A5038898633- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Brain Tumor Detection and Classification
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Optical Imaging and Spectroscopy Techniques
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- MRI in cancer diagnosis
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Neuroscience and Neural Engineering
Aarhus University Hospital
2015-2024
Aarhus University
2019-2024
Amsterdam UMC Location University of Amsterdam
2019
University of Lisbon
2016
A better understanding of transcriptional evolution IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n 245 validation) on paired primary-recurrent resections patients treated with the current standard care. Transcriptional subtypes form an interconnected continuum in a two-dimensional space. Recurrent tumors show preferential mesenchymal progression. Over time, hallmark genes are not significantly altered. Instead,...
Precision medicine trials in glioblastoma (GBM) are often conducted at tumor recurrence. However, second surgeries for recurrent GBM not routinely performed, and therefore, molecular data trial inclusion predominantly derived from the primary sample. This study aims to establish whether targets change during progression and, if so, this affects precision design.We collected 186 pairs of primary-recurrent samples patients receiving chemoradiotherapy with temozolomide sequenced approximately...
Abstract Background Standard treatment for patients with newly diagnosed glioblastoma includes surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy (TMZ/RT→TMZ). The proteasome has long been considered a promising therapeutic target because of its role as central biological hub in tumor cells. Marizomib is novel pan-proteasome inhibitor that crosses the blood–brain barrier. Methods European Organisation Research Treatment Cancer 1709/Canadian Trials Group CE.8 was multicenter,...
OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective this study was to evaluate clinical feasibility using a recently described method determining IDH mutation status by magnetic resonance spectroscopy (MRS) detect presence 2-hydroxyglutarate (2HG), metabolic product mutant enzyme. METHODS By extending imaging time 6 minutes, authors were able include point-resolved (PRESS) MRS sequence their...
Glioblastoma ranks among the most lethal cancers, with current therapies offering only palliation. Paracrine vascular endothelial growth factor (VEGF) signaling has been targeted using anti-angiogenic agents, whereas autocrine VEGF/VEGF receptor 2 (VEGFR2) is poorly understood. Bevacizumab resistance of VEGFR2-expressing glioblastoma cells prompted interrogation VEGF-C/VEGFR2 in glioblastoma.Autocrine was functionally investigated RNA interference and exogenous ligands patient-derived...
Abstract Background Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and effort sought to prospectively validate a revised response assessment in metastasis. Methods Coded paired cerebrospinal 20 patients with metastases from solid cancers at baseline follow-up after treatment instructions were provided via imaging platform. The Kappa coefficient was used evaluate interobserver pairwise agreement....
Background: The extent of radiation therapy (RT)-induced changes in cognitive function is unknown. RT with protons instead photons spares the healthy brain tissue more and believed to reduce risk dysfunction. There modest knowledge on which parts we need spare, prevent To uncover domains most affected, compared functioning tumor patients treated neurosurgery alone.Methods: A cross-sectional study assessing 110 a primary grades I–III or medulloblastoma (grade IV) at Aarhus University Hospital...
Abstract Background Preclinical studies suggest that skull remodeling surgery (SR-surgery) increases the dose of tumor treating fields (TTFields) in glioblastoma (GBM) and prevents wasteful current shunting through skin. SR-surgery introduces minor defects to focus cancer-inhibiting currents toward increase treatment dose. This study aimed test safety feasibility this concept a phase I setting. Methods Fifteen adult patients with first recurrence GBM were treated personalized SR-surgery,...
Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory behavior studies. Devices capable of both recording brain-computer interfaces (BCIs) should ideally operate un-tethered allow chronic longitudinal manipulations the freely moving animal. In this study, we designed new intracortical BCI feasible telemetric stimulating local gray white matter visual neural circuit after irradiation exposure. To increase translational reliance, put forward...
EGFR is among the genes most frequently altered in glioblastoma, with exons 2-7 deletions (EGFRvIII) being its common genomic mutations. There are conflicting reports about prognostic role and it remains unclear whether how differs signaling compared wildtype EGFR.To better understand oncogenic of EGFRvIII, we leveraged 4 large datasets into 1 glioblastoma transcriptome dataset (n = 741) alongside 81 whole-genome samples from 2 datasets.The EGFRvIII/EGFR expression ratios differ strongly...
The Danish Neuro Oncology Group (DNOG) has established national consensus guidelines for the delineation of organs at risk (OAR) structures based on published literature. This study was conducted to finalise these and evaluate inter-observer variability delineated OAR by expert observers.The DNOG were formed participants from all centres that treat brain tumours with radiotherapy. In a two-day workshop, discussed finalised pilot study. Following this, ten contoured following OARs T1-weighted...
The clinical target volume (CTV) in radiotherapy is routinely based on gadolinium contrast enhanced T1 weighted (T1w + Gd) and T2 fluid attenuated inversion recovery (T2w FLAIR) magnetic resonance imaging (MRI) sequences which have been shown to over- or underestimate the microscopic tumor cell spread. Gliomas favor spread along white matter fiber tracts. Tumor growth models incorporating MRI diffusion tensors (DTI) allow account more consistently for glioma growth. aim of study was...
The fifth edition WHO classification of Tumors the Central nervous system (WHO-CNS5) integrated new molecular parameters to refine CNS tumor classification. This study aimed reclassify a retrospective cohort adult glioma patients according WHO-CNS5, and assess if overall survival (OS) correlated with revised diagnosis. Further, diagnostic impact methylation profiling (MP) was evaluated. Adult gliomas diagnosed 2016 WHO-CNS (n = 226) were evaluated WHO-CNS5 criteria. All had NGS performed. 29...
To investigate the direct relationship between tumour hypoxia and lactate dehydrogenase (Ldh) levels in serum two different pre-clinical murine models.Experiments were performed CDF1 or C3H/ Km mice implanted with a C3H mammary carcinoma SCCVII squamous cell carcinoma, respectively. Low oxygen breathing for 1-72 h was used to increase hypoxia. Ldh activity measured cytosole colorimetric method. Tumour Ldha mRNA assessed RT-PCR. RESULTS; The non-tumour bearing C3H/km 10.592 U/ml 1292 U/ml,...
Stereotactic radiosurgery (SRS) has proven an effective tool for the treatment of brain tumors, arteriovenous malformation, and functional conditions. However, radiation-induced therapeutic effect in viable cells SRS is also suggested. Evaluation proposed modulatory irradiation on neuronal activity without causing cellular death requires knowledge radiation dose tolerance at very small tissue volume. Therefore, we aimed to establish a porcine model study effects ultra-high radiosurgical...
Aims We aimed to reclassify a population‐based cohort of 529 adult glioma patients evaluate the prognostic impact 2016 World Health Organization (WHO) central nervous system tumour classification. Moreover, we evaluated feasibility gene panel next‐generation sequencing (NGS) in daily diagnostics 225 prospective patients. Methods The retrospective was reclassified according WHO criteria by immunohistochemistry for IDH‐R132H, fluorescence situ hybridization 1p/19q‐codeletion and NGS. All...
Modulation of pathological neural circuit activity in the brain with a minimum complications is an area intense interest.The goal study was to alter neurons' physiological states without apparent damage cellular integrity using stereotactic radiosurgery (SRS).We treated 7.5 mm-diameter target on visual cortex Göttingen minipigs doses 40, 60, 80, and 100 Gy. Six months post-irradiation, pigs were implanted 9 mm-wide, eight-shank multi-electrode probe, which spanned radiation focus as well...
Background. Stereotactic radiation therapy (SRT) of brain metastases is used with good effect around the world, but no consensus exists regarding which prognostic factors that are related to favourable or unfavourable prognosis after treatment. A better definition these will ensure a more precise application treatment.Material and methods. consecutive cohort 198 patients treated for SRT without concurrent whole-brain at our department from 2001 2012 was retrospectively analysed.Results....
Patients with lower-grade gliomas are long-term survivors after radiotherapy and may benefit from the reduced dose to normal tissue achievable proton therapy. Here, we aimed quantify differences in uninvolved brain contralateral hippocampus compare risk of radiation-induced secondary cancer for photon plans glioma patients.Twenty-three patients were included this in-silico planning comparative study had calculated (50.4 Gy(RBE = 1.1), 28 Fx) applying similar constraints target organs at...
Abstract Background This Danish cohort study aims to (1) compare patterns of care (POC) and survival patients with multifocal glioblastoma (mGBM) those unifocal (uGBM), (2) explore the association patient-related factors treatment assignment prognosis, respectively, in subgroup mGBM patients. Methods Data on all adults newly diagnosed, pathology-confirmed GBM between 2015 2019 were extracted from Neuro-Oncology Registry. To POC uGBM, we applied multivariable logistic Cox regression analysis,...