides on ionic liquid (IL) support was developed. A strategy to attach acceptor IL using a more stable ether linker used prevent undesirable decomposition side products. "dissolution–evaporation–precipitation" purification procedure also developed by combining advantages precipitation solid–liquid extraction reduce mechanical loss time. This approach successfully rapid assembly supported homolinear α(1→2)-linked...