A5101498030- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer, Hypoxia, and Metabolism
- Bioactive Natural Diterpenoids Research
- Angiogenesis and VEGF in Cancer
- PI3K/AKT/mTOR signaling in cancer
- Flavonoids in Medical Research
- Plant biochemistry and biosynthesis
- Ginseng Biological Effects and Applications
- Plant Gene Expression Analysis
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Garlic and Onion Studies
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Bioactive natural compounds
- Protease and Inhibitor Mechanisms
- Ion Channels and Receptors
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Phytochemical compounds biological activities
- Genetic diversity and population structure
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
Zigong First People's Hospital
2023-2025
Zhejiang Sci-Tech University
2024-2025
Zhejiang Institute of Modern Textile Industry
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Ningbo University of Technology
2025
Tokyo University of Agriculture and Technology
2024-2025
Nanjing University of Chinese Medicine
2015-2024
Kunming Medical University
2024
Fujian Agriculture and Forestry University
2024
Cadmium (Cd), a toxic environmental contaminant, induces oxidative stress, leading to neurodegenerative disorders. Recently we have demonstrated that Cd neuronal apoptosis in part by activation of the mitogen-activated protein kineses (MAPK) and mammalian target rapamycin (mTOR) pathways. However, underlying mechanism remains elusive. Here show elevated intracellular calcium ion ([Ca2+]i) level PC12, SH-SY5Y cells primary murine neurons. BAPTA/AM, an Ca2+ chelator, abolished Cd-induced...
The mammalian target of rapamycin (mTOR) functions in cells at least as two complexes, mTORC1 and mTORC2. Intensive studies have focused on the roles mTOR regulation cell proliferation, growth, survival. Recently we found that inhibits type I insulin-like growth factor (IGF-1)-stimulated lamellipodia formation motility, indicating involvement regulating motility. This study was set to further elucidate underlying mechanism. Here show inhibited protein synthesis activities small GTPases...
Background Migration and invasion are two crucial steps of tumor metastasis. Blockage these may be an effective strategy to reduce the risk. The objective present study was investigate effects diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying anticancer DATS were further investigated. Methods Results MDA-MB-231 cells HS 578t treated different...
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism endothelial cells emerges as a promising option achieve vascular normalization antagonize progression. Herein, we demonstrated that salvianic acid A (SAA) played pivotal role in contributing tumor-bearing mice, thereby improving delivery effectiveness chemotherapeutic agent. SAA was capable inhibiting glycolysis strengthening junctions human umbilical vein (HUVECs) exposed...
Abstract Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA‐MB‐231 xenografts. To unveil underlying mechanism, further studied antitumor activity cell culture. The results indicate proliferation induced apoptosis rhabdomyosarcoma (Rh30), carcinoma (MDA‐MB231) colon adenocarcinoma (HT‐29) cells concentration‐dependent manner. By cycle analysis, accumulation G...
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is potential anticancer agent. However, little known about its mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G(1)-G(0) phase of cycle. This associated with inhibition cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, found signaling pathway mammalian target rapamycin (mTOR), central regulator proliferation. evidenced...
Intratumoral hypoxia promotes the distant metastasis of cancer subclones. The clinical expression level hypoxia‐inducible factor‐1α (HIF‐1α) reflects prognosis a variety cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF‐1α protein due to von Hippel‐Lindau (VHL) protein‐dependent degradation. Dietary organosulfur compounds, such as those in garlic, have been reported HDAC inhibitors. effects diallyl sulfide (DAS), disulfide (DADS), and trisulfide (DATS)...
Pyruvate kinase M2 (PKM2), playing a central role in regulating aerobic glycolysis, was considered as promising target for cancer therapy. However, its metastasis is rarely known. Here, we found tight relationship between PKM2 and breast metastasis, demonstrated by the findings that beta-elemene (β-elemene), an approved drug complementary therapy, exerted distinct anti-metastatic activity dependent on PKM2. The results indicated β-elemene inhibited cell migration, invasion vitro well...
Abstract Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is potential anticancer agent. However, underlying mechanism not well understood. Here, we show that CPT induced caspase-independent cell death in human tumor cells (Rh30, DU145, and MCF-7). Besides downregulating antiapoptotic protein expression of survivin Mcl-1, increased phosphorylation p38 mitogen-activated kinase (MAPK) c-jun N-terminal (JNK), inhibited extracellular signal–regulated...
Curcumin can induce p53-independent apoptosis. However, the underlying mechanism remains to be defined. Here, we show that curcumin-induced apoptosis in a panel of tumor cells with mutant p53. rapidly induced activation mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal (JNK). Inhibition JNK (with SP600125) or Erk1/2 U0126) partially prevented cell death cells. Similarly, expression dominant negative downregulation part...
Mammalian target of rapamycin (mTOR) controls lymphangiogenesis. However, the underlying mechanism is not clear. Here we show that suppressed insulin-like growth factor 1 (IGF-1)- or fetal bovine serum (FBS)-stimulated lymphatic endothelial cell (LEC) tube formation, an in vitro model Expression a rapamycin-resistant and kinase-active mTOR (S2035T, mTOR-T), but kinase-dead (S2035T/D2357E, mTOR-TE), conferred resistance to inhibition LEC suggesting formation kinase activity dependent. Also,...
Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese medicine Glycyrrhiza uralensis Fisch. Although the protective effects MgIG on methotrexate (MTX)-induced liver toxicity have well-documented, underlying mechanism remains elusive. MTX was initially used pediatric acute leukemia, and applied psoriasis therapy. However, its clinical applications are limited due...
Background/Aims: Metastasis is the leading cause resulting in high mortality triple negative breast cancer (TNBC) patients. Cancer cells are skilled at utilizing thioredoxin (Trx) system as an efficient antioxidant to counteract oxidative damage, facilitating occurrence of metastasis. Here, we identified organosulfur compound named DATS isolated from garlic, that inhibits expression Trx-1 and enzyme activity Trx reductase cells. Methods: Tissue microarray patients immunohistochemical method...
Mammalian target of rapamycin (mTOR) serves an important role in regulating various biological processes, including cell proliferation, metabolism, apoptosis and autophagy. Among these energy metabolism is the dominant process. The not only amino acids, fatty acids lipids, but also that nucleotides glucose has been indicated to be regulated by mTOR. Aerobic glycolysis, which a specific form prevalent carcinomas, it considered potential for cancer therapy. In reviewing complexity mTOR...
Abstract Background Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of IIA in regulating stemness tumor cells remain unclear. This work aims to explore underlying mechanisms breast cancer stemness. Methods In vitro mammary spheroid formation, flow cytometry assay on CD24 − /CD44 + sub-population, ALDH activity detection, cell viability western blot analysis, vivo tumor-initiating analysis were performed examine effects cells. MiRNAs-based...
As global demand for sustainable biomass and need to mitigate warming begin rise, cultivation of seaweed has gained significant attention in recent years due its potential carbon recycling. However, limited availability suitable coastal areas large-scale led exploration offshore environments as a viable alternative. The nature many often exposes farming systems harsh environmental conditions, including strong waves, currents, wind. These factors can lead structural failures, kelp losses,...