A5100349634- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional Chinese Medicine Studies
- Natural Compounds in Disease Treatment
- Acupuncture Treatment Research Studies
- Flavonoids in Medical Research
- Bioactive Natural Diterpenoids Research
- Medical Research and Treatments
- Healthcare and Venom Research
- Andrographolide Research and Applications
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Phytochemical and Pharmacological Studies
- Neurological Disease Mechanisms and Treatments
- Cell death mechanisms and regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Medicinal Plant Pharmacodynamics Research
- Metabolomics and Mass Spectrometry Studies
- Sepsis Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Fibroblast Growth Factor Research
- Cardiac Arrest and Resuscitation
- Medicinal plant effects and applications
Shaoxing People's Hospital
2021-2025
China University of Petroleum, East China
2024
Xihua University
2024
Hainan Medical University
2024
Second Hospital of Shandong University
2024
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
First Affiliated Hospital of GuangXi Medical University
2015-2022
Guangxi Medical University
2015-2022
Yangzhou University
2022
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is potential anticancer agent. However, little known about its mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G(1)-G(0) phase of cycle. This associated with inhibition cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, found signaling pathway mammalian target rapamycin (mTOR), central regulator proliferation. evidenced...
Hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth (VEGF) play important roles in angiogenesis tumor growth. Tanshinone IIA (T2A) is a novel antiangiogenic agent with promising antitumor effects; however, the molecular mechanism underlying effects of T2A remains unclear. In present study, we provided evidence showing that inhibited breast cancer by down-regulating VEGF expression. Specifically, repressed HIF-1α expression at translational level transcriptional activity...
Abstract Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is potential anticancer agent. However, underlying mechanism not well understood. Here, we show that CPT induced caspase-independent cell death in human tumor cells (Rh30, DU145, and MCF-7). Besides downregulating antiapoptotic protein expression of survivin Mcl-1, increased phosphorylation p38 mitogen-activated kinase (MAPK) c-jun N-terminal (JNK), inhibited extracellular signal–regulated...
Astragalus mongholicus (MG) and membranaceus (MJ), both generally known as Huangqi in China, are two perennial herbals widely used variety diseases. However, there were still some differences the chemical ingredients between MG MJ. In this paper, metabolomics combined with ultra-high performance liquid chromatography coupled electrospray ionization/quadrupole time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF-MS/MS) was employed to contrastively analyze constituents As a result, principal...
Cadmium (Cd), an environmental and industrial pollutant, affects the nervous system consequential neurodegenerative disorders. Recently, we have shown that celastrol prevents Cd-induced neuronal cell death partially by suppressing Akt/mTOR pathway. However, underlying mechanism remains to be elucidated. Here, show attenuated Cd-elevated intracellular-free calcium ([Ca2+ ]i ) level apoptosis in cells. Celastrol prevented inhibiting Akt-mediated mTOR pathway, as inhibition of Akt with...
Flavonoids have attracted considerable attention due to their health benefits. This study aimed investigate the flavonoid profiles and antioxidant activity of Paeonia lactiflora petal extract (PPF). The UHPLC-ESI-Q-Exactive HF MS/MS method was established for characterization, 21 predominant compounds were tentatively identified in PPF. Among them, isoscutellarein-7-(6'-acetylallosyl-(1->2)-glucoside) scutellarin methylester discovered PPF first time. Pretreatment with significantly reduced...
Ampelopsin (APL), a major bioactive constituent of Ampelopsis grossedentata, exerts number biological effects. Here, we explored the anti-diabetic activity APL and elucidate underlying mechanism this action. In palmitate-induced insulin resistance L6 myotubes, treatment markedly up- regulated phosphorylated receptor substrate-1 protein kinase B, along with corresponding increase glucose uptake capacity. also increased expressions fibroblast growth factor (FGF21) adenosine 5'-monophosphate...
Aberrant activation of the Wnt/β-catenin pathway contributes to development diabetic nephropathy (DN); however, treatment with Tripterygium wilfordii (TW) may be beneficial for patients DN. The aim present study was evaluate effect TW on Wnt/β‑catenin expression in kidneys rats. Male Sprague‑Dawley rats were randomly injected vehicle (control) or streptozotocin induce diabetes. Diabetic then treated (sodium carboxymethyl cellulose; SCC), combined SCC (8 16 mg/kg) irbesartan (50 daily 8...
As the main active constituent of Andrographis paniculata that was applied in treatment many diseases including inflammation ancient China, andrographolide (ANDRO) found to facilitate reduction edema and analgesia arthritis. This suggested ANDRO may be promising anti-inflammatory agent relieve destruction degeneration cartilage after inflammation. In this study, effect on rabbit articular chondrocytes vitro investigated. Results showed not more than 8 μ M did no harm (<mml:math...
Triptolide (TP), a diterpenoid triepoxide purified from the Chinese traditional medicine Tripterygium wilfordii Hook F (TWHF), possesses potent anti-tumor activities against several malignancies, including ovarian cancer. However, its short half-life in circulation and severe reproductive toxicity prohibit clinical use of TP. In this study, we engineered novel nanoparticles consisting calcium phosphate conjugated TP-loaded liposomes (TP@Lips-Ca/P), constituted mPEGDPPE2000, to improve time,...
Tripterygium is a Chinese herb with immunosuppressive effects and an established history of use in the treatment rheumatoid arthritis. Previous studies demonstrated that tripterygium glycosides (TPG) alleviated Freund's complete adjuvant (FCA)-induced Simultaneously, it has also been observed to impact arthritis (AA) associated lung injury. In this study, we have investigated whether traditional medicine could attenuate injury induced by AA observing TPG on degree swelling, index (AI), (LI),...
To verify the effect of warm acupuncture combined with western medicine in patients acute exacerbation chronic obstructive pulmonary disease (AECOPD) phlegm-turbid obstructing lung.Ninety AECOPD were randomly divided into a group, group and sham 30 cases each group. Routine treatment according to Global initiative for lung (GOLD) guidelines was used On basis routine treatment, applied at Fenglong (ST 40), Feishu (BL 13), Zusanli 36) other acupoints In non-acupoints taken on conventional...
We evaluated the effects of electroacupuncture (EA) at Neiguan and Ximen on prognosis patients with stable ischemic heart disease. A total 240 symptomatic suspected coronary artery disease referred for angiography were analyzed, 232 (62.3 ± 9.1 years) included. The primary end point was major adverse cardiovascular events (MACEs), defined as a composite recurrent angina requiring hospitalization, nonfatal acute myocardial infarction, cardiogenic death, death from any other causes. Over mean...