A5105788696- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiation Effects in Electronics
- Effects of Radiation Exposure
- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Bone Tumor Diagnosis and Treatments
- Particle Detector Development and Performance
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Nuclear reactor physics and engineering
- DNA Repair Mechanisms
- Radiation Shielding Materials Analysis
- Anesthesia and Neurotoxicity Research
- Ocular Oncology and Treatments
- Graphite, nuclear technology, radiation studies
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
National Center for Tumor Diseases
2017-2025
Heidelberger Institut für Radioonkologie
2016-2025
National Center for Oncological Hadrontherapy
2016-2025
Heidelberg University
2017-2025
Deutschen Konsortium für Translationale Krebsforschung
2019-2025
University Hospital Heidelberg
2017-2025
German Cancer Research Center
2019-2025
Hamburg Institute for Therapy Research
2020
Zero to Three
2020
GSI Helmholtz Centre for Heavy Ion Research
2019
We report on the development of open-source cross-platform radiation treatment planning toolkit matRad and its comparison against validated systems. The enables three-dimensional intensity-modulated therapy for photons, scanned protons carbon ions.matRad is entirely written in Matlab freely available online. It re-implements well-established algorithms employing a modular sequential software design to model entire workflow. comprises core functionalities import DICOM data, calculate optimize...
onte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability a MC code for application demands accurate reliable physical models capable handling all components expected field. This becomes extremely important correctly performing not only but also biologically-based dose calculations, especially cases where ions heavier than protons involved. In addition, prediction...
In carbon ion radiotherapy there is an urgent clinical need to develop objective tools for the conversion of relative biological effectiveness (RBE)-weighted doses based on different models. this work we introduce a clinically oriented method compare NIRS-based and LEM-based GyE systems, minimizing differences in physical dose distributions between treatment plans. Carbon plans were optimized target volumes cubic spherical shapes, RBE-weighted prescription levels ranging from 3.6 4.4 GyE....
In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, experiments have evidenced RBE dependencies on dose level, linear energy transfer (LET) and tissue type. This work compares the predictions three main radio-biological models proposed in literature by Carabe-Fernandez, Wedenberg, Scholz coworkers. Using chosen models, spread-out Bragg peak (SOBP) as well two exemplary clinical cases (single field fields) for cranial irradiation,...
Hypoxia-induced radioresistance constitutes a major obstacle for curative treatment of cancer. The aim this study was to investigate effects photon and carbon ion irradiation in combination with inhibitors DNA-Damage Response (DDR) on tumor cell radiosensitivity under hypoxic conditions. Human non-small lung cancer (NSCLC) models, A549 H1437, were irradiated dose series ions hypoxia (1% O2) vs. normoxic conditions (21% O2). Clonogenic survival studied after dual combinations radiotherapy...
Helium ions offer intermediate physical and biological properties to the clinically used protons carbon ions. This work presents commissioning of first clinical treatment planning system (TPS) for helium ion therapy with active beam delivery prepare patients' at Heidelberg Ion-Beam Therapy Center (HIT).Through collaboration between RaySearch Laboratories HIT, absorbed relative effectiveness (RBE)-weighted calculation methods were integrated raster-scanned in TPS RayStation. At a modified...
The growing number of particle therapy facilities worldwide landmarks a novel era precision oncology. Implementation robust biophysical readouts is urgently needed to assess the efficacy different radiation qualities. This first report on evaluation Monte Carlo simulated predictive models prescribed dose for four qualities i.e., proton, helium-, carbon- or oxygen ions using raster-scanning technology and clinical settings at HIT. A high level agreement was found between in silico...
Radiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources requires estimation amount energy emitted by deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables specific absorbed fractions (SAFs) or S values based dosimetric models. The aim OpenDose collaboration is to generate make freely available a range data tools. <b>Methods:</b> brings together expertise from 18...
The optimal treatment strategy for low-grade glioma (LGG) is still a matter of controversy. Considering that the prognosis typically favorable, prevention late sequelae particular importance. Proton beam therapy (PRT) has potential to further reduce burden related side effects. We set out evaluate clinical outcome proton irradiation with focus on morphologic features magnetic resonance imaging (MRI).We assessed prospectively 110 patients who received radiotherapy protons histologically...
PurposeTo investigate brain tissue response to ultra-high dose rate (uHDR, FLASH) and standard (SDR) proton irradiations in the Bragg peak region.Methods MaterialsActive scanning uHDR delivery was established for beams investigation of effects between clinical SDR at ∼10 Gy region (dose-averaged linear energy transfer [LETD] ranging from 4.5 10.2 keV µm-1 ). Radiation- induced injury neuronal assessed by studying DNA double strand break repair kinetics surrogated nuclear γH2AX staining...
Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative proton for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain ocular meningiomas with protons ions, using first time dedicated Monte Carlo (MC) based planning engine (MCTP) thoroughly validated both in terms models. Starting from clinical plans four patients undergoing therapy fixed relative effectiveness (RBE) 1.1 fraction dose...
Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-precision cancer therapy. To identify patients most benefiting from this technologically demanding therapy, fast assessment comparative treatment plans utilizing different ion species is urgently needed. Moreover, to overcome uncertainties actual in-vivo physical dose distribution biological effects elicited by radiation qualities, development reliable high-throughput algorithm required. end, we engineered...
PurposeTo develop and validate combined ion-beam with constant relative biological effectiveness (RBE) (CICR) particle therapy in single field arrangements for improved treatment efficacy, robustness, normal tissue sparing.Methods MaterialsThe PRECISE (PaRticle thErapy using Combined Ion optimization StratEgies) planning system was developed to investigate clinical viability of CICR treatments. Single-field uniform dose (SFUD) a ion (proton [p], helium [He], or carbon [C]) (C-p C-He)...
While Monte Carlo (MC) codes are considered as the gold standard for dosimetric calculations, availability of user friendly MC suited particle therapy is limited. Based on FLUKA code and its graphical interface (GUI) Flair, we developed an easy-to-use tool which enables simple reliable simulations therapy. In this paper provide overview functionalities with presented clinical, proton carbon ion examples demonstrate reliability usability in clinical environment show flexibility research...
Helium (
PurposeTo evaluate the clinical potential of spot-scanning hadron arc (SHArc) therapy with a heavy-ion gantry.Methods and MaterialsA series in silico studies was conducted via treatment plan optimization FRoG RayStation TPS to compare SHArc against reference plans using conventional techniques single, parallel-opposed, 3-field configurations for 3 particle beams (protons [p], helium [4He], carbon [12C] ions). Tests were performed on water-equivalent cylindrical phantoms simple targets...
Proton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks reduced lateral scattering. Consequently, the potential clinical benefit of both techniques was explored. An explorative treatment planning study involving ten patients, previously treated with VMAT (Volumetric Modulated Arc Therapy) 50 Gy in 25 fractions locally advanced, node-positive cancer, carried out using proton...
Background: For tumours near organs at risk, there is concern about unintended increase in biological dose from elevated linear energy transfer (LET) the distal end of treatment fields. The objective this study was therefore to investigate how different paediatric posterior fossa tumour locations impact LET and brainstem during intensity-modulated proton therapy (IMPT).Material methods: Multiple IMPT plans were generated for four simulated relative a five-year-old male patient. A prescribed...