A5061994232- Gastrointestinal motility and disorders
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Plant and Fungal Species Descriptions
- Transplantation: Methods and Outcomes
- Genomics and Phylogenetic Studies
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Glioma Diagnosis and Treatment
- Genetic diversity and population structure
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Infant Health and Development
- Estrogen and related hormone effects
- Esophageal and GI Pathology
- Genital Health and Disease
- Metastasis and carcinoma case studies
- Polysaccharides and Plant Cell Walls
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Spinal Cord Injury Research
- Gallbladder and Bile Duct Disorders
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
Shanxi Agricultural University
2006-2025
Sun Yat-sen University
2015-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2017-2024
Jinan University
2024
Wuzhou Red Cross Hospital
2024
Beijing Tsinghua Chang Gung Hospital
2024
Southern University of Science and Technology
2024
Capital Medical University
2016-2023
Central South University
2019-2023
Beijing Hospital of Traditional Chinese Medicine
2016-2023
// Lingli Long 1, * , Han Qiu 2, Bing Cai 6 Ningning Chen 3 Xiaofang Lu 4 Shuhui Zheng 1 Xiaoxin Ye 5 and Yubin Li Translation Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China 2 Department of Medicine, Ka Shing Faculty University Hong Kong, Orthopedics, Seventh Yat-sen Shenzhen, Pathology, New South Wales, Sydney, Australia Reproductive Center the These authors have contributed equally to this work Correspondence to: Li, email: liyubin97200@163.com...
// Fang Liu 1, 2, 3, * , Qing-Hua Cao 4, De-Jian Lu Bin Luo 2 Xiao-Fang 4 Rong-Cheng 3 Xiao-Guang Wang 1 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Faculty Forensic Medicine, ZhongShan School Sun Yat-sen 510080, Cancer Center and Traditional Chinese Medicine-Integrated 510315, Pathology, The First Affiliated Hospital These authors have contributed equally to this work Correspondence to: Wang, e-mail: wxguang@mail.sysu.edu.cn Luo,...
BackgroundLimited data exist on VTE risk and prophylaxis in Chinese inpatients. The Identification of Hospitalized Patients' Risk Profile for Venous Thromboembolism-2 (DissolVE-2), a nationwide, multicenter, cross-sectional study, was therefore designed to investigate prevalence risks evaluate implementation compliant with the latest guidelines (American College Chest Physicians [CHEST], 9th edition).MethodsAdults admitted (≥ 72 h) 60 urban, tertiary hospitals due acute medical conditions or...
The goal of our study is to evaluate the effect Scutellarin on type II diabetes-induced testicular disorder and show mechanism Scutellarin’s action. We used streptozotocin high-fat diet establish diabetic rat model. TUNEL haematoxylin eosin staining were apoptotic cells morphologic changes. Immunohistochemical was measure expression level vascular endothelial growth factor blood vessel density in testes. Oxidative stress testes epididymis tested by fluorescence spectrophotometer ELISA....
Ovarian cancer (OvCa)-tumor-associated macrophages (TAMs) spheroids are abundantly present within ascites of high malignant patients. This study investigated the mutual interaction OvCa cells and TAMs in spheroids.
Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in various cancers and implicated tumor progression metastasis. However, its functional significance underlying molecular mechanisms thyroid cancer remain to be elucidated. In the present study, we detected potential function of AEG-1 papillary (PTC). We also investigated relation between matrix metalloproteases (MMP)2 9 through immunohistochemistry, western blotting, real-time PCR, immunofluorescence staining,...
Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into biodegradable micelles in aqueous solutions. Owing to low pH values inside tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high loading ability release behavior within cells or tissues upon changes physical...
As an RNA-binding protein, insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) is involved in enhancing the progression of a few malignant tumors by recognizing N6-methyladenosine on targeted RNA. However, specific effects IGF2BP2 gastric cancer (GC) and underlying mechanisms remain unclear. In this study, expression level was evaluated analyzing data from public database performing immunohistochemical staining with GC specimens. The effect cell metastasis investigated Transwell...
Excessive neutrophil extracellular traps (NETs) is involved in the progression of acute pancreatitis (AP) but mechanisms controlling NETs formation AP are not fully understood. Therefore, our study sought to investigate mechanism highly expressed P-selectin stimulating AP.NETs was detected by flow cytometry, immunofluorescence staining, and cf-DNA MPO-DNA complexes were measured as biomarkers formation. Neutrophils treated with pharmacological inhibitors examined western blot, staining...
Abstract Stress‐induced hair loss is a prevalent health concern, with mechanisms that remain unclear, and effective treatment options are not yet available. In this study, we investigated whether stress‐induced was related to an imbalanced immune microenvironment. Screening the skin‐infiltrated cells in stressed mouse model, discovered significant increase macrophages upon stress induction. Clearance of rescues mice from shedding depletion follicle stem (HFSCs) skin, demonstrating role...
BackgroundAccumulating evidence indicates that tumour-infiltrating lymphocytes (TILs) are the primary determinant of survival outcomes in various tumours. Thus, we sought to investigate TIL distribution and density gastrointestinal stromal tumours (GISTs) develop an immune infiltration (II)-based signature predict prognosis.MethodsThe expression 8 features tumour centre (TC) margin (TM) PD-L1 435 GIST patients was investigated by immunohistochemistry. Then, a 4-feature-based II-GIST...
Traditional therapeutic strategies for spinal cord injury (SCI) are insufficient to repair locomotor function because of the failure axonal reconnection and neuronal regeneration in injured central nervous system (CNS). Neural stem cell (NSC) transplantation has been considered a potential strategy is generally feasible repairing neural circuit after SCI; however, most formidable problem that differentiation rate NSCs quite limited. Therefore, it essential induce improve repair. Our results...
As a CRISPR-Cas9-based tool to help scientists investigate gene functions, Cancer Dependency Map genes (CDMs) include an enormous series of loss-of-function screens based on genome-scale RNAi. These participate in regulating survival and growth tumor cells, which suggests their potential as novel therapeutic targets for malignant tumors. By far, studies the roles CDMs gastric adenocarcinoma (GA) are scarce only small fraction have been investigated. In present study, datasets differentially...
The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or apoptosis of some cancers, indicating the TRPM7 as an anti-anaplastic target. Here, we identified characteristic channel currents human malignant glioma MGR2 cells, which could be blocked by a pharmacologic inhibitor Gd3+. We mined clinical sample data from Oncomine Database and found that tissues expressed higher mRNA than normal brain ones. Importantly, widely used anesthetic midazolam...
Recent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to pathogeneses of functional dyspepsia (FD). Thus, restoring normal integrity becomes a potential therapeutic strategy treatment FD. Sini-San (SNS) is traditional Chinese prescription exhibits effects FD, but underlying mechanisms remain not well understood. FD rats were established by tail clamping method effect SNS was evaluated measuring visceral sensitivity...
Constipation is a common functional gastrointestinal disorder, which needs more effective treatment approaches. Houpo Paiqi Mixture (HPPQM) type of Chinese patent medicine developed from classical formula that has been widely applied to the intestinal motility disorder. Here we aim assess effectiveness HPPQM in constipation rat models and its potential mechanism.UPLC-MS/MS was performed investigate chemical component HPPQM. Rats were randomly divided into normal control, model (CM), (low,...
This study was designed to investigate the effect of Aurantii fructus immaturus flavonoid (AFIF) on contraction isolated gastric smooth muscle in rats and explore its underlying mechanisms. Isolated antral longitudinal strip (ALSMS) pyloric circular (PCSMS) were suspended tissue chambers. The responses ALSMS PCSMS administration AFIF observed. Cyclic guanosine monophosphate (cGMP) protein kinase G (PKG) levels measured by ELISA kits. In this study, showed no significant contraction, but it...
In this study, we investigated the relationship between tryptophan-5-hydroxytryptamine metabolism, depressive disorder, and gastrointestinal dysfunction in rats after myocardial infarction. Our goal was to elucidate physiopathologic bases of somatic/psychiatric depression symptoms A infarction model established by permanent occlusion left anterior descending coronary artery. Depression-like behavior evaluated using sucrose preference test, open field forced swim test. Gastric retention...
This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms.IBS-D model were induced by neonatal maternal separation (NMS) combined with restraint stress (RS). In vivo experiments, randomly divided into 5 groups: NMS + RS, FLCWK (low dose, middle high dose), pinaverium bromide. The normal control (no handling) classified as NH group. therapeutic evaluated fecal...