A5100752045- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis B Virus Studies
- Neurological Disorders and Treatments
- Hepatitis C virus research
- Medicinal Plants and Neuroprotection
- Ginkgo biloba and Cashew Applications
- Botulinum Toxin and Related Neurological Disorders
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Oral Health Pathology and Treatment
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Hepatitis Viruses Studies and Epidemiology
- Amyotrophic Lateral Sclerosis Research
- Traditional Chinese Medicine Studies
- Oral and gingival health research
- Neurogenesis and neuroplasticity mechanisms
- Biological and pharmacological studies of plants
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2016-2025
Shanxi Medical University
2015-2025
Jining First People's Hospital
2025
Qinghai University Affiliated Hospital
2025
Qinghai University
2025
Johns Hopkins Medicine
2025
Johns Hopkins University
2025
Yunnan University of Traditional Chinese Medicine
2023-2025
Yunnan Provincial Hospital of Traditional Chinese Medicine
2023-2025
Technical University of Munich
2024
Smoking is a well-established risk factor for kidney cancer. Analyzing the latest global spatio-temporal trends in cancer burden attributable to smoking critical informing effective public health policies. Using data from 2021 GBD database, we examined deaths, disability-adjusted life years (DALYs), and age-standardized rate (ASR) of across global, regional, national levels. Trends ASRs were assessed through estimated annual percentage change (EAPC). We conducted cross-country analysis...
Background/Objectives The Trail‐Making Test ( TMT ), which is commonly used to measure executive function, consists of two components ‐A and TMTB ). There a lack normative data for Chinese elderly adults. This study aimed evaluate the validity in screening cognitive impairment. Design 2,294 Chinese‐speaking adults aged 50 85: 1,026 with normal cognition NC 462 mild impairment MCI 108 Alzheimer's disease AD 113 vascular (Va 121 dementia (VaD), 282 uncertain types dementia, 15 mixed dementia....
The present study focused on the action mechanism of S. pneumoniae (Sp) in inducing autophagy human alveolar epithelial cells. Sp, a gram-positive extracellular bacterium, activates with considerably increased microtuble-associated protein light chain 3 (LC3) punctation A549 accumulation typical autophagosomes and conjugation LC3 to phosphatidylethanolamine were observed Sp-infected cells as an indication autophagy. Using pneumolysin (PLY) mutant, we successfully demonstrated that PLY is...
Evidence suggests that curcumin, the phytochemical agent in spice turmeric, might be a potential therapy for Alzheimer's disease (AD). Its antioxidant, anti‐inflammatory properties have been investigated extensively. Studies also shown curcumin can reduce amyloid pathology AD. The underlying mechanism, however, is complex and still being explored. In this study, we used APPswe/PS1dE9 double transgenic mice, an AD model, to investigate effects mechanisms of prevention treatment water maze...
Abstract Background The Hopkins Verbal Learning Test (HVLT) has been validated for detecting dementia in English-speaking populations. However, no studies have examined the Chinese version of HVLT scale, and appropriate cut-off scores population remain unclear. Methods 631 subjects aged 60 over were recruited at a memory clinic Dongzhimen Hospital Beijing. Of these, 249 classified as exhibiting normal cognition (NC), 134 diagnosed with mild cognitive impairment (MCI), 97 Alzheimer’s disease...
Pathological relationships between damage to the deep white matter of cerebral cortex [as evidenced by myelin loss (ML)], amyloid angiopathy (CAA) and arteriosclerosis (ART) were investigated in brains 137 patients with autopsy‐confirmed Alzheimer's disease (AD), order better understand causes AD, contribution this pathogenesis disorder. All had some degree CAA one or more brain regions although occipital was severely affected frequently, consequently mean severity score significantly...
Recent studies have shown the therapeutic potential of curcumin in Alzheimer's disease (AD). In 2014, our lab found that reduced Aβ40, Aβ42 and Aβ-derived diffusible ligands mouse hippocampus, improved learning memory. However, mechanisms underlying this biological effect are only partially known. There is considerable evidence brain metabolism indicating AD might be a brain-specific type diabetes with progressive impairment glucose utilisation insulin signalling. We hypothesised target both...
Conventional therapy (CT) such as donepezil and memantine are well-known short-term treatments for the symptoms of Alzheimer's disease (AD). The efficacy them, however, drops below baseline level after 9 months. In China, herbal a complementary is very popular. Should conventional combined with (CT + H) make add-on benefit? this retrospective cohort study, 344 outpatients diagnosed probable dementia due to AD were collected, treatment either CT H or alone in clinical settings. All patients...
The aim of this study was to assess the serum zinc levels in patients with common oral mucosal diseases by comparing these healthy controls.A total 368 patients, which consisted 156 recurrent aphthous stomatitis (RAS) 57 lichen planus (OLP) 55 burning mouth syndrome (BMS) 54 atrophic glossitis (AG) 46 xerostomia and 115 sex-and age-matched control subjects were enrolled study. Serum measured all participants. Statistical analysis performed using a one-way ANOVA, t-test, Chi-square test.The...
Significant losses of synapses have been demonstrated in studies Alzheimer's disease (AD), but structural and functional changes that depend on alterations the postsynaptic density (PSD) area occur prior to synaptic loss play a crucial role pathology AD. Evidence suggests curcumin can ameliorate learning memory deficits To investigate effects synapses, APPswe/PS1dE9 double transgenic mice (an AD model) were used, ultra-structures synapse-associated proteins observed. Six months after...
It has been suggested that patients with motor neurone disease (MND) and those MND combined behavioural variant frontotemporal dementia (bvFTD) (ie FTD + MND) or alone might exist on a continuum based commonalities of neuropathology and/or genetic risk. Moreover, it reported both neuronal glial cell tauopathy can accompany the TDP-43 proteinopathy in cognitive changes, may be fundamental to pathogenesis clinical phenotype. In present study, we sought substantiate these latter findings, test...
Abstract Hyperoxaluria‐induced calcium oxalate (CaOx) deposition is the key factor in kidney stone formation, for which adipose‐derived stromal cells (ADSCs) have been used as a therapeutic treatment. Studies revealed that miR‐20b‐3p down‐regulated hypercalciuric stone‐forming rat kidney. To investigate whether ADSC‐derived miR‐20b‐3p‐enriched exosomes protect against stones, an ethylene glycol (EG)‐induced hyperoxaluria model and vitro of oxalate‐induced NRK‐52E were established to explore...