A5072796448- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Medical Imaging Techniques and Applications
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Atomic and Subatomic Physics Research
- Cardiac electrophysiology and arrhythmias
- Radiation Effects in Electronics
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Cardiac tumors and thrombi
- Chemotherapy-induced cardiotoxicity and mitigation
- Nuclear Physics and Applications
National Center for Oncological Hadrontherapy
2015-2025
Ospedale SS. Annunziata
2019
Ege University
2019
Ankara Yıldırım Beyazıt University
2019
Kyoto University
2016
Velindre Cancer Centre
2015
European Institute of Oncology
2006-2011
University of California, San Francisco
2006-2008
Abstract Background A multidisciplinary and multi-institutional working group applied the Failure Mode Effects Analysis (FMEA) approach to actively scanned proton beam radiotherapy process implemented at CNAO (Centro Nazionale di Adroterapia Oncologica), aiming preventing accidental exposures patient. Methods FMEA was treatment planning stage consisted of three steps: i) identification involved sub-processes; ii) ranking potential failure modes, together with their causes effects, using risk...
The aim of this study is to evaluate results in terms local control (LC), overall survival (OS), and toxicity profile better identify factors influencing clinical outcome skull base chordoma treated with proton therapy (PT) carbon ion radiotherapy (CIRT).We prospectively collected analyzed data 135 patients between November 2011 December 2018. Total prescription dose the PT group (70 patients) CIRT (65 was 74 Gy relative biological effectiveness (RBE) delivered 37 fractions 70.4 Gy(RBE) 16...
Abstract Background Pancreatic adenocarcinoma is a high-mortality neoplasm with documented 5-years-overall survival around 5%. In the last decades, real breakthrough in treatment of disease has not been achieved. Here we propose prospective, phase II, multicentre, single-arm study aiming to assess efficacy and feasibility therapeutic protocol combining chemotherapy, carbon ion therapy surgery for resectable borderline pancreatic adenocarcinoma. Method The purpose this trial (PIOPPO Protocol)...
In particle therapy, the uncertainty of delivered range during patient irradiation limits optimization treatment planning. Therefore, an in vivo verification device is required, not only to improve plan robustness, but also detect significant interfractional morphological changes itself. this article, effective and robust analysis regions with a discrepancy proposed. This study relies on by means in-beam Positron Emission Tomography (PET) was carried out INSIDE system installed at National...
ICONIC is a multicenter, open-label, nonrandomized phase II clinical trial aiming to assess the feasibility and activity of addition carbon ion radiotherapy immune checkpoint inhibitors in cancer patients who have obtained disease stability with pembrolizumab administered as per standard-of-care. The primary end point objective response rate, secondary points are safety, survival control rate. Translational research an exploratory aim. planned sample size 27 patients. study combination will...
The generation of synthetic CT for carbon ion radiotherapy (CIRT) applications is challenging, since high accuracy required in treatment planning and delivery, especially an anatomical site as complex the abdomen. Thirty-nine abdominal MRI-CT volume pairs were collected a three-channel cGAN (accounting air, bones, soft tissues) was used to generate sCTs. network tested on five held-out MRI volumes two scenarios: (i) CT-based segmentation channels, assess quality sCTs (ii) manual...
Introduction: Preserving the endocrine and reproductive function in young female cancer patients undergoing pelvic radiation is a significant challenge. While photon beam radiation's adverse effects on uterus ovaries are well established, impact of carbon ion radiotherapy women's largely unexplored. Strategies such as oocyte cryopreservation ovarian transposition commonly recommended for safeguarding future fertility. Methods: This study presents pioneering case successful pregnancy after...
In patients with recurrent ventricular tachycardia (VT), STereotactic Arrhythmia Radioablation (STAR) shows promising results. The STOPSTORM.eu consortium was established to investigate and harmonise STAR treatment in Europe. primary goals of this benchmark study were standardise contouring organs at risk (OAR) for STAR, including detailed substructures the heart, accredit each participating centre.Centres within asked delineate 31 OAR three cases. Delineation reviewed by expert panel after...
To identify suitable combination strategies for treatment planning and beam delivery in scanned carbon ion therapy of moving tumors.
Approach: Carbon plans five abdominal tumors were optimized on 4DCT data using the following approaches: 4DITV across all phases within a gating window, single phase uniform dose (SPUD), an innovative 4D tracking ITV strategy. Delivered single-fraction doses calculated time-resolved virtual CT images reconstructed from 2D cine-MRI series, Deformable Image...
Objective: To compare radiation-induced toxicity and dosimetry parameters in patients with locally advanced nasopharyngeal cancer (LANPC) treated a mixed-beam (MB) approach (IMRT followed by proton therapy boost) an historic cohort of full course IMRT-only.Material methods: Twenty-seven LANPC the MB were compared to similar 17 IMRT-only. The consisted first phase IMRT up 54–60 Gy second delivered boost 70–74 (RBE). total dose for IMRT-only was 69.96 Gy. Induction chemotherapy administrated...
Abstract The high dose conformity and healthy tissue sparing achievable in Particle Therapy when using C ions calls for safety factors treatment planning, to prevent the tumor under-dosage related possible occurrence of inter-fractional morphological changes during a treatment. This limitation could be overcome by range monitor, still missing clinical routine, capable providing on-line feedback. Dose Profiler (DP) is detector developed within INnovative Solution In-beam Dosimetry...
Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET)...
Some cancers such as sarcomas (bone and soft tissue sarcomas) adenoid cystic carcinomas are considered radioresistant to low linear energy transfer radiation (including photons protons) may therefore beneficiate from a carbon ion therapy. Despite encouraging results obtained in phase I/II trials compared historical data with photons, the spread of ions has been limited mainly because absence randomized medical data. The French health authorities stressed importance having for therapy.The...
Goal:In-beam Positron Emission Tomography (PET) is a technique for in-vivo non-invasive treatment monitoring proton therapy. To detect anatomical changes in patients with PET, various analysis methods exist, but their clinical interpretation problematic. The goal of this work to investigate whether the gamma-index analysis, widely used dose comparisons, an appropriate tool comparing in-beam PET distributions. Focusing on head-and-neck patient, we map and passing rate are sensitive...