A5008202239- Immunotherapy and Immune Responses
- Helicobacter pylori-related gastroenterology studies
- Asthma and respiratory diseases
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Mast cells and histamine
- Renal Diseases and Glomerulopathies
- Immune cells in cancer
- Ocular Surface and Contact Lens
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- S100 Proteins and Annexins
- Corneal Surgery and Treatments
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Psychosocial Factors Impacting Youth
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Lipids, and Metabolism
Peking University Cancer Hospital
2010-2025
Peking University
2010-2025
Hunan Normal University
2025
University of Girona
2024
Traditional Chinese Medicine Hospital of Kunshan
2024
Shanghai University of Traditional Chinese Medicine
2024
Korea University
2024
University of Nevada, Reno
2024
Sichuan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as potential microbial dysbiosis. In our study, we investigated association between gut microbiota and H. pylori-related lesions in 47 subjects by deep sequencing 16S ribosomal RNA (rRNA) gene fecal samples. The dominant phyla samples were Bacteroidetes, Firmicutes Proteobacteria with average relative abundances 54.77%, 31.37%...
To develop a mouse model of limbal stem cell deficiency (LSCD) by topical administration benzalkonium chloride (BAC).BAC solutions (0%-0.5%) were applied to the ocular surface for 4 weeks. Corneal neovascularization, inflammation, and epithelial status observed under slit-lamp microscope. The eyeball tissues collected at 12 weeks labeled with series antibodies. Limbal structure was evaluated light transmission electron microscopy (TEM). impression cytology performed weeks, specimens periodic...
Abstract POLRMT (RNA polymerase mitochondrial) is responsible for the transcription of mitochondrial genome encoding key components oxidative phosphorylation. This process important cancer cell growth. The current study tested expression and potential functions in non-small lung (NSCLC). TCGA cohorts results from local tissues showed that overexpressed human tissues. In both primary NSCLC cells A549 cells, silencing (by targeted lentiviral shRNAs) or knockout (through CRSIPR/Cas9 gene...
Abstract Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during development malignancy. However, it is yet to be determined if targeting oncometabolite-associated nociception processes can hinder OSCC progression. In this study, we reported that nociceptive endings infiltrating both samples and mouse tumor xenografts were with poorer outcomes drove progression...
To investigate the therapeutic effects and possible mechanisms of epidermal growth factor (EGF) on mouse dry eye model induced by benzalkonium chloride (BAC).The drop containing EGF was topically administered (3 ng per day) a BAC-induced model. The following clinical indications were evaluated Days 2, 4, 6: tear break-up time (BUT), corneal fluorescein staining, inflammatory index, volume. Global specimens collected Day 6 then examinations performed: histologic investigation, TUNEL assay to...
AIM:To perform sequencing analysis in patients with very early-onset inflammatory bowel disease (VEO-IBD) to determine the genetic basis for VEO-IBD Chinese pediatric patients. METHODS:A total of 13 were diagnosed from May 2012 and August 2014.The relevant clinical characteristics these analyzed.Then DNA peripheral blood was extracted.Next generation (NGS) based on an Illumina-Miseq platform used analyze exons coding regions 10 candidate genes: IL-10 , IL-10RA IL-10RB NOD2 FUT2 IL23R GPR35...
Abstract The inflammatory response in acute pancreatitis (AP) is associated with acinar-to-dendritic cell transition. CD4 + T-cell-mediated adaptive immune necessary for pancreatic damage. However, the effect of transition on T-cell and regulatory mechanism remain undefined. A mouse animal model AP was established by repeated intraperitoneal injection CAE. mTOR inhibitor rapamycin administered before induction. Primary acinar cells were isolated co-incubated subsets differentiated T cells....
Objective: To identify proteins associated with the risk of gastric cancer (GC) and build a protein score for prediction GC based on proteomic analysis. Methods: Gastric mucosal proteomics data were used to construct Dataset One, comprising 94 cases 230 individuals different stages lesions. The recruited from National Upper Gastrointestinal Cancer Early Detection (UGCED) Program in Linqu, Shandong Province, as well clinical patients Fifth Medical Center, General Hospital PLA, Peking...
Prey capture was evaluated as a behavioral biomarker of contamination by examining feeding behavior adult mummichogs (Fundulus heteroclitus) from 13 sites. ability related to sediment and tissue contaminant levels with previous genetic analyses. The contaminants at site were highly correlated each other, confounding the impacts individual contaminants. number prey (grass shrimp) captured highest in three cleanest Sites lowest rates generally more contaminated. captures all sites variable,...
Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase which metabolizes angiotensin II (Ang II) to generate Ang-(1-7), has been shown prevent cardiac hypertrophy and injury but the mechanism remains elusive. Irbesartan dual actions of receptor blockade peroxisome proliferator-activated receptor-γ (PPARγ) activation. We hypothesized that irbesartan would exert its protective effects on ACE2 deficiency-mediated myocardial fibrosis via PPARγ signaling.10-week-old knockout (ACE2KO;...
Abstract Background Specific JAK / STAT pathways play a critical role in the functional differentiation of distinct Th subsets. Previously, we showed that HO ‐1, stress‐inducible protein, inhibits Th17 cell and alleviates neutrophilic airway inflammation, but responsible molecular basis remains unclear. Methods We employed Th17‐skewing NEA mouse models to study ‐1 regulating IL ‐6‐ 3‐ ROR γt/ SOCS 3 signaling pathway control cell‐mediated inflammation. The levels cytokines expressions...
The transcription factor, interferon regulatory factor 4 (IRF4), serves an essential role in the regulation of immune responses, and has been reported to act as a diagnostic prognostic marker for various hematological malignancies. present study aimed investigate whether IRF4 could exert effects on human non‑small cell lung cancer (NSCLC) explore underlying mechanism. mRNA protein expression was detected NSCLC tissues using reverse‑transcription quantitative polymerase chain reaction western...
Preeclampsia (PE) is a multisystemic maternal syndrome with substantial and fetal morbidity mortality. Currently, there no clinically viable non-invasive biomarker assay for early detection, thus limiting the effective prevention therapeutic strategies PE. We conducted discovery-training-validation three-phase retrospective prospective study cross-platform multicenter cohorts. The initial biomarkers were discovered verified in tissue specimens by small RNA sequencing qRT-PCR. A miRNA...
Metabolites and their interactions with microbiota may be involved in Helicobacter pylori-associated gastric lesion development. This study aimed to explore metabolite alterations upon H. pylori eradication possible roles of microbiota-metabolite progression precancerous lesions. Targeted metabolomics assays 16S rRNA gene sequencing were conducted investigate metabolic microbial paired biopsy specimens 58 subjects successful 57 failed anti-H. treatment. Integrative analyses performed by...
Abstract: The stomach is a crucial digestive organ in the human body, highly susceptible to inflammation or pathogen invasion, which can lead various gastric diseases, including cancer. Toll-like receptors (TLRs) are first line of defense against invasion. TLR4, member TLRs family, recognizes and danger-related molecular patterns induce inflammatory responses. Helicobacter pylori (H. pylori) significant factor health, TLR4 H. -LPS trigger an response. Downstream signaling generates...
The Mongolian sheep, emblematic of the Inner grasslands, is renowned for its exceptional stress resistance and adaptability to harsh environments, drawing considerable attention. Recent research has unveiled novel role γ-aminobutyric acid (GABA) in combating oxidative stress. This investigation examined how GABA impacts renal-cortex medulla cells from sheep exposed high-glucose conditions, utilizing gene expression analysis non-targeted metabolomics. Elevated glucose levels significantly...
Survivin and livin are novel members of the inhibitor apoptosis gene family (IAP) that controls mitotic progression induces tumor cell invasion. This study aims to evaluate association both expression with clinical outcomes risk recurrence in patients non-muscle invasive bladder cancer (NIMBC).We investigated survivin 72 NMIBC samples using immunohistochemical staining (Envision Method). were considered high-expressed when more than 10% cells expressed. The archival tissue specimens from 11...