A5100383839- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pluripotent Stem Cells Research
- Advanced Glycation End Products research
- HER2/EGFR in Cancer Research
- Immune Response and Inflammation
- Protease and Inhibitor Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Science, Research, and Medicine
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Bone and Joint Diseases
- Cancer Mechanisms and Therapy
- Barrier Structure and Function Studies
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromatography in Natural Products
- Flavonoids in Medical Research
Nanfang Hospital
2024
OriginWater (China)
2024
Shantou University
2019-2023
Shantou University Medical College
2019-2023
Northwest University
2023
Xi'an University of Technology
2023
Xinjiang University
2023
First Hospital of Xi'an
2023
First Hospital of Qinhuangdao
2023
Third Affiliated Hospital of Southern Medical University
2021-2022
Background: High-mobility group box 1 protein (HMGB1) was identified as a highly conserved DNA binding nuclear protein, which participates in the processes of acute lung injury (ALI). HMGB1 binds to its specific receptors not only activate factor (NF)-κB and mitogen-activated kinase (MAPK) pathways but also regulate activation phosphatidylinositol 3′-kinase/protein B/mammalian target rapamycin (PI3K/AKT/mTOR) pathway. Mature dendritic cells (DCs) inflammation pathological ALI. In addition,...
Background: Cerebral oedema leading to cerebral herniation is a major cause of death during acute liver failure (ALF), but the underlying mechanism not clear. Aims: We investigated role tumour necrosis factor (TNF)-α in changing permeability blood–brain barrier (BBB) ALF. Methods: ALF animal models were generated by administering d-galactosamine (GalN) and lipopolysaccharide, or GalN TNF-α. induction was blocked first anti-TNF-α–IgG anti-TNF-α-R1. BBB with Evans blue staining, structure...
Abstract CD8 + T cells play a central role in antitumour immunity, which often exhibit ‘exhaustion’ the setting of malignancy and chronic viral infection due to cell immunoglobulin mucin domain 3 (TIM3) myeloid‐derived suppressor (MDSCs). Our team previously found that overactive MDSCs exhausted TIM3 were observed myelodysplastic syndromes (MDS) patients. However, it is not obvious whether suppress through TIM3/Gal‐9 pathway. Here, Gal‐9, as ligand TIM3, was overexpressed MDSCs. The levels...
Alcohol consumption is regarded as one of the leading risk factors for secondary osteopenia. Coupled angiogenesis and osteogenesis via distinct type-H vessels orchestrates subtle biological processes bone homeostasis. The dysfunction contributes to decreased mass during development Herein, we identified microRNA-136-3p was remarkedly downregulated in mouse model alcohol-induced Following alcohol administration, significantly suppressed vascularization osteogenic differentiation human...
Recently, numerous studies have demonstrated the emerging role of long non-coding RNAs (lncRNAs) in human cancers. Linc00467 is a newly defined lncRNA and was reported to promote cell survival neuroblastoma. However, function linc00467 lung cancer still unclear.We analyzed expression data derived from The Cancer Genome Altas adenocarcinoma (LUAD) dataset as well collected LUAD tissues. Then, we silenced two lines using small interfering explored effect knockdown on growth vitro vivo....
Objective To investigate the synergistic effects of cryptotanshinone (CPT) and doxorubicin (DOXO) on induction apoptosis in human gastric cancer cells mechanisms. Methods Cell proliferation were detected using CCK8 assay AnnexinV/PI staining, respectively. Western blotting was used to determine levels phosphorylation proteins encoded by STAT3-regulated genes cleaved forms caspases PARP. Results CPT significantly potentiated antiproliferative effect DOXO cell lines. combined with induced...
Background: MiR-1323 was identified in 2006. Until now, the roles and mechanisms of miR-1323 progression cancers including hepatocellular carcinoma (HCC) remain unknown. The aim this study to investigate expressions, HCC development. Methods: QRT-PCR used evaluate expressions miR-1323, GAS5 TP53INP1 tissues cell lines. CCK-8 assay, transwell invasion assay flow cytometry were conducted proliferation, apoptosis cells. Luciferase identify microRNA-target interaction. Results: Firstly, our...
Long non-coding RNA (lncRNA) SPRY4 intronic transcript 1 (SPRY4-IT1) is reported to play important roles in the occurrence and development of many tumors. However, possible role SPRY4-IT1 cisplatin (DDP) resistance non-small-cell lung cancer (NSCLC) remains unclear. The aim this study investigate functions molecular mechanisms underlying NSCLC.
In recent decades, antiangiogenic therapy, which blocks the supply of oxygen and nutrition to tumor cells, has become a promising clinical strategy for treatment patients with tumors. However, studies revealed that vasculogenic mimicry (VM), is process by vascular morphological structures are formed highly invasive been considered potential factor failure therapy in Thus, inhibition VM formation might be target improving outcome strategies. mechanism underlying still incompletely elucidated....
Objective: The objective of this study was to verify the clinical predictive performance methylated cysteine dioxygenase type 1 ( CDO1 m ) and CUGBP Elav-like family member 4 CELF4 in endometrial cancer (EC) women with postmenopausal bleeding (PMB). Material Methods: A single-center, prospective, case–control conducted Gansu Provincial Maternity Child-care Hospital 138 female patients enrolled 2022. All underwent body mass index (BMI) detection, transvaginal ultrasonography (TVUS)...
Abstract Multiple microRNAs (miRs) have also been implicated in ischemic brain injury. This research intended to probe the regulatory function and mechanism of miR‐15a on injury induced by oxygen‐glucose deprivation/reoxygenation (OGD/R) neurons rats. The OGD/R model was established with cortical separated from After transfection mimic negative control (NC), mimic, inhibitor NC inhibitor, OGD/R‐induced apoptosis were detected. Using bioinformatic softwares including TargetScan, miRanda,...
This prospective observational study with a control group aimed to compare the plasma levels of long non-coding RNA (lncRNA) LIPCAR between patients acute cerebral infarction (ACI) and healthy controls, assess prognostic abilities for adverse outcomes ACI at 1-year follow-up. Eighty ACI, whom 40 had large artery atherosclerosis (LAA) cardioembolism (CE) who were hospitalized Xi'an No. 1 Hospital from July 2019 June 2020, selected as case group. Age- sex-matched non-stroke same hospital...
Abstract As the key factor of polarity protein complex, Par6 not only regulates polarization processes, but also plays important roles in tumor metastasis and progression many epithelium malignancy tumors. Here, we showed that is an essential component glioma tumorigenesis. Our results indicated aberrant expression malignant tissues cell lines. We found regulation induces proliferation growth vivo vitro. Additionally, RNA‐seq revealed effects were associated with cyclin D1‐regulated cycle...
Abstract Objectives Alcohol consumption is one of the leading factors contributing to premature osteopenia. MicroRNA (miRNA) coordinates a cascade anabolic and catabolic processes in bone homeostasis dynamic vascularization. The aim was investigate protective role miR‐4286 alcohol‐induced loss its mechanism. Materials Methods effect alcohol on mesenchymal stem cells (BMSCs) human umbilical vein endothelial (HUVECs) explored via multiple vitro assays, including cell proliferation, QPCR,...
Abstract Vinculin is a highly conserved protein involved in cell proliferation, migration, and adhesion. However, the effects of vinculin on gastric cancer (GC) remain unclear. Therefore, we aimed to explore functional role GC, as well its underlying mechanism. Expression patients with GC was analyzed by real‐time polymerase chain reaction, Western blot analysis, immunohistochemistry. Overall survival evaluated Kaplan‐Meier method log‐rank test. The relationship between clinicopathological...
The aim of this research was to explore whether blood lipid parameters could predict tumor regression grading (TRG) and compare with the predictive value carcinoembryonic antigen (CEA) in patients locally advanced colorectal cancer (LARC) treated neoadjuvant chemoradiotherapy (nCRT). Between June 2011 January 2015, records 176 primary adenocarcinoma nCRT followed by radical surgery were reviewed retrospectively. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL),...
Formaldehyde (FA) is widely present in the environment, and also a mammalian metabolite. However, its biological role has not been well understood. Here, we show that FA plays an anti-apoptotic cultured hippocampal neurons: suppressed staurosporine-induced neuronal apoptosis inhibited activity of apoptosis-associated caspase-3/7 proteases concentration-dependent manner. Moreover, outward K(+) currents attenuated enhanced IK are associated with apoptosis. As increase critical for cell...