A5084275151- Comics and Graphic Narratives
- Mitochondrial Function and Pathology
- Sexuality, Behavior, and Technology
- Metabolism and Genetic Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Historical and Literary Studies
- Digital Games and Media
- Retinal Development and Disorders
- MRI in cancer diagnosis
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Lipid metabolism and biosynthesis
- Advanced Neuroimaging Techniques and Applications
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Diverse multidisciplinary academic research
- Endoplasmic Reticulum Stress and Disease
- Shakespeare, Adaptation, and Literary Criticism
- ATP Synthase and ATPases Research
- Psychoanalysis and Psychopathology Research
- MicroRNA in disease regulation
- Academic and Historical Perspectives in Psychology
Université du Québec à Montréal
2021
Institut Universitaire en Santé Mentale de Québec
2014
Université Laval
2010-2012
Contacts between organelles create microdomains that play major roles in regulating key intracellular activities and signaling pathways, but whether they also regulate systemic functions remains unknown. Here, we report the ultrastructural organization dynamics of inter-organellar contact established by sheets curved rough endoplasmic reticulum closely wrapped around mitochondria (wrappER). To elucidate vivo function this contact, mouse liver fractions enriched wrappER-associated are...
Significance We provide, to our knowledge, the first in vivo quantitative description of adaptive response mitochondrial reticulum metabolic transition occurring liver hours after feeding. When nutrients become limiting, mitochondria size, cristae density, and respiratory capacity drop, but mitochondria–ER contacts, which control calcium lipids fluxes between these organelles, double. A proteolytic inactivation Optic atrophy 1 (Opa1), a major regulator fusion architecture, accompanies...
Hepatic lipid homeostasis depends on intracellular pathways that respire fatty acid in peroxisomes and mitochondria, systemic secrete into the bloodstream, either free or condensed very-low-density lipoprotein (VLDL) triglycerides. These are interdependent, but it is unclear whether how they integrate a single cellular circuit. Here, we report mouse liver wrappER, distinct endoplasmic reticulum (ER) compartment with apparent acid- VLDL-secretion functions, connects mitochondria. Correlative...
Oligodendrocytes are the myelin-forming cells of central nervous system that facilitate transmission axonal electrical impulses. Using transgenic mice expressing 2',3' cyclic nucleotide 3' phosphodiesterase (CNPase)-enhanced green fluorescent protein, a three-dimensional reconstruction tool and analysis, we illustrate three morphologically different oligodendrocyte types exist in hippocampus. Those ramified type have most numerous processes, largest cell body, occupy area form beaded-like...
To obtain an accurate representation of a brain structural connectivity, diffusion MRI and fiber tracking depend on good understanding white matter structures. Although the methods work well when performed in single orientation bundles, most are limited more complex cases, especially to take into account crossing, fanning, kissing fibers. A recent international challenge concluded that algorithms generated 4–5 times false positive tracks than true average. This was attributed large part lack...