A5057843015- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Palliative Care and End-of-Life Issues
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Monoclonal and Polyclonal Antibodies Research
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2015-2024
Azienda Ospedaliera Universitaria Senese
2024
University of Siena
2024
Royal Marsden Hospital
2024
University College London Hospitals NHS Foundation Trust
2016
University College London
2016
Asahikawa Medical University
2016
Ospedale "Santa Maria delle Croci" di Ravenna
2003-2004
Istituto Oncologico Romagnolo
2003
Despite the search for new therapeutic strategies gastric cancer (GC), there is much evidence of progression due to resistance chemotherapy. Multidrug (MDR) ability cells survive after exposure chemotherapeutic agents. The involvement miRNAs in development MDR has been well described but able modulate sensitivity chemotherapy by regulating hypoxia signaling pathways have not yet fully addressed GC. Our aim was analyze miR-20b, miR-27a and miR-181a expression with respect...
There is evidence of a different response to treatment with regard the primary tumor localization (right-sided or left-sided) in patients metastatic colorectal cancer (mCRC). We analyzed outcomes and biomolecular characteristics relation 122 370 enrolled onto phase III prospective multicenter “Italian Trial Advanced Colorectal Cancer (ITACa)”, randomized receive first-line chemotherapy (CT) CT plus bevacizumab (CT + B). RAS BRAF mutations; baseline expression levels circulating vascular...
Validated predictors of sensitivity or resistance to Bevacizumab (Bev) are not available, and Inflammatory Indexes (IIs) has been reported be useful prognostic factors in various malignant solid tumours, including metastatic colorectal cancer (mCRC).To explore the value IIs mCRC patients treated with first-line chemotherapy plus Bev.One hundred eighty-two diagnosed first line Bev were considered for this prospective non-pharmacological study. Neutrophil, lymphocyte, platelet, aspartate...
We created a new index (Multi Inflammatory Index, MII) composed of an inflammatory [neutrophil-to lymphocyte-ratio (NLR): MII-1; platelet-to-lymphocyte ratio (PLR): MII-2; or systemic immune-inflammation (SII): MII-3] and C-reactive protein (CRP). Our aim was to evaluate the prognostic and/or predictive capacity MII in randomized ITACa (Italian Trial Advanced Colorectal Cancer) study on patients with metastatic colorectal cancer undergoing first-line chemotherapy.Between November 2007 March...
CDH1 gene, encoding E-cadherin, is a tumor suppressor gene frequently altered in gastric cancers (GCs) of both diffuse (DGC) and intestinal (IGC) histotypes, albeit through different mechanisms. The study aimed to characterize expression sporadic IGC investigate whether microRNAs (miRs) are involved its transcriptional control. We evaluated by quantitative real-time PCR (RT-qPCR) 33 patients found significant downregulation tissues compared normal counterparts (p-value = 0.025). Moreover, 14...
We analyzed the clinical relevance of HER-2 expression, widely investigated in breast cancer but with contradictory results, largest case series node-negative patients to date.The pure prognostic value expression was 529 treated locoregional therapy alone until early relapse. Proliferative activity evaluated as [3H]thymidine labeling index and by immunohistochemistry. All biologic determinations were conducted within context an intra- interlaboratory National Quality Control Program.HER-2...
Background: Lung cancer is a complex disease with many subtypes. However, histochemical characteristics, and genetic mutation determinations are contributing to better define therapeutic targets new drugs. Although this guarantees patients the possibility of obtaining tailored treatment, it makes more difficult for clinicians patient management who have most suitable strategy deal treatment-related adverse events (TRAEs). It has been seen that administration tyrosine kinase inhibitor (TKI)...
Bordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection humans. We present rare case B. pneumonia patient with lung cancer. A 52-year-old white male non small cell cancer developed fever during treatment nivolumab. persistent productive cough and deterioration his clinical condition led to hospitalization for evaluation. Bronchoscopy was performed diagnosis made. The successfully managed by antiobiotic therapy....
Docetaxel associated with oxaliplatin and 5-fluorouracil (FLOT) has been reported as the best perioperative treatment for gastric cancer. However, there is still some debate about most appropriate number timing of chemotherapy cycles. In this randomized multicenter phase II study, patients resectable cancer were staged through laparoscopy peritoneal lavage cytology, randomly assigned (1:1) to either four cycles neoadjuvant (arm A) or two preoperative + postoperative docetaxel, oxaliplatin,...
Cellular resistance in advanced gastric cancer (GC) might be related to function of multidrug (MDR) proteins. The adaptor protein NHERF1 (Na+/H+ exchanger regulatory factor) is an important player progression for a number solid malignancies, even if its role develop drug remains uncertain. Herein, we aimed analyze the potential association between expression and P-gp, sorcin HIF-1α MDR-related proteins GC patients treated with epirubicin/oxaliplatin/capecitabine (EOX) chemotherapy regimen,...
BACKGROUNDAeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality patients with impaired hepatobiliary function.Asia has the highest incidence of infection from Aeromonas, whereas cases west rare. CASE SUMMARYWe report case a 64-year-old woman advanced pancreatic cancer jaundice who manifested fever, abdominal pain, severe thrombocytopenia, anemia kidney failure following insertion percutaneous transhepatic drainage.Blood culture results revealed presence...
We aimed to investigate the prognostic role of baseline and longitudinal levels neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic colorectal cancer (mCRC) treated chemotherapy + bevacizumab (CT B) or only. Additionally, we investigated whether treatment outcomes were mediated by biomarker.
Takotsubo syndrome (TTS) is an uncommon cardiovascular condition also known as stress-induced cardiomyopathy or broken heart disease. The syndrome, characterized by acute non-coronary segmental ventricular dysfunction, commonly occurs a reaction to severe emotional physical stress and can cause significant problems. Several classes of chemotherapeutic agents that are be cardiotoxic have been shown associated with TTS in cancer patients. Describing case from chemotherapy and/or monoclonal...
Introduction:We describe a case of acute hiatal hernia during chemotherapy, in female patient previously treated with gastrectomy.Case presentation: After gastric resection, the underwent developing important emetic symptoms.A radiograph abdomen was performed because epigastrial pain and it showed marked left diaphragm elevation.A CT scan carried out 24 hours later identified an occlusion herniation hemi thorax.Subsequent surgical investigation resulted diagnosis volvulus.Conclusions: This...
We present the first documented case of hemangioblastoma located in left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa sigmoid Endoscopic ultrasound showed an isoechoic lesion originating from third layer intestinal wall; underlying layers were normal. features not suggestive either or malignant stromal tumor. Left hemicolectomy was subsequently performed due to...
Aims and background Few studies show what happens outside of randomized clinical trials. The purpose the study was to describe management metastatic gastric cancer patients resident in Forlì area from 2000 2009. Methods design A total 270 at diagnosis or relapse were considered. Data medical records analysed, survival probabilities calculated using Kaplan-Meier method. Results 115 received best supportive care, 155 least one line chemotherapy, 71 (45.8%) underwent second-line therapy, 49...
Background and aims: Perioperative treatment is currently the gold standard approach in Europe for locally advanced gastric cancer (GC). Unfortunately, phenomenon of patients dropping out has been frequently observed. The primary aims this study were to verify if routine blood parameters, inflammatory response markers, sarcopenia, depletion adipose tissues associated with compliance neoadjuvant/perioperative chemotherapy. Methods design: Blood samples considered before first second cycles...
Therapeutic management of locally advanced gastric cancer (LAGC) combines surgery with neo-adjuvant (NACT) and adjuvant chemotherapy (ACT). miRNAs have emerged as promising candidates for treatment efficacy prediction, hence, the present study aims at defining therapy response-specific profiles circulating miRNAin LAGC. A prospective cohort 26 LAGC patients scheduled NACT, ACT was considered. Peripheral blood samples were collected prior to (preNACT) after NACT (postNACT) well tumor surgical...