A5015668217- Asthma and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- IL-33, ST2, and ILC Pathways
- Thermal Regulation in Medicine
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Food Allergy and Anaphylaxis Research
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Chemokine receptors and signaling
- High Altitude and Hypoxia
- Organ Transplantation Techniques and Outcomes
- Neonatal Health and Biochemistry
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Inflammasome and immune disorders
- Cannabis and Cannabinoid Research
Hohai University
2025
Shanghai Jiao Tong University
2009-2024
XinHua Hospital
2011-2024
Ganzhou People's Hospital
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shanghai Children's Medical Center
2015-2021
BGI Group (China)
2018
Ruijin Hospital
2006-2015
Sichuan University
2013
Heme oxygenase-1 (HO-1) has anti-inflammatory effects in asthma. CD4+CD25(high) regulatory T cells (Treg) are a potent immunoregulator that suppresses the immune response. We studied of HO-1-mediated Treg on suppression allergic airway inflammation by comparing mice treated with hemin, OVA, Sn-protoporphyrin (SnPP), and hemin plus SnPP. Airway responsiveness, eosinophil infiltration, level OVA-specific IgE, numbers general eosinophils particular bronchial alveolar lavage fluid were lower...
Abstract Background Airway inflammation is mainly mediated by T helper 2 cells (Th2) that characteristically produce interleukin (IL)-4, IL-5, and IL-13. Epidemiological studies have revealed an inverse association between the dietary intake of vitamin A occurrence asthma. Serum concentrations are significantly lower in asthmatic subjects than healthy control subjects. It has been reported all-trans retinoic acid (ATRA), a potent derivative A, regulates immune responses. However, its role...
Expanded carrier screening (ECS) has been demonstrated to increase the detection rate of carriers compared with traditional tests. The aim this study was assess potential value ECS for clinical application in Southern China, a region high prevalence thalassemia and diverse ethnic groups, provide reference future implementations areas similar population characteristics. A total 10,476 prenatal/preconception couples from 34 self-reported groups were simultaneously tested analyzed anonymously...
Abstract Stress‐induced hair loss is a prevalent health concern, with mechanisms that remain unclear, and effective treatment options are not yet available. In this study, we investigated whether stress‐induced was related to an imbalanced immune microenvironment. Screening the skin‐infiltrated cells in stressed mouse model, discovered significant increase macrophages upon stress induction. Clearance of rescues mice from shedding depletion follicle stem (HFSCs) skin, demonstrating role...
ABSTRACT Objective: Inflammatory bowel disease (IBD) is characterized by recurrent and severe gastrointestinal inflammation. Activation of inflammatory cells, such as T H 17 lymphocytes, and/or deficiency regulatory cells (T reg ) are responsible for the pathogenesis IBD. As an acute phase reactant, heme oxygenase‐1 (HO‐1) has been shown to play anti‐inflammatory immunomodulatory role in many processes. In this study, we used a dextran sulfate sodium (DSS)–induced murine colitis model...
Abstract Background Primary immunodeficiency disease (PID) is a disorder caused by an inherited flaw in the immune system that increases susceptibility to infections. Methods In this study, 112 children with PID were diagnosed and classified based on 2017 criteria presented International Union of Immunological Societies (IUIC) single tertiary care center from January 2013 November 2018. We retrospectively studied clinical features those followed-up them as well. Results It was revealed...
The COVID-19 pandemic have impacts on the prevalence of other pathogens and people's social lifestyle. This study aimed to compare pathogen, allergen micronutrient characteristics pediatric inpatients with pneumonia prior during in a large tertiary hospital Shanghai, China. Patients admitted Department Pediatric Pulmonology Xinhua Hospital between March-August 2019 2020 were recruited. And clinical patients compared those 2020. Hospitalizations for decreased by 74% after pandemic. For...
Ship–bridge collisions in inland waterways pose a serious threat to bridge infrastructure, often resulting structural damage and jeopardizing safety. Despite the widespread deployment of collision warning systems, these systems fail function effectively due factors such as weather conditions, equipment malfunctions, human error. Current alarming technologies, wavelet-based methods, are limited by poor real-time performance, high sensitivity noise, low localization accuracy, which hinder...
Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates Th2 immunity not fully understood. Recent studies show basophils play important roles in initiating some inflammatory models. Here we explored role of ovalbumin (OVA) -induced BALB/c mice. We found OVA sensitization challenge resulted a significant increase amount blood lung, along with up-regulation activation marker CD200R. However, depletion MAR-1...
Abstract: HO‐1 is a rate‐limiting enzyme in hemoglobin metabolism, and exerts anti‐inflammatory as well anti‐apoptotic effects. Previous studies have shown that expression of can prolong the survival concordant transplanted organs. However, little known about precise effect mechanism discordant xenotransplantation. In this study, we investigated role cardiac First, HUVECs were used to assess on TNF‐α‐induced apoptosis. Results showed TNF‐α induced apoptosis dose‐dependent manner. Moreover,...
This study compared the therapeutic effects of two techniques for surgical decompression treatment ulnar nerve entrapment at elbow: subcutaneous transposition and modified submuscular with Z-lengthening pronator teres origin. A total 278 patients (McGowan grades I-III) were randomly assigned to undergo one these techniques. All followed-up 2 years. The assessed by preoperative postoperative cross-sectional area, motor conduction velocity, sensory velocity action potential. parameters...
The anti-inflammatory role of heme oxygenase-1 (HO-1) has been studied extensively in many disease models including asthma. Many cell types are targets HO-1, such as dendritic cells and regulatory T cells. In contrast to previous reports that HO-1 had limited effects on basophils, which participate helper type 2 immune responses antigen-induced allergic airway inflammation, we demonstrated this study, for the first time, up-regulation significantly suppressed maturation mouse decreased...