A5090336939- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- GNSS positioning and interference
- Geophysics and Gravity Measurements
- Immunotherapy and Immune Responses
- Ionosphere and magnetosphere dynamics
- Astrophysical Phenomena and Observations
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Adversarial Robustness in Machine Learning
- Inertial Sensor and Navigation
- Seaweed-derived Bioactive Compounds
- Hydrogels: synthesis, properties, applications
- Cloud Data Security Solutions
- Fault Detection and Control Systems
- Cancer Research and Treatments
- Topic Modeling
- Gamma-ray bursts and supernovae
- Particle Detector Development and Performance
- Silk-based biomaterials and applications
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
Peking University
2025
National University of Singapore
2025
China University of Mining and Technology
2022-2024
The Lobster Eye Imager for Astronomy (LEIA), a pathfinder of the Wide-field X-ray Telescope Einstein Probe (EP) mission, was successfully launched onboard SATech-01 satellite Chinese Academy Sciences on 27 July 2022. In this paper, we introduce design and on-ground test results LEIA instrument. Using state-of-the-art Micro-Pore Optics (MPO), wide field-of-view (FoV) 346 square degrees (18.6 * 18.6 degrees) imager is realized. An optical assembly composed 36 MPO chips used to focus incident...
Immune checkpoint inhibitors (ICI) have transformed cancer treatment. However, only a minority of patients achieve profound response. Many are innately resistant while others acquire resistance to ICIs. Furthermore, hepatotoxicity and suboptimal efficacy hampered the clinical development agonists 4-1BB, promising immune-stimulating target. To effectively target 4-1BB treat diseases ICIs, we engineered ATG-101, tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. ATG-101 bound PD-L1...
The accuracy and integrity of structural deformation monitoring can be improved by the GNSS/accelerometer integrated system, gross error detection is key to further improving reliability monitoring. Traditional methods assume that real-state information known, they need establish state iterators, which leads low computational efficiency. Meanwhile, in multi-sensor fusion, if sampling rates are different, change dimension observation matrix must considered, calculation complex. Based on...
The BDS multipath delay error is highly related to the surrounding monitoring environment, which cannot be eliminated or mitigated by applying double difference observation model. In actual due complexity of constellation, it difficult for existing algorithms consider GEO, IGSO, MEO and other different orbital types satellites real-time efficient reduction. Therefore, we propose a novel dual-frequency reduction method real deformation considering various satellite orbit types. This extracts...
Abstract The BDS multipath delay error is highly related to the surrounding monitoring environment, which cannot be eliminated or mitigated by establishing double difference observation model. In actual due complexity of constellation, it difficult for existing algorithms consider GEO, IGSO, MEO and other different orbital types satellites real-time efficient reduction. Therefore, this paper proposes a novel dual-frequency reduction method real deformation considering various satellite orbit...
Abstract Background: Acute myeloid leukemia (AML) is the most common acute in adults, and treatment of AML, especially monocytic AML subtypes still has a poor outcome. T cell engagers (TCE) have been well used for hematological malignancies, such as B multiple myeloma. However, lack ideal target antigens that only express on leukemic stem cells (LSCs) but not normal hematopoietic (HSCs) hampers development TCE therapy AML. Leukocyte immunoglobulin-like receptor B4 (LILRB4), an inhibitory...
Abstract Background: CD3+ T cell engaging bispecific antibodies (TCE) redirect cells to attack targeted tumor by simultaneously binding TAA on cancer and CD3 complex a form TCR-independent immune synapse. Multiple TCEs have demonstrated promising therapeutic efficacy in the treatment of hematological malignancies. In contrast, suboptimal solid tumors risk inducing cytokine release syndrome (CRS) continue be major challenges. Several factors, such as format, affinity, valency antibody, copy...
<div>Abstract<p>Immune checkpoint inhibitors (ICI) have transformed cancer treatment. However, only a minority of patients achieve profound response. Many are innately resistant while others acquire resistance to ICIs. Furthermore, hepatotoxicity and suboptimal efficacy hampered the clinical development agonists 4-1BB, promising immune-stimulating target. To effectively target 4-1BB treat diseases ICIs, we engineered ATG-101, tetravalent "2+2″ PD-L1×4-1BB bispecific antibody....
<div>Abstract<p>Immune checkpoint inhibitors (ICI) have transformed cancer treatment. However, only a minority of patients achieve profound response. Many are innately resistant while others acquire resistance to ICIs. Furthermore, hepatotoxicity and suboptimal efficacy hampered the clinical development agonists 4-1BB, promising immune-stimulating target. To effectively target 4-1BB treat diseases ICIs, we engineered ATG-101, tetravalent "2+2″ PD-L1×4-1BB bispecific antibody....
<p>Supplementary Methods, Supplementary Figures and Table S1-2</p>
<p>Supplementary Methods, Supplementary Figures and Table S1-2</p>
Owing to the unprecedented capability in semantic understanding and logical reasoning, pre-trained large language models (LLMs) have shown fantastic potential developing next-generation recommender systems (RSs). However, static index paradigm adopted by current methods greatly restricts utilization of LLMs capacity for recommendation, leading not only insufficient alignment between collaborative knowledge, but also neglect high-order user-item interaction patterns. In this paper, we propose...