A5054086672- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Regulation of Appetite and Obesity
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- Trace Elements in Health
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Risks and Factors
- Microtubule and mitosis dynamics
- Adipose Tissue and Metabolism
- Glycosylation and Glycoproteins Research
Shanxi Medical University
2016-2025
Shanxi Provincial Cancer Hospital
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2013
Wuxi Fourth People's Hospital
2010
Shanxi University of Traditional Chinese Medicine
2008
Cancer Institute (WIA)
1997-2008
First Affiliated Hospital of Chengdu Medical College
2001
To evaluate the value of combined detection serum CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS for clinical diagnosis upper gastrointestinal tract (GIT) cancer to analyze efficacy these tumor markers (TMs) in evaluating curative effects prognosis. A total 573 patients with GIT between January 2004 December 2007 were enrolled this study. Serum levels examined preoperatively every 3 months postoperatively by ELISA. The sensitivity 26.8%, 36.2%, 42.9%, 2.84%, 25.4%, 34.6%, 34.2% 30.9%,...
Aim To investigate the relationship between serum levels of CEA, CA19-9, CA24-2, CA72-4, and AFP in patients with gastric cancer (GC) their clinicopathological characteristics; to analyze efficacy these tumor markers evaluating prognosis GC. Methods Overall, 389 GC either located cardia (132), pyloric antrum (112) or body stomach (145) were included study. Serum detected ECLIA method, while CA24-2 was measured ELISA. Results First, level CEA a cardia-located significantly higher than...
AIM:To investigate the roles of serum insulin, insulinlike growth factor-1 (IGF-1), and insulin-like factor binding proteins (IGFBPs) in initiation progression colorectal cancer. METHODS:We determined IGF-1 IGFBPs levels 615 cancer patients 650 control healthy donors by enzyme-linked immunosorbent assay (ELISA).In meantime, their body mass index (BMI) waist-to-hip ratio (WHR) were measured. RESULTS:Serum insulin as well IGF-1/IGFBP-3 pre-operation significantly elevated, but level IGFBP-3...
The aim of this study was to explore the predictive role inflammation-related parameters in prognosis esophageal squamous cell carcinoma (ESCC).A total 370 ESCC patients subjected curative surgery were enrolled. All had complete medical records and did not receive preoperative adjuvant therapy. Preoperative systemic immune-inflammation index (SII) calculated as platelet count × neutrophil count/lymphocyte count, prognostic nutrition (PNI) albumin concentration (g/L) + 5 lymphocyte (109/L),...
Effective screening and treatment have reduced the number of women dying from breast cancer (BC). However, long-term sequelae BC psychosocial factors seriously affect life quality patients survivors. Therefore, discovery application targeted biomarkers to improve functional outcome is necessary.To explore impact leptin (LEP)/ receptor (LEPR) expression on occurrence survival BC.Totally 132 primary 66 non-BC who underwent surgery in department Shanxi Cancer Hospital January October 2009 were...
Keratin 19 (KRT19) is a type I cytokeratin that serves an important role in multiple types of cancer; however, little known regarding its thyroid cancer. Therefore, the aim current study was to investigate KRT19 Using The Cancer Genome Atlas database, expression and clinical significance cancer tissues were investigated. effect cell lines also investigated vitro. results demonstrated higher when compared with normal tissues, associated lymph node metastasis, tumor stage tumor-node-metastasis...
Abstract Objective To explore the clinical significance of expression CEA mRNA and serum related proteins in colorectal cancer (CRC). Methods Blood samples were collected from 370 CRC patients 350 controls. was determined by RT‐PCR levels CEA, CA19‐9, CA242, CA724 examined with chemiluminescence. Results The positive rate jointly detecting significantly higher than expressions ( P < 0.01), both rates correlated TNM stage, lymph node, visceral metastasis. poorly differentiated tumor that...
We investigated the relationship between urokinase type plasminogen activator receptor (uPAR) in sera and tissues of patients with cervical cancer clinical pathological features cancer. Immunohistochemistry (SABC method) was used to detect uPAR expression normal tissues; ELISA employed assay levels corresponding sera. The immunohistochemistry results showed that there were 37 cases 56 a positive rate 66%, whereas no tissues. tissue from (70.92 ± 28.55 ng/100 mg protein) significantly higher...
Abstract Objective Tumor-specific growth factor (TSGF) is an immune-related that offers good performance in the clinical management of human cancers. However, role serum TSGF esophageal squamous cell carcinoma (ESCC) has not been fully clarified. Methods A total 562 ESCC cases were collected our study, with available information on preoperative levels at diagnosis. Preoperative was detected using rate method. We retrospectively analyzed its correlation clinicopathological features and...
Background To explore the relationship of serum squamous cell carcinoma antigen ( SCC ‐Ag) with pathologic characteristics, occurrence, and prognosis cervical carcinoma. Methods The enzyme‐linked immunosorbent assay ELISA ) method was used to determine ‐Ag levels for patients, which included 424 pretreatment patients 500 cases after treatment. Results (a) Pretreatment were related clinical stages, lymphatic metastasis, myometrial invasion, (b) within a median follow‐up 54 months, 180...
In the era of immunotherapy, immune function patients with cancer has attracted increasingly more attention. The scoring system is an important supplement to classical tumor staging and classification process. plays a controversial role in development cancer. Meanwhile, prognostic significance peripheral blood lymphocytes still controversial. present study aimed assess eight types cancers.We performed retrospective analysis 32731 hospitalized Shanxi Cancer Hospital from January 2012 December...
This study aims to understand the clinical features, treatment, and prognosis of patients with male breast cancer (MBC) in Shanxi province China from 2007 2016. Data for 77 MBC were collected analysis. Immunohistochemistry, pathological results, other data such as demographic characteristics (age, marital status, smoking history, drinking family history cancer) well investigated by retrieving information patients' medical records. A total 12,404 diagnosed between 2016, among them. The median...
To explore the clinical utility of tumor-specific growth factor (TSGF) and soluble interleukin-2 (IL-2) receptor (sIL-2R) as immune-related factors for predicting lymph node metastases (LNM) papillary thyroid carcinoma (PTC).A total 206 patients with PTC subjected to curative surgery were enrolled. All had complete medical records. Serum levels TSGF detected using Automatic Biochemistry Analyzer serum sIL-2R concentration was by enzyme-linked immunosorbent assay (ELISA). Furthermore, we...