A5033692691- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Angiogenesis and VEGF in Cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 and healthcare impacts
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Nausea and vomiting management
- Lung Cancer Research Studies
- Glioma Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
Policlinico San Matteo Fondazione
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
University of Pavia
2000-2023
Foundation Center
2021
Hudson Institute
2020
John Wiley & Sons (United States)
2020
Ospedale di Livorno
2009
University of Pisa
2009
University Hospital Foundation
2002
Associazione Italiana Di Oncologia Medica
1998-2001
Abstract In recent years, whey proteins (WP) have attracted increasing attention in health and disease for their bioactive functions. The aim of this study was to evaluate the benefit WP isolate (WPI) supplementation addition nutritional counseling malnourished advanced cancer patients undergoing chemotherapy (CT). a single‐center, randomized, pragmatic, parallel‐group controlled trial ( ClinicalTrials.gov : NCT02065726), 166 with mixed tumor entities candidate or CT were randomly assigned...
We conducted a randomized trial to evaluate whether melphalan-prednisone (MPH-P) treatment administered just after diagnosis improves survival of stage I multiple myeloma (MM). Between January 1987 and March 1993, 145 consecutive previously untreated patients with MM were between MPH-P (administered for 4 days every 6 weeks) only at disease progression. Survival was not influenced by either or progression (64 vs 71 months respectively). Comparing the first second group odds ratio death is...
Dendritic cells (DC) are central to the development of immune system responses. In a cohort 54 patients affected by colorectal cancer, we prospectively investigated number peripheral blood (PB) DC type 1 (DC1) and 2 (DC2) correlated their counts functionality stage disease vascular endothelial growth factor (VEGF) levels.At diagnosis, compared with healthy controls, presented reduced PBDC1 PBDC2 numbers (p < 0.001). Moreover, in cancer patients, PBDC showed low levels DC-associated antigens...
Environmental factors may play a role in colon cancer. In this view, several studies investigated tumor samples for the presence of various viral DNA with conflicting results.We undertook systematic analysis 44 consecutive, prospectively collected primary by real time and qualitative PCR viruses known or potential oncogenic humans, including polyomavirus (JCV, BKV, Merkel cell polyomavirus), HPV, HTLV, HHV-8 EBV. Negative controls consisted surgical resection margins. No evidence genomic...
Abstract Background Pancreatic adenocarcinoma is a high-mortality neoplasm with documented 5-years-overall survival around 5%. In the last decades, real breakthrough in treatment of disease has not been achieved. Here we propose prospective, phase II, multicentre, single-arm study aiming to assess efficacy and feasibility therapeutic protocol combining chemotherapy, carbon ion therapy surgery for resectable borderline pancreatic adenocarcinoma. Method The purpose this trial (PIOPPO Protocol)...
The overall risk of some cancers is increased in patients receiving regular dialysis treatment due to chronic oxidative stress, a weakened immune system and enhanced genomic damage. These could benefit from the same antineoplastic delivered with normal renal function, but better risk/benefit ratio be achieved by establishing specific guidelines. Key considerations are which chemotherapeutic agent use, adjustment dosages timing relation administration chemotherapy.We have reviewed available...
Sacral chordoma (SC) is a neoplasm arising from residual notochordal cells degeneration. SC difficult to manage mainly because of anatomic location and tendency extensive spread. Carbon ion radiotherapy (CIRT) highly precise selectively deliver high biological effective dose the tumor target sparing anatomical structure on its path even if when contiguous intestine, surgical spacer might be an advantageous tool create distance around volume allowing radical curative delivery with safe...
Treatment of advanced metastatic colorectal cancer (mCRC) patients is associated with a poor prognosis and significant morbidity. Moreover, targeted therapies such as anti-epidermal growth factor receptor (EGFR) have no effect in tumors harboring mutation the RAS gene. The failure conventional treatment to improve outcomes mCRC has prompted development adoptive immunotherapy approaches including natural killer (NK)-based therapies. In this study, after confirmation that patients’ NK cells...
Docetaxel associated with oxaliplatin and 5-fluorouracil (FLOT) has been reported as the best perioperative treatment for gastric cancer. However, there is still some debate about most appropriate number timing of chemotherapy cycles. In this randomized multicenter phase II study, patients resectable cancer were staged through laparoscopy peritoneal lavage cytology, randomly assigned (1:1) to either four cycles neoadjuvant (arm A) or two preoperative + postoperative docetaxel, oxaliplatin,...
The COVID-19 outbreak has drastically changed practices inside hospitals, which include oncology routines. In oncology, malnutrition was and certainly still is a frequent problem associated with an increase in treatment-related toxicity, reduced response to cancer treatment, impaired quality of life, worse overall prognosis. Even this situation healthcare crisis, nutritional support care essential element. During the current pandemic, there concrete high risk see dramatic worsening patients'...