A5035204081- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Cardiac Arrhythmias and Treatments
- Advanced X-ray and CT Imaging
- Radiation Effects and Dosimetry
- Meningioma and schwannoma management
- Cardiac electrophysiology and arrhythmias
- Radiation Effects in Electronics
- Osteomyelitis and Bone Disorders Research
- Radiopharmaceutical Chemistry and Applications
- Orthopedic Infections and Treatments
- Management of metastatic bone disease
- Atrial Fibrillation Management and Outcomes
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Boron Compounds in Chemistry
- Physics of Superconductivity and Magnetism
- Radiation Detection and Scintillator Technologies
- Cell Image Analysis Techniques
- Machine Learning in Materials Science
- Superconductivity in MgB2 and Alloys
Stanford Medicine
2017-2025
Stanford University
2017-2025
Neurological Surgery
2024
Vanderbilt University
2024
Queen Square Radiosurgery Centre
2024
Kingston University
2018-2019
University of Wisconsin–Madison
2019
Community Regional Medical Center
2010-2016
California State University, Fresno
2016
Southwest General Health Center
2010
Abstract Purpose The self‐shielding radiosurgery system ZAP‐X consists of a 3 MV linear accelerator and eight round collimators. For this system, it is common practice to perform the reference dosimetry using largest 25 mm diameter collimator at source‐to‐axis distance (SAD) 45 cm with PTW Semiflex3D chamber placed measurement depth 7 in water. Existing protocols do not provide correction for these conditions. Therefore, Monte Carlo simulations were performed quantify associated beam quality...
The purpose of this article is to investigate and characterize from a physics perspective the Zap-X (ZAP Surgical Systems, Inc., San Carlos, CA), new, dedicated self-contained self-shielded radiosurgery system, focusing on beam energy performance, leakage, radiation safety, dose delivery accuracy, regulations, quality assurance, treatment planning. This investigation required establish mechanical overall performance specifications system baseline parameters for future clinical usage. applied...
The precision and quality of a radiosurgical procedure depend on the ability to immobilize position patient's head. Often, this is accomplished by means mechanical headframe. accurately head keep it in place during depends directly rigidity This characteristic Leksell headframe (Elekta, Atlanta, GA, US) was evaluated determining impact typical forces encountered clinical practice its rigidity. A quantitative analysis individual then used draw conclusions headframe's target at desired...
The Zap-X is a self-contained and first-of-its-kind self-shielded therapeutic radiation device dedicated to brain as well head neck stereotactic radiosurgery (SRS). By utilizing an S-band linear accelerator (linac) with 2.7 megavolt (MV) accelerating potential incorporating radiation-shielded mechanical structures, the does not typically require bunker, thereby saving SRS facilities considerable cost. At same time, features of are designed for more consistency protection, reducing risk...
The work described here compared the available technical solutions for treatment of ventricular tachycardia with stereotactic body radiation therapy. Due to complexity target motion during cardiac and pulmonary as well several proximate radio-sensitive structures tracheobronchial tree esophagogastrointestinal tract, four potential candidates this were identified: Accuray CyberKnife (Accuray Incorporated, Sunnyvale, California, United States), Varian TrueBeam (Varian Medical Systems, Palo...
Essential tremor (ET) is one of the most common adult movement disorders. As worldwide population ages, incidence and prevalence ET increasing. Although cases can be managed conservatively, there a subset that refractory to medical management. By virtue being "reversible", deep brain stimulation (DBS) ventral intermediate nucleus (VIM) thalamus commonly accepted intervention. an alternative invasive expensive DBS, has been renaissance in treating with lesion-based approaches, spearheaded...
Introduction The ZAP-X is a novel self-contained and first-of-its-kind self-shielded therapeutic radiation device dedicated to brain head neck radiosurgery. By utilizing 2.7-MV linear accelerator incorporating design in which beam stop major mechanical elements serve shielding function, the Zap-X does not typically require bunker. unique collimator of especially critical performance overall system. consists shielded tungsten wheel oriented with its rotational axis perpendicular beam's...
Cardiac arrhythmias, such as ventricular tachycardia, are disruptions in the normal cardiac function that originate from problems electrical conduction of signals inside heart. Recently, a non-invasive treatment option based on external photon or proton beam irradiation has been used to ablate arrhythmogenic structures. Especially therapy, its steep dose gradient, it is crucial monitor motion heart order ensure radiation delivered correct location. Transthoracic ultrasound imaging potential...
Modulation of pathological neural circuit activity in the brain with a minimum complications is an area intense interest.The goal study was to alter neurons' physiological states without apparent damage cellular integrity using stereotactic radiosurgery (SRS).We treated 7.5 mm-diameter target on visual cortex Göttingen minipigs doses 40, 60, 80, and 100 Gy. Six months post-irradiation, pigs were implanted 9 mm-wide, eight-shank multi-electrode probe, which spanned radiation focus as well...
Abstract BACKGROUND AND IMPORTANCE The Zap-X system (Zap Surgical Systems Inc, San Carlos, California) is a radically new surgical robot designed for brain and head neck radiosurgery. It represents the first dedicated stereotactic radiosurgery platform in almost half century optimizing goals of safety, speed, accuracy. was used required Chinese National Medical Products Administration clinical study. In early January 2020, 2 patients were treated with prior to national COVID-19 lockdown....
The ZAP-X® is a newly designed, self-contained, and first-of-its-kind self-shielded therapeutic radiation therapy device dedicated to brain head neck stereotactic radiosurgery (SRS). By using an S-band linear accelerator (linac) employing integrated minimal but sufficient shielding, the ZAP-X does not typically require bunker. At same time, features of are designed for more consistency protection, reducing risk workers others potentially exposed from poorly or constructed radiotherapy vault....
Various small-field radiation dose detectors were systematically compared and their impact on measured beam performance of the ZAP-X® dedicated stereotactic radiosurgery system (ZAP Surgical Systems, Inc., San Carlos, CA, USA) was determined. Three Physikalische Technische Werkstaetten (PTW) diodes, i.e., microSilicon, microDiamond, Stereotactic Radiosurgery (SRS) diode (PTW-Freiburg, Freiburg, Germany), as well Gafchromic™ External Beam Therapy 3 (EBT) film (Ashland, Wilmington, DE, USA),...
Abstract Background The ZAP‐X system is a novel gyroscopic radiosurgical based on 3 MV linear accelerator and collimator cones with diameter between 4 25 mm. Advances in imaging modalities to detect small early‐stage pathologies allow for an early less invasive treatment, where smaller matching the anatomical target could provide better sparing of surrounding healthy tissue. Purpose A mm cone was developed. This study aims investigate usability commercial diode detector (microSilicon)...
In a treatment planning study, radiosurgical plans designed to produce lesions on the left atrium were created using two different methodologies. one, structures in heart (mitral valve and coronary arteries) designated as critical while this was not done second plan. The that compared with standards for dose used when treating spine tumors. Although dosage whole greatly exceeded standards, only ventricles considered, plan where mitral spared very close standards. received substantially...
Introduction Accurate dose delivery is critical to the success of stereotactic radiosurgery. Unfortunately, verification accuracy treatment remains a challenging problem. Existing radiosurgery paradigms are limited in their ability verify accurate radiation beams using data sampled from beam after it has traversed patient. The Zap-X Radiosurgery System (Zap Surgical Systems, San Carlos, CA) addresses this issue by implementing fully integrated system that utilizes factory commissioned...
We present the Bio-Silicon Intelligence System (BSIS), an innovative hybrid platform that integrates biological neural networks with silicon-based computing. The BSIS, a Physics-Informed Hybrid Hierarchical Reinforcement Learning State Machine, employs carbon nanotube-coated electrodes to interface rat brains computational systems, enabling high-fidelity interfacing and bidirectional communication through self-organizing systems in both silicon forms. Our system leverages analogue digital AI...