A5114859891- Video Coding and Compression Technologies
- Advanced Vision and Imaging
- Image and Video Quality Assessment
- Advanced Data Compression Techniques
- Cancer Mechanisms and Therapy
- Advanced Image Processing Techniques
- AI in cancer detection
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Digital Filter Design and Implementation
- Phytochemical compounds biological activities
- Lung Cancer Treatments and Mutations
- Smart Agriculture and AI
- Impact of Light on Environment and Health
- Neural Networks and Applications
- Genetic factors in colorectal cancer
- Connective tissue disorders research
- Cancer Genomics and Diagnostics
- Synthesis and biological activity
- Mechanisms of cancer metastasis
- Biological and pharmacological studies of plants
- Caveolin-1 and cellular processes
- Advanced Computing and Algorithms
- Remote Sensing in Agriculture
East China Normal University
2022-2025
Sun Yat-sen University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Central China Normal University
2024
Shanghai Jiao Tong University
2021-2024
Fujian University of Technology
2024
Hangzhou Women’s Hospital
2022
State Key Laboratory of ASIC and System
2021
China University of Geosciences
2021
Fudan University
2014-2021
Abstract Background Targeted therapy and immunotherapy put forward higher demands for accurate lung cancer classification, as well benign versus malignant disease discrimination. Digital whole slide images (WSIs) witnessed the transition from traditional histopathology to computational approaches, arousing a hype of deep learning methods histopathological analysis. We aimed at exploring potential models in identification subtypes mimics WSIs. Methods initially obtained 741 WSIs First...
The role of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) in osteosarcoma remains unknown. Then applying EFEMP1 siRNA, plasmids transfection and adding purified human cell lines, using immunohistochemistry on 113 tissues, demonstrated that was a poor prognostic indicator osteosarcoma; specifically upregulated associated with invasion metastasis vitro vivo. At the same time, we found direct regulatory effect MMP-2. Moreover, firstly marked induction...
Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in various cancers and implicated tumor progression metastasis. However, its functional significance underlying molecular mechanisms thyroid cancer remain to be elucidated. In the present study, we detected potential function of AEG-1 papillary (PTC). We also investigated relation between matrix metalloproteases (MMP)2 9 through immunohistochemistry, western blotting, real-time PCR, immunofluorescence staining,...
Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy Fen Wang,1,* Jia-Dong Pang,2,* Lei-lei Huang,1 Ran Wang,1 Dan Li,3 Kang Sun,4 Lian-tang Li-Ming Zhang2,* 1Department of Pathology, The First Affiliated Hospital Sun Yat-sen University, 2PCFM Lab and GDHPPC Lab, School Materials Science Engineering, Guangzhou, 3Guangdong Provincial Engineering Research Center Molecular Imaging, Fifth Zhuhai, 4School China *These authors contributed equally to this...
The latest video coding standard high-efficiency (HEVC) provides 50% improvement in efficiency compared to H.264/AVC meet the rising demands for streaming, better quality, and higher resolution. deblocking filter (DF) sample adaptive offset (SAO) play an important role HEVC encoder, SAO is newly adopted HEVC. Due high throughput requirement design challenges such as data dependence, external memory traffic, on-chip area become even more critical. To solve these problems, we first propose...
Affected by the global epidemic, non-contact unmanned control system provides people with safe human-computer interaction (HCI). This paper presents a radar hand gesture recognition based on real-time edge computing platform. The uses low-cost 24 GHz commercial low bandwidth frequency modulated continuous wave (FMCW) as detection source. For recognition, background echo of is fitted exponential weighted average method which can reduce hardware resource consumption when implementing field...
4165 Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis. While platinum-based therapies have demonstrated some therapeutic benefits, their associated toxicity underscores the need to identify patients who are most likely respond. Homologous recombination deficiency (HRD) has been linked improved sensitivity therapies, but its role in PDAC, particularly beyond BRCA1 and BRCA2 ( BRCA1/2 ) mutations, remains poorly understood. Methods: A...
High Efficiency Video Coding (HEVC), the latest video coding standard, aims to provide performance that is much superior of its predecessor, H.264, especially for high definition video. To fulfill this goal, inter-prediction unit (PU) partitions HEVC are more complex, and search range motion estimation (ME) larger. As a result, ME becomes bottleneck in design inter predictor. In response challenge, we developed hardware-oriented integer algorithm related hardware implementation. Our proposed...
Neural network has been one of the most useful techniques in area image analysis and speech recognition recent years. Long Short-Term Memory (LSTM), a popular type recurrent neural networks (RNNs), widely implemented on CPUs GPUs. However, software implementation cannot offer large parallelism for complicated computation LSTM, LSTM hardware implementations proposed yet are intensive non-configurable. In order to accelerate reduce resources consumption, this work, we present compact...
Abstract Tumor endothelial marker 8 (TEM8) was recently suggested as a putative anti-tumor target in several types of human cancer based on its selective overexpression tumor versus normal cells. The objective this study to detect the potential functions TEM8 osteosarcoma. Overall, mainly located cytoplasm and up-regulated osteosarcoma compared benign bone lesions adjacent non tissue (ANT). High expression group had significant lower overall survival rate than that low group. knock-down by...
Farnesoid X receptor (FXR) agonist obeticholic acid (OCA) has emerged as a potential therapy for nonalcoholic fatty liver disease (NAFLD). However, the side effects of OCA may limit its application in clinics. We identified previously that isotschimgine (ITG) is non‐steroidal FXR selective and potent therapeutic on NAFLD mice. Here, we aimed to evaluate ITG steatohepatitis (NASH) fibrosis used methionine choline deficient (MCD) diet‐induced NASH mice, bile duct ligation (BDL), carbon...
Erianin is a small chemical compound extracted from Dendrobium chrysotoxum and has excellent antineoplastic effects against variety of cancers. Combretastatin A-4 (CA4) the most effective member natural phenolic stilbene compounds isolated African willow tree Combretum caffrum. Ecust004 (Chemical Formula: C18H21NO7S) drug candidate optimized structure-activity relationship studies sulfamate derivatives CA4, which better bioavailability pharmacokinetic profiles than CA4.To investigate...
Abstract The performance of diagnostic tests in intervention trials Helicobacter pylori ( H.pylori ) eradication is crucial, since even minor inaccuracies can have major impact. To determine the cut-off point for 13 C-urea breath test C-UBT) and to assess if it be further optimized by serologic testing, mathematic modeling, histopathology validation were applied. A finite mixture model (FMM) was developed 21,857 subjects, an independent modified Giemsa staining conducted 300 selected...
Phenotypic characteristics of fruit particles, such as projection area, can reflect the growth status and physiological changes grapes. However, complex backgrounds overlaps always constrain accurate grape border recognition detection particles. Therefore, this paper proposes a two-step phenotypic parameter measurement to calculate areas overlapped These two steps contain particle edge contour fitting. For detection, an improved HED network is introduced. It makes full use outputs each...
The next generation standard of coding, High Efficiency Video Coding (HEVC) aims to provide significantly improved compression performance in comparison with all existing video coding standards, such as MPEG-4, H.263, and H.264/AVC. tool rate-distortion optimization (RDO) mode decision has proven be extremely important. Due the increase number intra prediction directions large size unit (CU), (PU) transform (TU), involved RDO process rises dramatically, which is an...
The latest High Efficiency Video Coding standard achieves twice the coding efficiency of H264 through a complex rate-distortion optimization (RDO). coded bit-streams are produced with context adaptive binary arithmetic (CABAC). CABAC itself is very time-consuming process that includes binarization, modeling, interval subdivision, renormalization, outstanding bit handling, and updating. aim this research to speed up several simplifications. First, we approximate three parts CABAC, i.e.,...