A5102872818- Alzheimer's disease research and treatments
- Molecular Junctions and Nanostructures
- Prion Diseases and Protein Misfolding
- Ubiquitin and proteasome pathways
- Trace Elements in Health
- Advanced biosensing and bioanalysis techniques
- Remote Sensing in Agriculture
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Endoplasmic Reticulum Stress and Disease
- Advanced Chemical Sensor Technologies
- Graphene research and applications
- RNA modifications and cancer
- Advanced X-ray and CT Imaging
- Ion channel regulation and function
- Metal-Catalyzed Oxygenation Mechanisms
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Metal complexes synthesis and properties
- Nanowire Synthesis and Applications
- Receptor Mechanisms and Signaling
- Advanced Fluorescence Microscopy Techniques
Nankai University
2022-2025
Xiangya Hospital Central South University
2021-2024
Central South University
2011-2024
Zhejiang University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Qingdao University
2019-2024
Renmin University of China
2013-2023
Beijing Chest Hospital
2022
Capital Medical University
2022
Peking University
2006-2022
Background: Volatile organic compounds (VOCs) biomarkers in breath provide a novel, noninvasive and quick approach to diagnosis lung cancer. The aim of the proposed study was investigate VOCs exhaled for Metho
The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream signaling, is unclear. To determine Jmjd3 during mesoderm and cardiovascular lineage commitment. Ablation mouse embryonic stem cells does not affect maintenance pluripotency self-renewal but compromised subsequent endothelial cardiac differentiation. reduces H3K27me3 marks Brachyury promoter facilitates recruitment β-catenin, which critical for Wnt...
The fingerprinting location method is commonly used in WLAN indoor positioning system. Device diversity (DD) which leads to Received Signal Strength (RSS) value difference between the users' device and reference becoming an increasingly important factor impacting accuracy. Thus, a key problem gained more attention system recently, introduces many uncertainties result. Traditionally, Euclidean distance widely adopted method. However, when encountering with RSS caused by diversity,...
By effectively observing the land surface and obtaining farmland conditions, satellite remote sensing has played an essential role in agricultural drought monitoring over past decades. Among all techniques, optical thermal have most extended history of being utilized monitoring. The primary goal this paper is to illustrate how been will be applied monitoring, assessment, prediction drought. We group methods into four categories: optical, thermal, multi-source. For each category, a concise...
Inhibition of human amylin fibril formation by insulin-mimetic vanadium complexes.
The mechanisms of self-renewal and pluripotency maintenance human pluripotent stem cells (hPSCs) have not been fully elucidated, especially for the role those poorly characterized long noncoding RNAs (lncRNAs).ESRG is a lncRNA highly expressed in hPSCs, its functional roles are being extensively explored field.Here, we identified that transcription ESRG can be directly regulated by OCT4, key factor hPSCs.Knockdown induces hPSC differentiation, cell cycle arrest, apoptosis.ESRG binds to MCM2,...
Cytochrome P450 2E1 (CYP2E1) converts isoniazid (INH) to toxic metabolites and is critical in INH-induced liver injury. The aim investigate the effect of folic acid (FA) on CYP2E1 Male Balb/c mice were used. control group only received an AIN-93M diet. diet was supplemented with 0.66 g INH/kg for INH FA groups. treated additional 0.01 FA/kg one-carbon cycle metabolites, expressions DNA RNA methylation levels detected reveal potential mechanism. treatment significantly reduced alanine...
Detecting chemical reaction dynamics at solid-liquid interfaces is important for understanding heterogeneous reactions. However, there a lack of exploration interface from the single-molecule perspective, which can reveal intrinsic mechanism underlying ensemble experiments. Here, single-event protonation are studied in-situ using junctions. Molecules with amino terminal groups used to construct An interfacial cationic state present after discovered. Real-time electrical measurements monitor...
Lung cancer (LC) is the leading cause of cancer-related death. The sensitive and non-invasive diagnostic tools in early stage are still poor. We present a pilot study on diagnosis LC by detecting markers exhaled breath condensate (EBC). EBC samples were collected from 105 patients with 56 healthy controls. applied chemiluminescence immunoassay to detect CEA (carcinoembryonic antigen), SCC (squamous cell carcinoma) antigen NSE (neuron specific enolase) serum. Concentrations compared between...
Human islet amyloid polypeptide (hIAPP) can be linked to the pathology of type II diabetes. In this study, aromatic ring-containing Ru complexes were found effectively inhibit fibril formation hIAPP and promote disaggregation formed fibrils by remarkably changing β-sheet components.
The misfolding and aggregation of human islet amyloid polypeptide (hIAPP) amyloid-β (Aβ) protein are closely associated with type 2 diabetes mellitus (T2DM) Alzheimer's disease, respectively. Inhibitors peptides include short peptides, aromatic organic molecules, nanoparticles, even metal compounds. Sesquiterpenoid artemisinins widely used in anti-malaria treatments, they may modulate glucose homeostasis against diabetes. However, the antidiabetic mechanism these compounds remains unclear....
Peroxovanadium complexes inhibit the fibril formation of neurodegenerative amyloid peptides by oxidizing methionine residues.
Abstract Myofibrillogenesis regulator‐1 (MR‐1) is a multifunctional protein involved in the development of various human tumors. The study first to report promoting effect MR‐1 on and metastasis non‐small cell lung cancer (NSCLC). upregulated NSCLC positively associated with poor prognosis. overexpression promotes cells by stabilizing expression Notch3‐ICD (NICD3) cytoplasm through enrichment analysis, vitro vivo experimental researches. And Notch3 signaling can upregulate many genes related...